Sentences with phrase «cisplatin in»

The sponge is a biodegradable polymer, which slowly breaks down in the body, releasing cisplatin in very high concentrations to the tissues in the surgery site.

Weekly irinotecan and cisplatin in advanced non-small cell lung cancer: A phase II multicenter study.

MKP1 / CL100 controls tumor growth and sensitivity to cisplatin in non-small-cell lung cancer.

In this case, the cisplatin in the triple threat nanoparticle is delivered the instant the particle enters the cell, as it reacts to the presence of an antioxidant found in the cells called glutathione.

IP5 worked as well as cisplatin in reducing the volumes of the tumors, the team reports today in Cancer Research.

One of these, UJ3, is as effective as the industry - standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer and melanoma.

Moreover, use of the gel led to significantly lower levels of cisplatin in liver tissue 5 centimetres away from the cancer, and in the kidneys.

Not exact matches

A sick husband in a hospital bed getting Mitomycin, Cisplatin and Velban dripped into him.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

Cisplatin is used to treat a variety of cancers but causes irreversible hearing loss in up to 70 % of patients.

In the case of cisplatin - induced hearing loss, kenpaullone appears to protect hair cells by preventing CDK2 from stimulating the production of toxic reactive oxygen species from the cells» mitochondria.

They used interferon, a type of small protein, to manipulate the pathways involved in cisplatin.

In early studies on rabbits, the anticancer drug cisplatin, a simple but highly toxic chemical containing platinum, was added to Intradose CDDP.

The addition of necitumumab to gemcitabine and cisplatin chemotherapy improved overall survival and progression free survival by 21 % and 16 %, respectively, as compared to chemotherapy alone in patients whose tumours expressed the EGFR protein.

Patients with epidermal growth factor receptor (EGFR) expressing advanced squamous non-small-cell lung cancer benefit most from necitumumab added to gemcitabine and cisplatin chemotherapy, according to a subgroup analysis from the SQUIRE trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland.

«Given that pemetrexed combined with cisplatin may be less toxic than and as active as cisplatin plus paclitaxel and that it can be combined with bevacizumab, investigating the comparison of cisplatin - pemetrexed plus bevacizumab with cisplatin - paclitaxel plus bevacizumab would be the next appropriate step,» said Dr. Miller, who holds the Amy and Vernon E. Faulconer Distinguished Chair in Medical Science and the Dallas Foundation Chair in Gynecologic Oncology.

They used this method first in 2015 to generate a UV repair map of the human genome, and in 2016 they used the XR - seq method to generate the damage and repair maps of the anticancer cisplatin drug for the entire human genome.

In the Cancer Cell article, the researchers describe how various anticancer drugs, including cisplatin and the targeted therapy vemurafenib, which targets melanomas with the BRAF mutation, become more effective when co-delivered with phenformin.

Cisplatin and cyclophosphamide were the other drugs used in this study.

In contrast, because of the high incidence of TP53 mutations in the HPV - inactive class, these tumors may be less responsive to the standard cisplatin chemotherapy and more sensitive to other chemotherapies such as dasatinib.&raquIn contrast, because of the high incidence of TP53 mutations in the HPV - inactive class, these tumors may be less responsive to the standard cisplatin chemotherapy and more sensitive to other chemotherapies such as dasatinib.&raquin the HPV - inactive class, these tumors may be less responsive to the standard cisplatin chemotherapy and more sensitive to other chemotherapies such as dasatinib.»

Sorenseon DN, Dakup PP, Gaddameedhi S. Chronopharmacology of cisplatin: Role of the circadian rhythm in modulating the cisplatin transporters levels [published online April 2016].

Cisplatin regulates cell autophagy in endometrial cancer cells via the PI3K / AKT / mTOR signalling pathway.

In specific, in the intratumoral groups the cisplatin concentration was high immediately after administration, while in the aerosol cisplatin groups the concentration was significantly loweIn specific, in the intratumoral groups the cisplatin concentration was high immediately after administration, while in the aerosol cisplatin groups the concentration was significantly lowein the intratumoral groups the cisplatin concentration was high immediately after administration, while in the aerosol cisplatin groups the concentration was significantly lowein the aerosol cisplatin groups the concentration was significantly lower.

In the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with human ABCA10 transgene (Ad - h - ABCA10) purchased from Vector Labs ® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatiIn the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with human ABCA10 transgene (Ad - h - ABCA10) purchased from Vector Labs ® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatiin order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.

The viral vector and aerosol cisplatin was safe as aerosol administration to the lung parenchyma as observed in Figure 1.

