«A high level of
circulating insulin could interfere with sex
hormone activity and boost
estrogen levels, both of which might increase the number of menstrual cycles and deplete egg supply faster, thus causing an earlier menopause.»
In a clinical study comparing oral
estrogen alone with oral E&T therapy, E&T therapy significantly increased
circulating levels of estradiol and free testosterone compared with baseline.13, 34 Circulating estradiol levels increased in a similar fashion to women assigned to estrogen - only therapy, while the increase in free testosterone and the reduction in luteinizing hormone and sex hormone — binding globulin levels were significantly greater among the E&T group compared with the estrogen - on
circulating levels of estradiol and free testosterone compared with baseline.13, 34
Circulating estradiol levels increased in a similar fashion to women assigned to estrogen - only therapy, while the increase in free testosterone and the reduction in luteinizing hormone and sex hormone — binding globulin levels were significantly greater among the E&T group compared with the estrogen - on
Circulating estradiol levels increased in a similar fashion to women assigned to
estrogen - only therapy, while the increase in free testosterone and the reduction in luteinizing
hormone and sex
hormone — binding globulin levels were significantly greater among the E&T group compared with the
estrogen - only group.34