Recent research has also focused on circadian rhythms in adolescents as a function of puberty; the role of
circadian phase preference on daytime sleepiness patterns; and the influence of alcohol use and the history of parental alcohol use on sleep patterns and circadian rhythms of young people.
This procedure permitted participants to initially sleep at their habitual entrained
circadian phase.
Insufficient sleep delayed circadian melatonin phase and also led to an earlier
circadian phase of wake time.
Total sleep time,
circadian phase shift, and
circadian phase relationships did not differ by sex (all P > 0.37).
Specifically, participants may have eaten smaller breakfasts because they awakened at an earlier
circadian phase when the internal circadian clock was promoting sleep; i.e., wake time occurred during the biological night when melatonin levels were still high.
Lastly, we examined satiety and hunger hormones released by adipose tissue (leptin), stomach (ghrelin), and small intestine [peptide YY (PYY)-- PYY reduces food intake], feelings of hunger and physical exhaustion, light exposure, and
circadian phase.
Changes in
circadian phase and the circadian timing of awakening may have contributed to the altered eating patterns during insufficient sleep.
But a later study reported that body temperature can be off by as much as 5 hours from
circadian phase, so Wright and Czeisler tracked levels of the nighttime hormone melatonin, thought to be a more precise measure.
«You can see by eye, when the cell is wounded only 8 hours apart from each other, in a different
circadian phase, the [daytime] wounded ones take off, and the [nighttime] one drags,» O'Neill says.
Not exact matches
Turning from the micro to the macro world, biological organisms also exist through reiterating
phased processes, notably in the
circadian rhythms such as alternating waking and sleeping.
But when the UPR was chemically activated, Bmal1 stayed low during both light and dark
phases, which caused a
phase shift in the expression of
circadian genes.
Future modeling studies will try to determine if there is an optimal
phase for taking one drug or the other to improve the amplitude of
circadian rhythms.
The healthiest
circadian rhythms are the ones that are considered to be «high - amplitude» — where different and complementary processes occur in the body during distinct and regular daytime and nighttime
phases.
Chang: Recent studies have shown that short - wavelength [blue] light has a greater effect on
phase shifting the
circadian clock and on melatonin suppression.
Chang: We have known for quite awhile now that light is the most powerful cue for shifting the
phase or resetting the time of the
circadian clock.
Researchers have identified a mutation in some people who suffer from delayed sleep
phase disorder, which interferes with their
circadian clocks
Knight says some of the strongest evidence for a bacterial role in
circadian - linked diseases lies in the final
phase of the study, when the research team analyzed fecal samples from two people on a normal schedule and two more who had recently flown from the United States to Israel.
However, they display severely attenuated
phase resetting in response to brief pulses of monochromatic light, highlighting the critical role of melanopsin in
circadian photoentrainment in mammals.
These mice entrained to a light / dark cycle,
phase - shifted after a light pulse, and increased
circadian period when light intensity increased.
Behaviorally, the mutants had an intrinsic
circadian period about 1 hour longer than normal and exhibited high - amplitude
phase shifts in response to light pulses administered at
circadian time 17.
I. Edery, J. E. Rutila, M. Rosbash, «
Phase shifting of the
circadian clock by induction of the Drosophila period protein,» Science 263, 5144 (14 January 1994)
A carefully calibrated
circadian rhythm adapts our physiology to different
phases of the day.
Circadian melatonin phase and phase relationships to scheduled sleep and wake times were similar for BL and 9 - h conditions, whereas circadian melatonin onset phase significantly delayed by ∼ 1.5 h and the duration between wake time and circadian melatonin offset phase was significantly longer in the 5 - h condition
Circadian melatonin
phase and
phase relationships to scheduled sleep and wake times were similar for BL and 9 - h conditions, whereas
circadian melatonin onset phase significantly delayed by ∼ 1.5 h and the duration between wake time and circadian melatonin offset phase was significantly longer in the 5 - h condition
circadian melatonin onset
phase significantly delayed by ∼ 1.5 h and the duration between wake time and
circadian melatonin offset phase was significantly longer in the 5 - h condition
circadian melatonin offset
phase was significantly longer in the 5 - h condition (Fig. 1).
Short - wavelength [blue] light has a greater effect on
phase shifting the
circadian clock and on melatonin suppression.
Food intake during the normal activity
phase prevents obesity and
circadian desynchrony in a rat model of night work
Wyatt, J.K., Cajochen, C., et al. (2004) Low - dose repeated caffeine administration for
circadian -
phase - dependent performance degradation during extended wakefulness.