Since the mid-2000s, the voltage-gated sodium channel NaV1.7 has emerged as a promising target for a new
class of analgesics.
Not exact matches
The study focused on various
classes of drugs used to treat pain (
analgesics) and insomnia (hypnotics), as well as drugs to treat anxiety and depression.
The scientists discovered that a
class of mechanoreceptors in the skin that detect painful mechanical stimuli are part
of a feedback circuit in which excitatory neurons that produce the hormone somatostatin are inhibited by neurons that synthesize dynorphin (a natural
analgesic molecule that produces effects similar to opiates).
While new
classes of safer
analgesics may be on their way («Build a Better Painkiller,» Winter 2017), clinicians need other options now, and many appear to be turning to gabapentinoids, including Neurontin (gabapentin) and Lyrica (pregabalin).