Sentences with phrase «class of proteins called»

Perform an experiment that demonstrates how we can harness the catalytic power of a hard - working class of proteins called enzymes in industry.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

To find out, she and her MIT colleagues targeted a class of proteins called TRPV1 channels, which are found in neurons that respond to heat and certain chemicals in food.

Cry4 is part of a class of proteins called cryptochromes, which are known to be involved in circadian rhythms, or biological sleep cycles (SN: 10/02/17, p. 6).

Aiolos is a member of a class of proteins called transcription factors — proteins that control which genes are turned on or off by binding to DNA and other proteins.

Not exact matches

The largest class of human target proteins for drugs are the so - called G - protein - coupled receptors.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

They've been bred to lack proteins — members of a family called MHCI (which stands for major histocompatibility complex class I)-- crucial to fighting pathogens.

Ovaa and Neefjes» team decided to look at another class of proteins, called phosphatases, that act in the opposite way from kinases to see if inhibiting them would have a similar effect.

Six years ago, Tanzi and neuroscientist Robert Moir, also at MGH, decided to test a hunch that ß amyloid behaves similarly to a class of proteins with well - known beneficial properties, called antimicrobial peptides, or AMPs.

Sonnenberg, Hepworth, and their colleagues deleted a protein called RORγt, required for one class of ILCs, in mice.

A class of molecules in the cell called chaperones have the job of binding to parts of proteins that come unfolded, and the researchers found that the unfolded protein interacted more with chaperones than did the properly folded protein.

These biologic therapies use an antibody class called immunoglobulin - G (IgG) to bind to and prevent the activity of specific proteins or growth factors.

In 2012, a group from the RIKEN Center for Life Science Technologies, in collaboration with SISSA, an Italian University, discovered a new class of mouse lncRNAs, which are called «antisense» because their can pair with typical protein - coding mRNAs and enhance their translation.

BET proteins can have a huge impact on gene activity because they belong to a class of molecules called epigenetic readers, which recognize special marks on DNA - protein complexes and attract gene - activating proteins to those spots.

The most notorious example of this class is HIV proteinase, commonly called HIV protease, which helps the virus cut a long polypeptide into functional proteins; it has become the target of several successful AIDS drugs.

Despite the substantial differences between these two classes of natural products, each is synthesized biologically under the control of exceptionally large, multifunctional proteins termed polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) that contain repeated, coordinated groups of active sites called modules, in which each module is responsible for catalysis of one complete cycle of polyketide or polypeptide chain elongation and associated functional group modifications.

His work helped discover a class of molecules called core protein allosteric modulators, or CpAMs, that disrupt capsid protein assembly.

Dr. Yang's team has developed the new class of protein - based contrast agents and tested one called ProCA32 that enabled a much earlier detection of liver cancer tumors in mice.

In the course of seeking new treatments for brucellosis, scientists discovered that Brucella contains a class of signaling proteins called LOVs.

The multidisciplinary team of researchers from the Centre for Developmental Neurobiology (CDN) at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), and the MRC Centre for Neurodevelopmental Disorders (MRC CNDD), found that a particular class of basket cells does not function properly in the absence of a protein called ErbB4, making and receiving fewer connections with other neurons.

These therapies, the first an antibody and the second of a class called tyrosine kinase inhibitors (TKIs), reduce the ability of a target gene to manufacture the protein it encodes.

In their recent study, the UCSF team reports the discovery that a class of commonly prescribed Type - 2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of white fat cells into brown (in mice and culture dishes) by stabilizing the PRDM16 protein.

Sirt4 belongs to a class of proteins, called sirtuins, known to regulate aspects of longevity, metabolism, genome stability, diabetes and neurodegeneration.

piRNAs are small RNA molecules (26 - 31 nucleotides in length) that bind to a class of germline - specific proteins called PIWIs.

Hopes have been highest for a class of compounds called histone deacetylase (HDAC) inhibitors, which turn off proteins that shut down gene expression.

Dr. Vilcek's contributions to the understanding of proteins that control the body's defenses were instrumental in the development of the anti-inflammatory drug Remicade ®, the first member of a new class of therapeutics called TNF blockers that are now widely used for the treatment of Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, and other chronic inflammatory disorders.

This is accomplished by a class of enzymes called protein arginine methyltransferases (PRMTs).

A class of drugs called EZH2 inhibitors are currently in clinical development for both hematological malignancies and solid tumors and may be effectively targeted to epithelial ovarian cancers overexpressing the CARM1 protein.

In the latest issue of the Journal of Clinical Investigation, available today online, Dr. Farese and his team show how a protein called progranulin prevents a class of cells called microglia from becoming «hyperactive.»

In the study, functional Ikaros protein produced from the one remaining normal Ikaros gene was restored with a novel class of drugs that target a specific enzyme called casein kinase 2 or CK2.

In the New York Times bestseller The Plant Paradox, Dr. Steven Gundry introduced readers to the hidden toxins lurking in seemingly healthy foods like tomatoes, zucchini, quinoa, and brown rice: a class of plant - based proteins called lectins.

Called «pulses,» this unique class of protein - rich carbs includes lentils, chickpeas, and many varieties of beans.

One such class of profoundly problematic proteins belongs to a group called prolamins.