Sentences with phrase «circadian clock proteins»

These researchers gave the mice synthetic agonists to certain nuclear receptors that are involved in controlling expression of circadian clock proteins...

«Our structures of the complexes of the circadian clock proteins of cyanobacteria provided important mechanistic insights, but are static snapshots of a system that's continuously moving and changing hour by hour,» said LiWang.

«A big surprise for us was the extent to which internal motions of circadian clock proteins dictate... their function,» LiWang said.

«Essentially we discovered that the circadian clock protein REVERB plays an important role in the safe accumulation of body fat.

Not exact matches

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

However, very little is known about how the circadian clock regulates this critical part of gene expression to organize the day - night rhythm of protein expression, and if the formation of this looping changes over the day.

Biologically speaking, the circadian clock determines the synthesizing «rhythm» for a whole range of proteins that are involved in a multitude of biological processes that shift while we sleep or wake.

He discovered a second clock gene, called timeless, that encodes another protein, TIM, which is required for a normal circadian rhythm.

Young also discovered other circadian clockworks, including doubletime and its protein DBT, which set the clock's pace.

«We have now found the first protein ever identified that translates timing information from the body's circadian clock and uses it to regulate sleep.»

«Cancer overrides the circadian clock to survive: Misfolded proteins cause disruptions in circadian rhythm that contribute to tumor growth.»

Researchers made a solution of these proteins and adenosine triphosphate (ATP), food for the proteins, to create a circadian clock that functioned for weeks.

LiWang's group discovered that how the proteins move hour by hour is central to cyanobacteria's circadian clock function.

Cyanobacterial clock proteins aren't exactly the same as the clock proteins of animals or human clocks, but proteins serve as the cogs, gears and springs of all circadian clockworks and the overall function of the proteins is similar.

They show that CHRONO functions as a transcriptional repressor of the negative feedback loop in the mammalian clock: the protein CHRONO binds to the regulatory region of clock genes, with its repressor function oscillating in a circadian manner.

«The disruption of the circadian clock machinery seems to affect not only the rhythm of appetite regulation, but also the expression of the genes and proteins at their absolute level,» says Turek, whose team reports its findings online today in Science.

It doesn't prove that CRY proteins control the circadian clock, but «it lays the groundwork to ask that question,» he says.

But the researchers were surprised to find that the plants» circadian clock genes only made more proteins with the same regular rhythm.

Altering the function of the clock circadian regulator (CLOCK) and brain and muscle ARNT - like protein 1 (BMAL1), which keep cellular functions synchronized with day - night rhythms, could treat metabolic probclock circadian regulator (CLOCK) and brain and muscle ARNT - like protein 1 (BMAL1), which keep cellular functions synchronized with day - night rhythms, could treat metabolic probCLOCK) and brain and muscle ARNT - like protein 1 (BMAL1), which keep cellular functions synchronized with day - night rhythms, could treat metabolic problems.

I. Edery, J. E. Rutila, M. Rosbash, «Phase shifting of the circadian clock by induction of the Drosophila period protein,» Science 263, 5144 (14 January 1994)

Z. J. Huang, K. D. Curtin, M. Rosbash, «PER protein interactions and temperature compensation of a circadian clock in Drosophila,» Science 267, 5201 (24 February 1995)

The Physiology or Medicine Prize recognized work on how several genes work together to control the basic circadian clock, encoding proteins that build up during the night and are broken down during the day.

Jeffrey Hall and Michael Rosbash of Brandeis University in Waltham, Massachusetts, and Michael Young of The Rockefeller University in New York City share the prize equally for their work on how several genes work together to control the basic circadian clock, encoding proteins that build up during the night and are broken down during the day.

In an apparent ironic twist to this year's prize, the quarry claimed by countless hours of sleepless toil is itself fundamental to a good night's sleep: the molecular basis of circadian rhythms — those genes and proteins whose interactions underlie the ability of us living organisms to keep our internal body clocks entrained to a 24 - hour cycle.

Ribosomal biogenesis and the translation of proteins included within their processing, folding and degradation have shown to be activated during the night and controlled by the circadian clock in past studies (Jouffe et al., 2013; Panda et al., 2002).

But now, researchers at the Gladstone Institutes have discovered how one important protein falls under direct instructions from the body's circadian clock.

Two clock proteins, CLOCK (Circadian locomoter output cycles protein kaput) and BMAL1 (Brain and Muscle Arnt - like1) bind to each other to form a heterodimer complex, which then binds to a DNA sequence called E-box (CACGTG) located in the upper region of clock genes, Per (Period) and Cry (Cryptochrome), present in the geclock proteins, CLOCK (Circadian locomoter output cycles protein kaput) and BMAL1 (Brain and Muscle Arnt - like1) bind to each other to form a heterodimer complex, which then binds to a DNA sequence called E-box (CACGTG) located in the upper region of clock genes, Per (Period) and Cry (Cryptochrome), present in the geCLOCK (Circadian locomoter output cycles protein kaput) and BMAL1 (Brain and Muscle Arnt - like1) bind to each other to form a heterodimer complex, which then binds to a DNA sequence called E-box (CACGTG) located in the upper region of clock genes, Per (Period) and Cry (Cryptochrome), present in the geclock genes, Per (Period) and Cry (Cryptochrome), present in the genome.

Light sets the circadian rhythm by eliminating a key protein needed for the molecular mechanism of the body's clock, according to scientists in the March 22 issue of Science.

With age, and / or with a dysfunctional circadian clock, our blood vessels add more collagen, a structural protein that helps provide strength to blood vessels, bone and skin, and less elastin, an also pervasive protein in our bodies that enables flexibility.

«What I like about the circadian clocks and chemotaxis systems is the protein networks are tied intimately to the behavior of the organisms,» says Crane.

The connection appears to be between Bmal1, a transcription factor that senses light and drives our master circadian clock, and ADAM17, an enzyme that sets inflammation - producing proteins free from our cells to target and thicken our blood vessel walls.

Cyanobacteria possess one of the simplest known circadian clocks — the KaiABC system, a complex of proteins that undergoes a 24 - hour biochemical cycle, which triggers oscillations in gene expression and physiological activity.