Now, the research team has developed a reaction to produce an important
class of compounds in pure left - or right - handed form.
Given the failure of the pipeline for conventional antibiotics, scientists have been looking at the bacteria - killing potential of
other classes of compounds.
During the screening, companies look for compounds, or more
likely classes of compounds, with the desired activity, which are called hits.
Tea contains hundreds of chemical compounds and one
class of compounds known as catechins are responsible for the amazing anticancer properties of green tea.
«We are also using the same high throughput screening technology to investigate a collection of more than 200,000 completely novel compounds with as yet uncharacterized biological activity in the hopes of identifying
new classes of compounds with potent activity against CRE and other multi-drug resistant pathogens,» Kirby said.
A
novel class of compounds developed by a University of Saskatchewan (U of S)- led research team could yield more effective and less toxic chemotherapy drugs to treat cancer.
So - called «ivermectin» sensitivity is actually sensitivity to a
broad class of compounds due to a basic defect in the blood - brain barrier.
But the fastest - growing trend is a more
complicated class of compounds brewed up by trained chemists like Patrick Arnold who are searching for exotic steroids or pursuing novel psychoactive compounds.
There is a real feeling that we have to totally reinvent things in order to come up with [new
classes of compounds], and the best way to handle that is to have understanding between the disciplines,» she says.
As a result of this screen, Dr. Rubin's group discovered
several classes of compounds that elevate SMN protein levels in SMA patient fibroblasts and motor neurons deficient for SMN.
In that study, the researchers analyzed many more bacteria than did Duan, Shen, and coworkers, but they didn't know in advance
what class of compounds they were searching for.
Check for the
pyrethroid class of compounds and be sure that such compounds are either not in the flea medications or mosquito / insect repellents used around your cats (there are no safe mosquito repellents for cats, but you should nevertheless learn how to keep your cat safe from heartworms) or that the compounds are in a collective concentration — meaning you'll need to consider the total of all pyrethroid compounds — that falls below the typically safe level of 1 %.
The Institute sent the bacterial isolate to Merck Sharp & Dohme Research Laboratories in Rahway, NJ, where it was discovered that it was a
particular class of compound called avermectin secreted by the bacteria that was responsible for its ability to kill worms.
The new JCAP photocathode construct consists of the semiconductor gallium phosphide and a molecular cobalt - containing hydrogen production catalyst from the
cobaloxime class of compounds.
For example, Lilly's Notice ignores the fact that its olanzapine patent was a selection (from a known
general class of compounds), and that Lilly had specifically stated in its patent (to back up its selection) that olanzapine has «marked superiority and a better side effects profile than prior known antipsychotic agents, and... a highly advantageous activity level.
(GlaxoSmithKline has decided to stop marketing ezogabine but other existing drugs that also operate by tweaking potassium channels in brain cells — or a wholly
new class of compounds — could serve in its place.)
During this innovative study published in PLOS One, researchers found that
novel classes of compounds, such as metal - complexes, can be used as alternatives to or to supplement traditional antibiotics, which have become ineffective due to antimicrobial resistance.
Both of these recent studies are useful, but they are limited in their predictive capability, and especially in transferability of their conclusions and suggestions to
other classes of compounds, which is simply because neither of these studies identified the fundamental molecular properties involved in determining a molecule's radiative efficiency and how these might be used to identify strategies for minimizing a molecule's radiative efficiency.
In conclusion the FCA upheld the Judge's conclusion that the patent claims fail the requirement for product specificity because they do not make specific reference to the medicinal ingredient rilpirivine, but only the
broad class of compounds, but the FCA did so under section 4 (2)(a) rather than 4 (2)(b).
«The research opens up opportunities for using different reagents in nano - DESI, allowing for detailed analysis of
different classes of compounds in bewilderingly complex mixtures,» said Dr. Sergey A. Nizkorodov, an Associate Professor of chemistry at University of California, Irvine.
Minoryx is also working on a new
class of compounds: non-competitive pharmacological chaperones, identified through its innovative proprietary platform — SEE - Tx.
Monk Fruit: Monk fruit gets its sweetness from
a class of compounds called mogrosides.
Coconut fiber belongs to
the class of compounds known as flammable solids.
While all humans have background exposure to dioxins at a level not expected to affect human heath, the WHO is especially concerned about the highly toxic potential of
this class of compounds, which can cause lead to cancer and reproductive and developmental problems, including damage to the immune system and interference with hormones.
Among the most promising are the ampakines,
a class of compounds that keep glutamate receptors open longer, allowing more of that critical neurotransmitter to enter the cell.
The class of compounds studied includes those used by some plant pathogens to coordinate their attacks.
And SumiShield is a neonicotinoid,
a class of compounds that faces public opposition because it has been implicated in the mass die - off of pollinators.
3BP, part of
a class of compounds known as small molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.
Sulfites,
a class of compounds including sulfur dioxide and sulfite salts, act as antioxidants and antibacterial compounds.
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) describe
a class of compounds with the potential to stop chronic itch without the adverse side effects normally associated with medicating the condition.
Biologics —
a class of compounds created by biological processes instead of chemistry — include a range of antibodies, interleukins (proteins and molecules critical to the function of the immune system), and vaccines.
There have been controversial claims that exposure to
a class of compounds called endocrine disruptors — chemicals that can act like hormones — has caused damage to wildlife, including a report that alligators that live in a polluted Florida lake have abnormally small penises.
A relatively new
class of compounds, neonicotinoids not only can kill bees but also have «sublethal» effects on their behavior and foraging and come into contact with bees in different ways than older pesticides do, environmentalists worry.
By comparing to profiles of known drugs, the researchers found a match with
a class of compounds called polyethers, which possess anticancer activity.