Sentences with phrase «circadian gene»

In the initial report, mice harboring a mutation in the core circadian gene Clock (termed Clock mutant mice) were fed a high - fat (HF) diet and observed to develop obesity at a young age, as well as a variety of metabolic and endocrine abnormalities consistent with the metabolic syndrome (2).

Coactivator - Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude through REV - ERB Loading.

His research is focused on understanding how environmental factors, such as nutrients and light, influence circadian gene expression and the processes of aging.

The authors characterize a new circadian gene that they name Chrono.

«Financial stress is associated with migraine, if you have specific circadian gene variants.»

What we need to do now is to see if other circadian gene variants in association with different stress factors cause the same effect.

But when the UPR was chemically activated, Bmal1 stayed low during both light and dark phases, which caused a phase shift in the expression of circadian genes.

Scientists compared urination patterns, both volume and frequency, in normal mice and in mice genetically engineered without two circadian genes, Cryptochrome - 1 and Cryptochrome - 2, resulting in dysfunctional circadian rhythms.

At the end of 3 weeks, when the volunteers were waking up about 4 hours later than they used to, the activity of their hair follicle circadian genes had shifted too — but only by about two and a half 2 1/2 hours, the team reports online today in the Proceedings of the National Academy of Sciences.

Researchers also found that levels of cAMP and pCREB, possible upstream regulators of some circadian genes, were correlated with locomotor activity.

This image illustrates concepts in the press release titled «Infradian oscillation of circadian genes in a mouse model of bipolar disorder».

Circadian genes turned out to be also infradian genes, whose expressions go up and down with mood - change - like behaviors in these mice,» Miyakawa explains.

Our preliminary data demonstrates that DR enhances the amplitude of circadian genes and may inhibit the age - relate decline in loss of circadian homeostasis.

«The current results provide the evidence for a novel concept that some circadian genes and their regulatory machinery in the brain may be involved in the generation of infradian rhythm behavior,» Miyakawa explains.

Specifically, the regular oscillations of other circadian genes in the brain and the liver became disrupted, as well as genes known to regulate glucose and lipid metabolism.

Not exact matches

Saper and his colleagues have been studying the brain's suprachiasmatic nucleus, or SCN, which resets our daily circadian clock, and the genes that control wakefulness.

In 1997 Joseph Takaha - shi of the Howard Hughes Medical Institute at Northwestern University and his colleagues isolated a gene they called Clock that when mutated yielded mice with no discernible circadian rhythm.

Because different mutations in the same gene caused the three behaviors, we concluded that per is somehow actively involved both in producing circadian rhythm in flies and in setting the rhythm's pace.

Ueli Schibler of the University of Geneva showed in 1998 that the per genes of rat connective - tissue cells called fibroblasts are active according to a circadian cycle.

Exposure to bright light at night resets circadian rhythms by acutely changing the amount of some clock - gene products.

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

Up to 15 percent of people's genes are regulated by the day - night pattern of circadian rhythms, including those involved with metabolic pathways in the liver.

«Most interestingly, we found a similar dynamic, or circadian, looping when we studied a gene called Glycogen synthase 2,» says Felix Naef.

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

In recent years, clock researchers have uncovered some of the gears and springs that keep this circadian timepiece running, largely by identifying a handful of key genes in organisms from bread mold to mice.

CLOCK is an acronym for «Circadian Locomotor Output Cycles Kaput,» because it is a central regulator of gene expression related to the body's circadian rhythm of sleeping anCircadian Locomotor Output Cycles Kaput,» because it is a central regulator of gene expression related to the body's circadian rhythm of sleeping ancircadian rhythm of sleeping and waking.

However, very little is known about how the circadian clock regulates this critical part of gene expression to organize the day - night rhythm of protein expression, and if the formation of this looping changes over the day.

The researchers then inactivated a distal DNA enhancer element that contains instructions to transcribe Cryptochrome 1, which is a gene that produces a protein involved in maintaining the circadian rhythm itself.

He discovered a second clock gene, called timeless, that encodes another protein, TIM, which is required for a normal circadian rhythm.

Mutations of miR - 182 have been associated with a wide range of disorders, including insomnia and depression, and elevated expression appears to impact genes that regulate the body's circadian rhythm.

Since those discoveries, researchers have found that nearly every cell in the body contains a circadian clock, and almost every gene follows circadian rhythms in at least one type of cell.

Sancar's lab performed XR - seq on UV - exposed Arabidopsis over 24 - hour periods to discover that the efficiency of transcription - coupled repair also varies according to the «circadian» day / night cycle for 10 to 30 percent of Arabidopsis's genes.

The studied gene is involved in the circadian system, which has previously been shown to be implicated in mental disorders such as bipolar disorder, which intriguingly is comorbid with migraine.

According to a new study, one reason may be that the genes that set the body clock are intimately connected to our immune cells: Messing with the circadian rhythm leads to messed - up immune cells.

Genes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the ArGenes with mammoth - specific changes were most strongly linked to fat metabolism (including brown fat regulation), insulin signaling, skin and hair development (including genes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Argenes associated with lighter hair color), temperature sensation and circadian clock biology — all of which would have been important for adapting to the extreme cold and dramatic seasonal variations in day length in the Arctic.

With her HHMI money, she will explore the connections between the immune system and circadian clock genes, as well as the link between immune response and DNA repair genes.

Light signals from the eyes keep the internal circadian rhythm generated by clock genes coordinated with the environment.

The researchers found that MYC may affect circadian rhythm and metabolism by promiscuously binding to promoter regions in key genes for maintaining these daily cycles.

«Our findings suggest this is because part of the biological mechanism behind the damage is affected by a person's circadian clock and the underlying genes that control it.»

They show that CHRONO functions as a transcriptional repressor of the negative feedback loop in the mammalian clock: the protein CHRONO binds to the regulatory region of clock genes, with its repressor function oscillating in a circadian manner.

The system relies on several genes, but one in particular seems to be a primary driver of the circadian machinery.

«The Y6 gene is highly expressed in a part of the brain called the «hypothalamic suprachiasmatic nucleus», which is known to control the body's circadian rhythm and may also critically modulate metabolic processes in response to food.

«Clock genes» control our circadian rhythms, and the easiest place to extract evidence of their activity is from hair follicles, according to researchers at Japan's Yamaguchi University.

The expression of core clock genes is altered in mice lacking the Chrono gene, and the mice have longer circadian cycles.

«The disruption of the circadian clock machinery seems to affect not only the rhythm of appetite regulation, but also the expression of the genes and proteins at their absolute level,» says Turek, whose team reports its findings online today in Science.

In mice heterozygous for tau - lacZ targeted to the melanopsin gene locus, β - galactosidase — positive RGC axons projected to the SCN and other brain nuclei involved in circadian photoentrainment or the pupillary light reflex.

Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro Goriki, Toru Takumi and their colleagues from RIKEN and Hiroshima University in Japan and University of Michigan in the United States knew that a key component was missing and sough to uncover it in mammals.

Animals with gene mutations that significantly alter their circadian rhythms have shorter life spans, and circadian rhythm sleep disorders in humans can have profoundly negative effects, including increased risk for obesity, depression, cardiovascular disease and cancer.

But the researchers were surprised to find that the plants» circadian clock genes only made more proteins with the same regular rhythm.

Researchers have identified the first gene involved in the circadian clock of humans.