Additionally, as a heartworm preventative,
circulating milbemycin oxime has been shown to disrupt the nervous system of heartworm larvae, leading to their demise.
Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with
milbemycin oxime carrying a high number of
circulating offspring (microfilariae).