The finding suggests a new
class of molecule that may be useful for developing antiviral treatments.
Magnetic «bait» reagents may be constructed from proteins, cytokines, carbohydrates, pharmaceuticals, aptamers or nearly any other
class of molecule.
«We've developed a chemical technique, based on a new discovery in gold chemistry, that lets us attach a radioactive fluorine atom to a specific
class of molecule that was previously challenging to do,» Levin said.
I would guess that this mechanism helps ensure balance in what the animal can detect, so that, if it's getting a lot of information about a particular
class of molecule, it turns down that channel of information and that leaves more capacity to pick up other cues that it's not detecting as well right now.»
However, the infrared emission only indicates the general
class of molecule, and identifying which specific molecular species are present is difficult.
The objects of his study range from
a class of molecules that have the basic self - duplicating property of living things, through cells which suggest purely physical systems, through animals which give increasing evidence of having minds, to human beings in whom streams of consciousness seem to involve continual choices of action, at the opposite pole from control by impersonal laws of nature.
They found that this fear - inducing chemical, a new
class of molecules called sulfolipids, could activate four redundant brain circuits that led to this behavior.
The new results point to sulfites and bisulfites as a new
class of molecules — ones that were actually available on early Earth — that chemists can now test in the lab, to see whether they can synthesize from these molecules the precursors for life.
Their particular focus was
a class of molecules, called aromatic hydrocarbons, that are distinguished by their stability and restrained reactivity.
The researchers found that
a class of molecules called sulfidic anions may have been abundant in Earth's lakes and rivers.
Researchers have found that
a class of molecules called sulfidic anions may have been abundant in Earth's lakes and rivers.
«And that allows us to control the intramolecular motion of the photoswitch with a degree of precision never before achieved for
this class of molecules» says Dube.
«Enhancer RNAs alter gene expression: New
class of molecules may be key emerging «enhancer therapy».»
Jena had already been working for more than five years on superhalogens,
a class of molecules that mimic the chemistry of halogens but have electron affinities that are much larger than that of the halogen atoms.
These classes of molecules are commonly found near the ocean's surface, and they are ubiquitous in biology.
A class of molecules in the cell called chaperones have the job of binding to parts of proteins that come unfolded, and the researchers found that the unfolded protein interacted more with chaperones than did the properly folded protein.
University of Illinois chemist Martin Burke, a pioneer of a technique that constructs complex molecules from simple chemical «building blocks,» led a group that found that thousands of compounds in
a class of molecules called polyenes — many of which have great potential as drugs — can be built simply and economically from a scant one dozen different building blocks.
According to Professor Zink from Eurac Research, the microRNAs are the next important
class of molecules from Ötzi to receive intensive examination.
BET proteins can have a huge impact on gene activity because they belong to
a class of molecules called epigenetic readers, which recognize special marks on DNA - protein complexes and attract gene - activating proteins to those spots.
Wentrup adds that very recently his team also found the first evidence for the existence of yet
another class of molecules — the bisimines, RN = C = C = C = NR».
Based on a plant - based
class of molecules known as indoline alkaloids, the compound inhibits an enzyme called polymerase, which enables a virus to make thousands of copies of itself and cause disease, explains Claire Marie Filone, the study's lead author.
The compound is part of
a class of molecules called «Criegee biradicals,» named after the scientist Rudolf Criegee, who predicted their existence in 1949.
His work helped discover
a class of molecules called core protein allosteric modulators, or CpAMs, that disrupt capsid protein assembly.
«There's a whole
class of molecules that's not in our combustion models,» says Taatjes.
Using a thermal stability assay, we identified
a class of molecules that bind α - crystallins (cryAA and cryAB) and reversed their aggregation in vitro.
The genes involved encode proteins that control the activity of a very important and ubiquitous
class of molecules that are a major target of pharmacologic agents across medicine,» says Ethan Goldberg, MD, PhD, an attending physician and instructor of neurology at the Children's Hospital of Philadelphia and The Perelman School of Medicine at The University of Pennsylvania.
