Sentences with phrase «classes of drugs by»

Current guidelines for asthma discourage the use of this class of drug by itself, rather than as a supplement to other asthma medications.

Not exact matches

In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDA.

Tecentriq belongs to a class of drugs called PD - 1 inhibitors, which help the immune system to fight cancer by blocking a mechanism that tumors use to evade attack.

(Reuters)- Alnylam Pharmaceuticals Inc's RNAi - based drug that targets a rare genetic disease met the main goal of a key study, in a breakthrough for the new class of medicines that works by blocking disease - causing proteins.

That cash doesn't include the money PhRMA's spending on the ongoing «Go Boldly» campaign, a series of TV, print and radio ads designed to polish the drug industry's image by reminding the public that drug companies do world - class research that brings disease cures to market to save lives.

A pharmacologist by training, I also knew that the bisphosphonates — a class of drugs developed for osteoporosis sufferers — were then being tested on OI patients.

This class of beer is regulated in the US by the TTB (Alcohol and Tobacco Tax and Trade Bureau), not the FDA (Food and Drug Administration), because they are «true beers» made from barley.

The Misuse of Drugs Act 1971, as amended by the Police Reform and Social Responsibility Act 2011, provides powers for enforcement agencies to deal with illicit manufacturers, suppliers and importers of temporary class dDrugs Act 1971, as amended by the Police Reform and Social Responsibility Act 2011, provides powers for enforcement agencies to deal with illicit manufacturers, suppliers and importers of temporary class drugsdrugs.

These included GBL (gamma - butyrolactone), BZP (Benzylpiperazine), and 15 anabolic steroids, testosterone - like products often used by sports people, all of which are now designated Class C drugs.

The following headlines splashed across the Mail: «The price of going soft on cannabis: Labour's experiment «pushed up hard drug use and crime», and the Telegraph: «Cannabis use soared by a quarter after Class C downgrade, study finds», and» «Softly softly» cannabis scheme drove up hospital admissions for hard drugs, study».

The government's decision in 2008 to reclassify cannabis as a Class B drug was highly controversial, not least because it rejected the findings of a review by the Advisory Council for the Misuse of Drugs carried out at the request of the Prime Minister.

The law would make selling more than 16 ounces of synthetic marijuana a Class C felony punishable by up to 5.5 years in prison and cause store owners to lose their liquor, tobacco and lottery licenses if they are caught selling the drug three times.

(GlaxoSmithKline has decided to stop marketing ezogabine but other existing drugs that also operate by tweaking potassium channels in brain cells — or a wholly new class of compounds — could serve in its place.)

3BP, part of a class of compounds known as small molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

The results of the study, funded by the Malaria Eradication Scientific Alliance (MESA), are published in one of the world's leading medical journals The Lancet Infectious Diseases, and show that adding high doses of ivermectin, an endectocide class of drug, to the antimalarial dihydroartemisinin - piperaquine (DP) had a major and prolonged effect on mosquito mortality.

In 2009, BMS took a big risk jumping into the immunotherapy field by acquiring the company Medarex, which brought with it Yervoy, a member of a new class of cancer drugs.

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trclass: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trclass of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trClass I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

Other types of medicines are already prescribed — and sometimes mandated by law — to treat sexual offenders, including other drugs that change testosterone levels and selective serotonin reuptake inhibitors, a class of antidepressants.

Breast cancer metastasis, the process by which cancer spreads, may be prevented through the new use of a class of drugs already approved by the U.S. Food and Drug Administration.

Ledipasvir belongs to a promising new class of DAA drugs that work by blocking the NS5A protein, which the hepatitis C virus also needs to replicate.

«Our data confirmed that, while the rate of growth of triple - negative breast cancer was not affected by CDK 4/6 inhibitors, this class of drugs was able to significantly inhibit the spread of triple - negative breast cancer to distant organs when tested in multiple different triple - negative breast cancer models, including patient - derived xenografts.»

With only one drug specifically approved for the treatment of lupus in the past 50 years, lupus patients are commonly treated with steroids, a class of immunosuppressive drugs that delay the development and progression of the disease by suppressing the immune system.

New findings by UH biomedical engineer Chandra Mohan and his team raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks and side effects often associated with current treatments.

New findings by a biomedical engineer and his team at the University of Houston (UH) raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks and side effects often associated with current treatments for this disease.

In the beginning of the century, the introduction of a new class of drugs for psoriasis, biologics, transformed the treatment of moderate - to - severe psoriasis by providing better skin clearance rates, low toxicity, and improved quality - of - life.

It is the most potent of the drugs in its class, and it works by interfering with the bone - breakdown process.

A class of drugs already approved by the U.S. Food and Drug Administration for treating rheumatoid arthritis is raising hairs in the research community — literally.

