Sentences with phrase «circulating tumour»
The team is currently working on genome sequencing of individual circulating tumour cells from patients at the Vancouver Prostate Centre.
http://news.ubc.ca/
Kelley, lead investigator on the study published today in Nature Chemistry, explained how her team has advanced a completely new approach using magnetic nanoparticles with DNA capture probes on their surface that can target circulating tumour cells (CTCs) in blood samples to see if the cells contains biomarkers associated with drug resistance.
Professor Dive's exhibit was designed to introduce visitors to the concept of circulating tumour cells (CTCs) and how liquid biopsies could hold the key for better diagnosis and treatment of lung cancer.
The DNA from cancer cells is mutated and this mutated DNA can get into the blood stream (circulating tumour DNA, ctDNA) and be detected by sequencing the DNA in blood.
Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations.
The sensitivity for detecting the presence of genomic changes in circulating tumour DNA (ctDNA) is limited by its low concentration in plasma.
It is hoped that these approaches will allow doctors to use circulating tumour DNA to tailor treatment for individual patients to get the best result.
In this early work they found they could see whether a patient was relapsing by tracking levels of circulating tumour DNA.
Olaparib stopped prostate cancer growth, generating falls in prostate specific antigen (PSA) levels, falls in circulating tumour cell counts in the blood, and radiological responses on CT scans and MRI.
Women who tested positive for circulating tumour DNA were at 12 times the risk of relapse of those who tested negative, and the return of their cancer was detected an average of 7.9 months before any visible signs emerged.
The researchers tested levels of this circulating tumour DNA in patients before and after treatment.
These results were facilitated by the permanent cultivation of circulating tumour cells of patients with advanced SCLC in Vienna.
This suggests that the presence of AR - V7 in circulating tumour cells does not preclude response to galeterone as has been shown to be the case for abiraterone and enzalutamide.»
«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.
We also detected circulating tumour cells, which were found in higher numbers in patients who had received more prior therapies.
«The circulating tumour DNA values in the blood samples identified the metastases on average 11 months before they were diagnosed by standard clinical procedures.
Researchers then looked in the blood samples for circulating tumour DNA (ctDNA) with the same fingerprint.
The researchers concluded that patients with circulating tumour cells with more N - terminals than C - terminals had the androgen receptor variants.
Not exact matches
«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.