Sentences with phrase «circuit function in»

«Estrogen alters memory circuit function in women with gene variant: Hormone - gene interaction may underlie sex / individual differences in mental disorders.»

Not exact matches

There was a lot of obfuscation in Facebook's announcement on Tuesday, but the bottom line is that the social - networking behemoth has short - circuited the way that ad blockers function, by removing all the indicators that tell ad - blocking software what is an ad and what isn't.

You do seem to use a communication device, which I can only imagine you've craftily fashioned from hemp and sisal, with no chemicals in use in the circuit boards, wires, batteries, screen or any other part of the functioning device.

A key function of the «emotional» circuit is to regulate a parent's vigilance and awareness of the child's safety, making them chime in with their child's needs and make sure they're met.

For safety, the unit has an automatic shut - off function that turns off automatically when there is no water in the tank to avoid overheating and short circuit.

Then, using motor circuits, kids use electric functions in their dollhouses with windmills, blenders, pottery wheels, carousels, and elevators.

Dr. Saper's research has explored circuitry of the brain that controls basic functions such as wake - sleep cycles, feeding, and immune response, and how these circuits are disrupted in neurological disorders, such as Parkinson's disease, in sleep disorders such as narcolepsy and sleep apnea, and during aging.

We're funding researchers to investigate how drugs alter what genes are activated such that they modify the function of the cells, and how this, in turn, modifies the functions of brain circuits, and how that modifies behavior.

Gait disturbance in individuals with spinal cord injury is attributed to the interruption of neural pathways from brain to the spinal locomotor center, whereas neural circuits locate below and above the lesion maintain most of their functions.

The potential for mind - boosting drugs and technologies has increased stunningly over the past decade as neuroscientists have unlocked the secrets of neuronal circuits, neurotransmitters, and specific molecular events triggering brain functions in three interconnected cognitive domains — attention, memory, and creativity.

However, the circuit in the fly's mVG described in this work functions to regulate a developmental step in the insect's life, unlike a behavioural urge like hunger that the hypothalamus regulates in mammals.

«In actual fact, these mutants have everything in them to be able to pupate, but because this circuit is not functioning properly, they are unable to ignore the protein deficit,» she continueIn actual fact, these mutants have everything in them to be able to pupate, but because this circuit is not functioning properly, they are unable to ignore the protein deficit,» she continuein them to be able to pupate, but because this circuit is not functioning properly, they are unable to ignore the protein deficit,» she continues.

These findings could be a step in grasping how the brain circuit is shaped during this early stage development and how these neuronal circuits contribute to higher cognitive function in adulthood.

Astrocytes are star - shaped cells in our brain that surround brain neurons, and neural circuits, protecting them from injury and enabling them to function properly — in essence, one of their main roles is to «baby - sit» neurons.

A first step in this field is for researchers to demonstrate that single molecules can function as reproducible circuit elements such as transistors or diodes that can easily operate at room temperature.

Pass it on: Depressed patients may have problems with the function of a brain circuit thought to be involved in feelings of hate.

They then attached strips of gold to both ends of each nanotube, creating a transistor, and linked up to three such devices in various ways to make circuits that would execute simple logical functions: flipping a signal from off to on or vice versa, turning two off signals into an on, storing a unit of information or creating an oscillating signal.

We know that a number of structural changes also occur during this developmental period, and we now can attempt to link those changes to the changes in circuit function.

In animals, for example, distinct neural circuits control different functions, such as vocalization and vision.

Brain imaging studies have shown that stimulation over this region modulates the functioning of fronto - striatal circuits, leading to the release of dopamine, a key neurotransmitter in reward processing.

With the novel genetic access to hippocampal chandelier cells developed in the Taniguchi Lab at MPFI, neuroscientists can begin asking questions about the function of these cells within learning and memory circuits.

Thus, this study found that women who have recovered from anorexia nervosa show two related patterns of changes in brain circuit function that may contribute to their capacity to sustain their avoidance of food.

In order to modulate the functioning of fronto - striatal circuits, the researchers from the lab of Robert Zatorre used a non-invasive brain stimulation technique, transcranial magnetic stimulation (TMS), which uses magnetic pulses to either stimulate or inhibit selected parts of the brain.

«Importantly, we use mice as models of human beings in research, and so when looking for anti-obesity drugs, we need to fully understand the function of the NPY system in this animal model to understand how similar circuits in humans connect with the body clock.»

Our method is a first step toward developing a new mathematical toolkit to uncover the structure of neural circuits with unknown function in the brain.»

One disadvantage with these switch - like approaches is that they can mask more subtle functions of neuronal circuits in regulating behaviors.

When a new granule cell neuron is made in the dentate gyrus, it needs to get «wired in,» by forming synapses, or connections, in order to contribute to circuit function.

The gene - by - hormone interaction's effect on circuit function was found only with one of two versions of the gene that codes for BDNF (brain - derived neurotrophic factor), a chemical messenger operating in the circuit.

