Extended effects of evening meal carbohydrate - to - fat ratio on fasting and postprandial substrate metabolism
Circadian clocks optimally adapt to sunlight for reliable synchronization Sofer S, Eliraz A, et al..
In fact, sleep researcher Dr. Michael Breus explains that camping for one week (away from artificial light) resets
circadian clocks.
We study how various physiological and molecular processes including physical activity, fat metabolism,
circadian clocks, advanced glycation end products, calcification and intestinal permeability are influenced by nutrients to impact organismal health and survival.
Cyanobacteria possess one of the simplest known
circadian clocks — the KaiABC system, a complex of proteins that undergoes a 24 - hour biochemical cycle, which triggers oscillations in gene expression and physiological activity.
«What I like about
the circadian clocks and chemotaxis systems is the protein networks are tied intimately to the behavior of the organisms,» says Crane.
Researchers had previously theorized that the loss of transcription and encoding functions in older brains was due to deteriorating core
circadian clocks.
However, when they removed sugar for periods of time, simulating a period of «nighttime» starvation, the bacterial
circadian clocks would quickly reset.
As for what better knowledge of
circadian clocks could unlock in the distant future, Rust entertains a tantalizing possibility.
He utilizes Drosophila genetics, bioinformatic (RNA - Seq, ChIP - Seq), and molecular genetic approaches to identify transcriptional regulators of
circadian clocks and longevity.
He is familiar with
circadian clocks and especially jet lag as important performance factors that can affect performance.
«In 2015, we had reported the synthesis of a molecule with demonstrated period - shortening activities on mammalian
circadian clocks discovered through a collaboration between ITbM's chronobiologists, synthetic chemists and theoretical scientists,» says Yoshimura.
A possible link between
circadian clocks, regulation of glucose metabolism, and melatonin signaling in the pancreas was indicated by genetic studies (255).
«In order to completely relieve jet lag, it is necessary to adjust both the central and peripheral
circadian clocks.
Currently we know very little about how
our circadian clocks interact with viruses at the molecular level.
Intriguingly, recent studies have also found a link between
circadian clocks and metabolism.
«Important metabolic functions are also heavily influenced by
circadian clocks, which is why activities such as chronic night - shift work — which can cause a misalignment of this clock — increase one's risk for metabolic and autoimmune diseases such as obesity, Type 2 diabetes, cancer and multiple sclerosis,» said Dr. Akassoglou.
His lab, the largest at the Buck, has diverse projects underway, including: understanding the link between aging and nutrients, gut function, calcification,
circadian clocks and diabetic complications.
Early work in plants and insects had, in fact, established the existence of such
circadian clocks, but it wasn't until the mid-1980s that the researchers uncovered the inner molecular workings behind this basic process.
Circadian clocks regulate functions ranging from alertness and reaction time to body temperature and blood pressure.
Disruption of
circadian clocks has been associated with accelerated aging and is a risk factor for many age - related diseases including cancer and diabetes.
J. D. Plautz et al., «Independent photoreceptive
circadian clocks throughout Drosophila,» Science 278, 5343 (28 November 1997)
The role of
circadian clocks in modulating nutrient responses.
On a lark, Hirsh's team decided to examine how flies with mutated
circadian clocks handle their cocaine.
Now that issue has been put to rest: In last week's issue of Science (13 December, pp. 2211 and 2213), researchers showed that mice that lack melanopsin do not normally reset
their circadian clocks in response to light, suggesting that melanopsin is capturing and relaying the light signal.
The authors suggest that humans may have internal clocks that track the lunar cycle, much like
circadian clocks that sync up with the rise and fall of the sun.
All of this suggests that
circadian clocks can be cued by social roles and that the rhythms can be much more complicated than scientists thought, the team reports online today in the Proceedings of the Royal Society B. «People seem to think about daily activity patterns as something that's more or less fixed in a species,» Kempenaers says.
Researchers have identified a mutation in some people who suffer from delayed sleep phase disorder, which interferes with
their circadian clocks
«Studies strongly suggest a link between
circadian clocks, insulin resistance and diabetes development,» explains Charna Dibner, the co-director of the study.
TIMEKEEPERS Three Americans have won the Nobel Prize in physiology or medicine for discovering the gears of
circadian clocks and how they govern daily rhythms, such as sleep, metabolism and other body processes.
The constant light of the Arctic summer and constant darkness of the winter make it difficult to tune
circadian clocks to environmental cues.
Circadian clocks are usually «entrained» by the day - night cycle.
«What makes
circadian clocks tick?
«The results are profound, for a number of different reasons,» says Steven Kay, a geneticist at the Scripps Research Institute in La Jolla, California, who studies
circadian clocks in plants.
In other words, stressors that affect
our circadian clocks, such as blue - light exposure, can have much more serious consequences than originally thought.
It has been known to play a central role in
the circadian clocks of insects for some time.
«
Circadian clocks under the microscope.»
Circadian clocks regulate the behaviour of all living things.
Circadian clocks are found within microbes and bacteria, plants and insects, animals and humans.
Chronobiology is the discipline that examines these and other questions about
the circadian clocks of all living organisms from protozoans to humans.
For example, it could help in the mornings when we need to be at peak alertness or in cases of jet lag when we change time zones abruptly and
our circadian clocks get thrown off.
The internal body clocks, called
circadian clocks, regulate the daily «rhythms» of many bodily functions, from waking and sleeping to body temperature and hunger.
Kay says the study also «raises the possibility that many other bacteria maintain
circadian clocks.
Even microorganisms, which lack a nervous system, have daily cycles of activity and inactivity driven by internal body clocks known as
circadian clocks.
Scientists are still debating how and why
the circadian clocks that govern biological timekeeping evolved.
C. reinhardtii algae is illuminated with red (left) and violet (right) light, which resets
their circadian clocks via a novel pathway.
Circadian clocks, which reset about every 24 hours, are common in organisms living on Earth's surface.
TAKING ITS TIME
Circadian clocks in some animals tick - tock to a different beat, like this member of brood II, one of the 17 - year cicada species that emerged in 2013.
Circadian clocks choreograph a host of biological events: when to wake, when to sleep, when to emerge from a burrow; when to put out a spore, open...
Mammals, humans included, have
circadian clocks that work with the same logic and many of the same gears found in fruit flies, say Jennifer Loros and Jay Dunlap, geneticists at the Geisel School of Medicine at Dartmouth College.
«Bacteria engineered with synthetic
circadian clocks.»