LPR - induced weight loss in women was associated not only with significant reductions in fat mass and
circulating leptin concentrations but also with the relative abundance of bacteria of the Lachnospiraceae family in faeces.
These authors speculated that, as for other endocrine systems (33,34), the CNS might interpret an increase in leptin pulse amplitude as a signal calling for a decrease in appetite independently from any change in the integrated
circulating leptin concentration (32).
Our data directly address this hypothesis because we observed a decrease in leptin pulse amplitude between visit CRC1 and visit CRC2 (decreased peak minus nadir plasma leptin concentration and decreased AUC of the change in leptin) without a significant change in integrated
circulating leptin concentration (leptin AUC).
Not exact matches
Havel et al (32) reported that substitution of carbohydrate for dietary fat increased the diurnal
circulating leptin pulse amplitude (peak minus nadir plasma
leptin concentration).
Although
leptin reduces appetite, obese individuals generally exhibit an unusually high
circulating concentration of
leptin.
Low dose
leptin administration reverses effects of sustained weight - reduction on energy expenditure and
circulating concentrations of thyroid hormones.