Sentences with phrase «circadian clock components»

Not exact matches

«In order to do that, you have to understand the complexity of all the enzymes and regulatory components associated with the circadian clock of the plant.»

In the current paper, knowing that MYC, a transcription factor that binds the genome through sites that are identical to the binding sites of BMAL1, the team hypothesized that aberrant MYC expression perturbs the clock by deregulating components of the circadian network in cancer cells.

Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in Japan and University of Michigan in the United States knew that a key component was missing and sough to uncover it in mammals.

Mice lacking molecular - clock components (Per and Cry), or lacking Per genes in osteoblasts, display high bone mass, suggesting that bone remodeling may also be subject to circadian regulation.

We want to unravel why the same components of the circadian clock in an adult regulate one set of genes while in an aged adult they regulate another set.

By studying the stem cells in two types of tissue, namely skin, muscle, and in liver, in young (three months old) and aged (18 to 22 months old) mice every four hours, «we observed that the core components of the circadian clock had no changes in their rhythm with age».

Within this broad topic we are particularly interested in characterising (i) the molecular mechanism by which these photoreceptors mediate light - dependent entrainment of the circadian clock, (ii) the components mediating, in a light - quality - dependent fashion, nucleocytoplasmic partitioning of phytochromes and UVR8, (iii) how phosphorylation and sumoylation of these photorecepors and other signalling components modulate red / far - red and UVB - induced signalling, and (iv) to what extent intercellular and cell - autonomous events contribute to phytochrome and UVR8 regulated photomorphogenesis.

According to many studies, besides keeping you awake for longer, late - night caffeine consumption can damage core components of the cellular circadian clock and have negative health consequences, especially in the form of cardiovascular problems.