In the past, MRIs have been considered risky because of the fear a pacemaker or defibrillator device's generator circuits could be disrupted, or its metal leads could be pulled out of place by the magnetism, or the lead tips could become hot and scar surrounding tissues, interfering with pacing and defibrillating function.

Because the RNAi wasn't used to dampen FOXP2 activity until 23 days after the birds hatched, the new study shows that the gene has a role beyond embryonic development, says neurogeneticist Simon Fisher of the University of Oxford in the U.K. «The gene, at least in songbirds, may have important active functions in [neural] circuits,» he says.

Jon Storm - Mathisen, Professor of Anatomy at the University of Oslo, and chairman of the Kavli Neuroscience Prize Committee, said: «Major questions in modern brain science are how the complex neuronal circuits of the brain and spinal cord are assembled during development and how they function in the adult.

Much more work is required to determine whether electrical modulation of memory circuits could be used as a therapeutic strategy to enhance function in patients with memory disturbances.

In a pioneering series of anatomical studies carried out over the past three decades, Rakic has revealed how neurons in the developing cerebral cortex are generated and how they assemble themselves into highly ordered, distinctively layered, and densely interconnected circuits that direct higher order sensory and motor functionIn a pioneering series of anatomical studies carried out over the past three decades, Rakic has revealed how neurons in the developing cerebral cortex are generated and how they assemble themselves into highly ordered, distinctively layered, and densely interconnected circuits that direct higher order sensory and motor functionin the developing cerebral cortex are generated and how they assemble themselves into highly ordered, distinctively layered, and densely interconnected circuits that direct higher order sensory and motor functions.

Examples of funding areas include but are not limited to molecular genetic analysis of relevant neural circuit assembly and function; genetic and epigenetic research; animal models created by genetically altering neural circuits; and testing of new chemical entities that might be used in animal models as exploratory treatments.

We aim to identify molecular, circuit, and network mechanisms of cognitive dysfunction and to develop novel therapeutic approaches to restore brain functions in AD and related disorders.

How are these functions of neural circuits encoded in the genome?

This is something that is very difficult to predict, because, of course, if you insert a cell into the circuit, it should acquire very specific neuronal identity in order to exert then also specific functions.

At Weizmann, Dr. Spiegel will be establishing his own independent research group which will attempt to identify the molecular and cellular mechanisms through which experience alters the structure and function of neural circuits in the brain in behaviorally relevant ways and to understand how these processes, when they go awry, might give rise to psychiatric disorders.

The CCP is engaged in numerous multidisciplinary projects in other model systems (e.g. fly, zebrafish, yeast) that aim to determine how complex molecular circuits function and evolve in response to genetic and environmental changes, cellular differentiation, evolution and disease.

We could, for example, analyze how single neurons function in a cascade within the neuronal circuit,» Straw emphasizes the potential of his work.

He joined the Polleux lab in 2017 where he studies how the endoplasmic reticulum (ER) and mitochondria networks regulate spatiotemporal dynamics of dendritic calcium in the context of synaptic integration, plasticity, circuit function and behavior.

By combining cell physiology with pharmacology, behavioral analysis, and computer modeling, he has deciphered the existence of a central pattern generator for locomotion in the spinal cord, thereby linking circuit function to behavior.

With this tool, neuroscientists can use light to trigger or suppress neuronal firing and precisely manipulate animal behavior, allowing them to map circuits underlying normal brain functions and study their dysfunction in mood and movement disorders.

«Scientists had identified and diagrammed these circuits in the late 80s and early 1990s, but there had been no way to test their function in animal models,» explained Dr. Kreitzer.

In order to analyze the function of individual proteins in neuronal circuits or synaptic remodeling, researchers combine the Cre and FLP recombinases to control both knockout of a target gene and expression of a separate genIn order to analyze the function of individual proteins in neuronal circuits or synaptic remodeling, researchers combine the Cre and FLP recombinases to control both knockout of a target gene and expression of a separate genin neuronal circuits or synaptic remodeling, researchers combine the Cre and FLP recombinases to control both knockout of a target gene and expression of a separate gene.

A persistent challenge in unraveling mechanisms that regulate memory function is how to bridge the gap between inter-molecular dynamics of single proteins, activity of individual synapses and emerging properties of neuronal circuits.

Caroni's group focuses on the specific mechanisms that regulate plasticity in identified circuits as a function of experience, and the roles of this plasticity in learning and memory.

D melanogaster represents a useful experimental system for analyzing the functions of neuronal circuits the results from which can translate to neuronal function in other organisms, perhaps even including humans.

Finally, by using these methods to identify the important circuits, new drugs can be developed to home in on these specific circuits now that their function is known.

He used this phenomenon to generate the basic logic functions and other features required for computation, thereby creating the first computer circuit in which all components were of nanometer scale.