We found that CD1 glycoproteins,
a class of molecules responsible for the presentation of self and foreign lipids, are coordinately regulated by PPARγ activation.
IBM researchers engineered
a class of molecules called block copolymers to self - assemble into dense patterns to extend the capabilities of photolithography.
This indicates that a small or electron - withdrawing group at position 4 on D - Phe1 positively affects the activity of
this class of molecules.
Furthermore, in order to optimize the pharmacokinetic profile and to improve CXCR4 binding affinity of
this class of molecules, dual pyrimidinyl compounds, substituted with different functional groups such as methoxy and morpholine, were synthesized (compounds 194 - 200).
DNA is one of
a class of molecules called nucleic acids.
So, the existing treatments are all
a class of molecules called anti-VEGF drugs.
«This work represents a major advance because it provides a framework for studying lincRNAs, a poorly understood, but abundant
class of molecules,» says Michael Bender, who oversees RNA processing and function grants at the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the work.
Attention fell on
a class of molecules called «reactive oxygen species,» or ROS.
Not exact matches
It would build expertise and develop technology platforms to support drug development, while pursuing a new
class of large -
molecule biological drugs tailored to certain conditions, enabling the long - sought dream
of personalized medicine.
That is to say, for complete homogeneity all the members
of a
class have to be at the absolute zero point
of the temperature scale so that their
molecules are in the ground state.
The apparent gap between nonliving and living has now been bridged by nucleic acids, a
class of polymeric organic
molecules composed
of a succession
of small units (nucleotides)
of four sorts, the order
of which determines an indefinitely large number
of different specificities.
The
molecule in question, known as beta - 2 microglobulin, or B2M, is a component
of a larger
molecule called MHC I (major histocompatibility complex
class I), which plays a major role in the adaptive immune system.
To address this problem, the research team prepared a new family
of molecules with C = M = C cores where the metal was cerium [
classed as a lanthanide] or thorium or uranium [which are
classed as actinides] where two carbon atoms that are known to be strong donors were forced to be opposite to one another either side
of the metal.»
The new research, published recently as two separate studies in ACS Central Science and the Journal
of the American Chemical Society, demonstrates that a new
class of drugs called small
molecule RNA inhibitors can successfully target and kill specific types
of cancer.
A viral epitope inserted into the complementarity - determining region 3 (CDR3) loop
of the heavy chain
of a self immunoglobulin (Ig)
molecule was generated from the Ig context and was presented by I - Ed
class II
molecules to virus - specific, CD4 + T cells.
Gas - source isotope ratio mass spectrometers are a special breed
of a
class of instruments — mass spectrometers — that are used in many different areas
of science, from physics to biomedical science, for the separation
of atoms and
molecules of different charges and molecular weights.
A
class of small
molecules found in grapes, red wine, olive oil, and other foods extends the life
of yeast cells by approximately 70 % and activates genes known to extend life span in laboratory animals.
In this study, the SIgN team discovered for the first time that the integrity
of p53 affects the production
of a special cell surface protein called Major Histocompatibility Complex (MHC)
class I. MHC
class I
molecules on the cancer cell surface serve as targets for the immune system.
3BP, part
of a
class of compounds known as small
molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.
Jo Ellen Roseman, director
of the long - term science literacy project, said improved ways
of teaching how atoms and
molecules behave in chemical reactions will prepare students for more advanced
classes in high school and college.
In 1991, Japanese researchers discovered that Lion's Mane contains two novel
classes of nerve growth factor —
molecules called hericenones and erinacines — that stimulate the differentiation and re-myelination
of neurons.
Biologics — a
class of compounds created by biological processes instead
of chemistry — include a range
of antibodies, interleukins (proteins and
molecules critical to the function
of the immune system), and vaccines.
They demonstrated that their machine could build 14 different
classes of small
molecules, including ones with difficult - to - manufacture ring structures, all using the same automated building - block assembly.
Different
classes of MHC
molecules exist and are involved in immunity against pathogens and tumor cells as well as the formation
of immune tolerance to self - antigens.