It is well - established that influenza vaccines are less effective in «mismatched» seasons when the main
circulating strains change after the months - long vaccine production process has already begun.
Not exact matches
In some cases, the mutations produced the same amino acid
change in both the cancer patients» and the global virus
strains circulating after 2010.
The findings, which appear in the March 11 issue of Cell Host & Microbe, contradict previous reports from Indian health officials that the
strain has not
changed from the version of H1N1 that emerged in 2009 and has been
circulating around the world ever since.
The vaccine used during the 2012 — 13 flu season in Canada did not work very well, despite the fact that the
circulating flu viruses had not seemingly
changed much after the vaccine
strains had been chosen.
Changes to the flu
strains circulating around the Northern Hemisphere explain why last year's flu vaccine didn't work so well.
So, due to natural
changes in the virus as it evolves, as well as due to mutations that may be caused by growing the vaccine
strain, the
circulating virus and the vaccine become less well matched over time.