In zebrafish, injection of low doses of both Tuba and Cdc42 antisense morpholinos, which had no effect when administered separately, led to severe phenotypes similar to those seen following knockdown of other
ciliary proteins.
Lipschutz and others previously showed that the exocyst, a protein targeting complex, plays a crucial role in receiving these «zip - coded packages» containing
ciliary proteins.
Caenorhabditis elegans
ciliary protein NPHP - 8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation.
Not exact matches
The Penn researchers found that the fungal toxins activate
protein kinase C (PKC), which decreases
ciliary beat frequency and thus decreases MCC.
Moreover, in another Japanese patient, they identified a homozygous frameshift (p.L206fs), absent in more than 2,500 chromosomes from ethnically matched controls, in the
ciliary gene NEK2, encoding a serine / threonine -
protein kinase.
Abbreviations: BrdU, 5 - bromo -2-deoxyuridine; CMZ,
ciliary marginal zone; EFTF, eye field transcription factor; ERG, electroretinogram; GABA, gamma - aminobutyric acid; LE, lateral endoderm; N, number of animals or eyes; PNP, posterior neural plate; RPE, retinal pigment epithelium; YFP, yellow fluorescent
protein
The
Ciliary G -
Protein - Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling.
The regulation and activatin of
ciliary neurotrophic factor signaling
proteins in adipocytes.
We now show that astrocytes generated from the same population of human fetal glial precursor cells, by exposure to either bone morphogenetic
protein (BMP) or
ciliary neurotrophic factor (CNTF), promote widely divergent outcomes with respect to repairing the injured adult spinal cord.
Defective
ciliary function therefore leads to defective destruction of key
proteins, which then causes problems in interpreting the Wnt signal.