Aerosol administration was performed as follows, the residual cup was filled with 8mls of the cisplatin agent and the nebulisation time was 10 minutes (almost 1 ml / minute) as observed from our previous studies.14 The aerosol was delivered to the mice (one by one) within a nose only cage that has been previously presented.34 In the groups receiving the intratumoral cisplatin an insulin injection was used to deliver the 2mls of cisplatin within the tumor in different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulateIn the groups receiving the intratumoral cisplatin an insulin injection was used to deliver the 2mls of cisplatin within the tumor in different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulatein different depths, however; a quantity of the drug when the injection was made superficially was lost since it was not accumulated.

Zoledronic acid reverses cisplatin resistance in nasopharyngeal carcinoma cells by activating the mitochondrial apoptotic pathway.

Phase I / II Study of Cisplatin plus Romidepsin and Nivolumab in Metastatic Triple Negative Breast Cancer or BRCA Mutation - Associated Locally Recurrent or Metastatic Breast Cancer

Identification of small molecule inhibitors of Cisplatin - induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

The study included 44 patients in the sunitinib group and 41 patients in the placebo group; all received a chemotherapy regimen of cisplatin or carboplatin and etoposide after enrollment but prior to randomization.

Combined niclosamide with cisplatin inhibits epithelial - mesenchymal transition and tumor growth in cisplatin - resistant triple - negative breast cancer.

Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells.

The first relies on the biochemical properties of a drug, while the second uses the antigen / antibody connection.26 The use of biotynilated - epidermal growth factor (EGFR) has been used to enhance the accumulation of cisplatin.27 Other local factors in the respiratory system influencing the absorption are the local transporters and genes.

Inhibition of ERβ Induces Resistance to Cisplatin by Enhancing Rad51 — Mediated DNA Repair in Human Medulloblastoma Cell Lines.

The use of biotinylated - EGF - modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation.

The aerosol administration was time consuming needing in total ten minutes for nebulisation of 2mls of cisplatin.

Inhaled cisplatin deposition and distribution in lymph nodes in stage II lung cancer patients.

However; we should emphasize that in the intratumoral groups the mice were killed five minutes after administration, while in the aerosol cisplatin groups fifteen minutes since the initiation of the administration.

The structure of these transporters is essential to the rational design of agents which control their function.30 - 32 In our current work we investigated the chemotherapy agent cisplatin since it the most used chemotherapy drug for a number of cancer types and the application would have an impact on several cancers.

We additionally used mice in order to acquire the necessary tissue samples in order to evaluate the cisplatin concentrations within the tissue.

In combination with cisplatin, niclosamide inhibited epithelial - mesenchymal transition (EMT) and tumor growth in triple - negative breast cancer [34In combination with cisplatin, niclosamide inhibited epithelial - mesenchymal transition (EMT) and tumor growth in triple - negative breast cancer [34in triple - negative breast cancer [34].

Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity.

Short Research Communication The Factors Reducing Relative Dose Intensity of Cisplatin and Vinorelbine as Adjuvant Chemotherapy in Patients with Non-Small Cell Lung Cancer Ryo Inose, Katsuyuki Takahashi, Naruo Yoshimura, Tomoya Kawaguchi, Mitsutaka Takada, Katsuya Nagayama Oncomedicine 2018; 3: 9 - 14.

The only randomized study of adjuvant chemotherapy in mucosal melanoma demonstrated significantly increased relapse - free and overall survival in patients receiving temozolomide and cisplatin, as compared with interferon alfa - 2b or observation.

[61,62] Small retrospective studies of biochemotherapy (cisplatin, vinblastine, dacarbazine, interferon alfa - 2b, and IL - 2) also demonstrated activity that was similar in cutaneous and mucosal melanomas.

Correlative nanomechanical profiling with super-resolution F - actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells Sharma S, Santiskulvong C, Bentolila, L A, Rao J, Dorigo O and Gimzewski J K 2012 Nanomedicine: Nanotechnology, Biology, and Medicine 8 757 - 766

Title: Tumor - initiating cells are not enriched in cisplatin - surviving BRCA1; p53 - deficient mammary tumor cells in vivo Authors: Pajic M, Kersbergen A, van Diepen F, Pfauth A, Jonkers J, Borst P, Rottenberg S Date: 2010 Publication Details: Cell Cycle.

8/27/2008 Variation of Normal Protein Could Be Key to Resistance to Common Cancer Drug Researchers at the Moores Cancer Center at the University of California, San Diego (UC SD) in La Jolla have found evidence explaining why a common chemotherapy drug, cisplatin, may not always work for every cancer patient.

All patients enrolled in the study were ineligible for cisplatin because of medical frailty.

Cisplatin, a commonly used chemotherapeutic reagent in lung cancer treatment (Wang and Lippard, 2005; Chattopadhyay et al., 2006), was utilized to treat the cells.