The brain takes its signals from the amount of circulating cortisol — not
circulating aldosterone — so high cortisol tends to lower the brain's ACTH production, which in turn decreases aldosterone secretion, leading to lower blood pressure.
Past research, Kopf said, shows the elevating
circulating aldosterone levels are associated with high blood pressure, blood clot formation, thickening of the heart muscle (called cardiac hypertrophy) and congestive heart failure.