Sentences with phrase «circulating virus strains»

«The matching process is not a perfect science, therefore, in some flu seasons, the vaccine available in the fall is not a good match for the circulating virus strains and is less effective,» said senior author David Weiner, Ph.D., Executive Vice President and Director of the Vaccine and Immune Therapy Center at The Wistar Institute.

Flu vaccines work by introducing a killed version of circulating virus strains, which trains the body's immune system to recognize and attack similar invaders in the future.

«There were a couple of these in the vaccine strain the past two seasons that wound up making it a little bit different from the actual circulating virus strain.»

Not exact matches

Both drift and shift make these proteins unrecognizable to the antibodies present in people that were previously inoculated against the flu virus, which now circulates as more than 90 strains.

In some cases, the mutations produced the same amino acid change in both the cancer patients» and the global virus strains circulating after 2010.

The study also confirms that the «H1» hemagluttinin protein of the new virus derives from the classical swine H1N1 strain, which shares a close common ancestor with the human H1N1 strain circulating before 1957 and several lines of evidence show that older people exposed to that virus may have some immunity to the new H1N1.

They tested a strain of Zika virus currently circulating in human populations in the Americas and another from Africa, which is the original strain identified in 1947.

That's because there are multiple strains of flu viruses circulating at any one time, said Dr. William Schaffner, an infectious - disease specialist at Vanderbilt University Medical Center in Nashville.

«It was not known whether any of these vaccines could provide protection against the new outbreak West African Makona strain of Ebola Zaire currently circulating in Guinea,» said John Eldridge, Chief Scientific Officer - Vaccines at Profectus Biosciences, Inc. «Our findings show that our candidate vaccines provided complete, single dose protection from a lethal amount of the Makona strain of Ebola virus.»

The assay offers rapid, specific, sensitive, and inexpensive detection of the Asian - lineage Zika virus strain that is currently circulating in the Western hemisphere, and can also detect the African - lineage Zika virus strain using separate, specific primers.

Human placental cell line Jeg - 3 can be readily infected by a circulating strain of Zika virus (left panel) and completely protected by treatment with nanchangmycin (right panel).

A small number of people infected with HIV produce antibodies with an amazing effect: Not only are the antibodies directed against the own virus strain, but also against different sub-types of HIV that circulate worldwide.

Those annual shots remain the best means of protection, but they must be manufactured months before flu season starts, based on a best educated guess of what strains of the virus will be circulating.

«With the 1918 - 1919 flu season, older patients had some memory immunity to the virus because a similar strain had circulated years before.

Today's flu vaccines make the immune system produce antibodies that recognise structures on the surface of the virus to prevent infection with the most prevalent circulating strains.

In any given season, the effectiveness of the vaccine depends on how good a match there is between the viruses used in the drug's production and the strains that are actually circulating that year.

While only a few strains of flu virus circulate worldwide in a typical year, dozens more may exist.

Despite rigorous modeling practices, the virus in the vaccine occasionally doesn't match the circulating strain of influenza.

So H1N1 in itself is a, you know, broad category of viruses that circulate in humans, even now; they are not as fearsome as the original strain when it first emerged.

For the new study, researchers in Diamond's laboratory, led by first author Helen Lazear, PhD, now at the University of North Carolina at Chapel Hill, tested five strains of the Zika virus in the mice: the original strain acquired from Uganda in 1947; three strains that circulated in Senegal in the 1980s; and the French Polynesian strain, which caused infections in 2013 and is nearly identical to the strain causing the current outbreak.

He has long advocated global cooperation in the surveillance of circulating flu viruses to spot emerging new strains so public health officials could plan a response and drug companies could get a head start in making vaccines.

The vaccine was targeted especially toward the virus strain circulating in Thailand, and it may not show the same effectiveness where the virus is different, such as Africa or the U.S. And even the 31.2 percent fewer cases that it resulted in is hardly an ideal preventative strategy.

The Human Immunodeficiency Virus (HIV) mutates very rapidly and circulates in many different strains.

These rare VDPVs arise when a virus used in the live vaccine reverts from its weakened form and regains its virulence — a danger when vaccination rates are low, as they are in both places, allowing the vaccine strain to circulate and accumulate genetic mutations.

This could be due to antigenic mismatch between the circulating influenza viruses and the vaccine strains recommended by the WHO.

While this year's vaccine is a much better match to the circulating seasonal strains of influenza, the shifty nature of the virus and the need to pick the viruses used to make global vaccine stocks well before the onset of the flu season can make vaccine strain selection a shot in the dark.

Writing this week (May 23, 2016) in the journal Nature Microbiology, a team of researchers led by University of Wisconsin - Madison School of Veterinary Medicine virologist Yoshihiro Kawaoka describes a novel strategy to predict the antigenic evolution of circulating influenza viruses and give science the ability to more precisely anticipate seasonal flu strains.

That includes tracking the myriad flu strains circulating globally each year in animals and using the data to help develop candidate vaccine viruses.

Called a DNA vaccine, it contains genetic snippets from a Zika virus strain that circulated recently in Brazil to elicit immune responses.

The vaccine used during the 2012 — 13 flu season in Canada did not work very well, despite the fact that the circulating flu viruses had not seemingly changed much after the vaccine strains had been chosen.

How much protection the annual flu shot provides depends on how well the vaccine (which is designed based on a «best guess» for next season's flu strain) matches the actually circulating virus.

The strain likely resulted from a reshuffling of several avian influenza viruses circulating in domestic ducks and chickens, Guan's group reported in 2013.

The viral strain was almost identical to one that circulated in humans in 1995, suggesting the virus had entered the seal population in that year and remained the same ever since.

In the case of flu, most people had antibodies to seasonally circulating influenza strains, but these antibodies were a poor match to the pandemic virus.

The virus strains» family trees suggested that flu always circulates locally in east Asia before emerging from this crucible for its global excursions.

The virus itself will continue to mutate from year to year — a process referred to as antigenic drift — and over time it becomes less well matched to the vaccine strain, meaning that the antibodies you generate from getting the vaccine may be less effective in neutralizing the circulating virus.

So, due to natural changes in the virus as it evolves, as well as due to mutations that may be caused by growing the vaccine strain, the circulating virus and the vaccine become less well matched over time.

2009 — Developed an MVA HIV Vaccine Candidate — MHRP and NIAID researchers developed a new HIV vaccine, specific to the strain of HIV circulating in Southeast Asia that is expressed in a modified smallpox virus vector (MVA).

The new bivalent vaccine helps protect dogs against the two strains of the virus known to be circulating in the U.S., CIV H3N2 and CIV H3N8.

«Pfizer Animal Health is committed to monitoring swine influenza viruses and bringing to the market vaccines that help protect against SIV strains circulating in pork production systems today,» said Kuhn.

It was recently brought to our attention that there are rumors circulating online about the existence of two new strains of canine distemper virus.

The outbreak in the Midwest had been attributed to the H3N8 strain of virus, which was identified in the U.S. dog population in 2004 and has been circulating since.

From the American Veterinary Medical Association: It was recently brought to our attention that there are rumors circulating online about the existence of two new strains of canine distemper virus.