A team of University of Notre Dame researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin - resistant Staphylococcus aureus (MRSA) and other drug - resistant bacteria that threaten public health.

It also showed that the public cost of expanding public coverage for high - cost drugs — such as treatments for cancer and rheumatoid arthritis — would be modest and, under most plausible scenarios, would be offset by savings achieved in relatively common drug classes — like treatments for high cholesterol and high blood pressure.

This knowledge opens up new avenues to study unique stages of infectious cycle that are affected by inhibitor classes towards anti-parasitic drug development.

The findings make evacetrapib the third failure in a class of drugs known as cholesteryl ester transfer protein (CETP) inhibitors, which are designed to disrupt the natural process by which HDL cholesterol is converted into LDL cholesterol in the body.

Opiate addiction is largely controlled by the formation of powerful reward memories that link the pleasurable effects of opiate - class drugs to environmental triggers that induce drug craving in individuals addicted to opiates.

The study, led by a team in The Research Institute at Nationwide Children's Hospital, is the first of its kind to show these results from an exon - skipping drug — a class of therapeutics that allows cells to skip over missing parts of the gene and produce protein naturally.

«This means that patients who develop resistance to certain classes of chemotherapy can benefit from drugs that modulate histone marks such as histone deacetylase inhibitors, some of which are already approved by the Food and Drug Administration.

Taking that concept into biomedical research has yielded a breakthrough: This past May the mTOR inhibitor everolimus was approved by the U.S. Food and Drug Administration for the treatment of advanced pNET, the first drug in this class approved for this diseDrug Administration for the treatment of advanced pNET, the first drug in this class approved for this disedrug in this class approved for this disease.

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them.

This has been supported by studies showing a rapid response to selective serotonin reuptake inhibitors (SSRIs), a widely used class of antidepressant drugs.

A new class of drugs under development to treat depression has shown some success by targeting brain cells» ability to respond to the chemical messenger glutamate.

Yet this same fungus holds the promise of developing a new class of drugs which can control the way the body absorbs cholesterol, and so minimise the risk of heart attacks caused by a narrowing of the arteries.

Evolution In recent years, athletes including cyclists have used drugs called HIF stabilizers (hypoxia inducible factor), an emerging class of kidney - disease drugs that stimulate the body's own production of EPO by activating genes to express EPO.

PD -1-blocking agents such as nivolumab, pembrolizumab and atezolizumab are part of a class of drugs known as checkpoint inhibitors, and many cancer researchers are now trying to figure out how to enhance their activity by combining them with other types of drugs.

It's clear that the «safe haven» offered by the surrounding cells is triggered as a response to the same drugs that target this class of melanoma.

In their recent study, the UCSF team reports the discovery that a class of commonly prescribed Type - 2 diabetes drugs, called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of white fat cells into brown (in mice and culture dishes) by stabilizing the PRDM16 protein.

Tu also received numerous awards nationally which include «Award for Progress in Anti-malarial Research Achieved by Project 523 Scientific Team» honored by China National Congress of Science and Technology (1978); «National Scientific Discovery Award» for Anti-malaria Drug - Qinghaosu by the China Ministry of Science and Technology (1979); «Invention Award» (as the first inventor) by China National Congress for Awards in Science and Technology (1982); «Award of Young and Middle - aged Experts with Outstanding Contribution» by the Chinese Government (1984); «The Top Honorary Award» by China Academy of Traditional Chinese Medicine (1992); «The Top Ten National Achievements for Progress in Science and Technology» by China National Committee of Science and Technology (1992); «First - Class Award of National Achievements in Science and Technology» by China National Award Committee for Advances in Science and Technology (1992); «National Model» by China State Council (1995); «Award for Outstanding Achievement in Traditional Chinese Medicine» by Guangzhou Zhongjing Award Foundation for Traditional Chinese Medicine (1995); «Outstanding Scientific Achievement Award» by Qiu Shi Science and Technologies Foundation of Hong Kong (1996); «Top Ten Health Achievements in New China» by China Ministry of Health (1997); «Female Inventor of the New Century» by China National Bureau of Intellectual Property (2002); «Golden Medal of the 14th National Invention Exhibition» by China National Bureau of Intellectual Property (2003); «Award for Development of Chinese Materia Medica» by Cyrus Chung Ying Tang Foundation, (2009).

Paclitaxel, the first of a class of drugs known as taxanes, is approved by the FDA for the treatment of advanced ovarian cancer.

Recent research by Miettinen et al (2018) reveals that senescence induced by this class of drugs is mediated by proteasome hyper ‐ activation.

Ingber and his team found that a new class of drug being developed by GlaxoSmithKline could prevent pulmonary edema symptoms in the lung chip — and a separate study confirmed those results in animals.

The giant firms are counting on this class of drugs to bolster profits that will be hurt by the imminent expiration of patents on many small - molecule blockbusters.

Dr. Levin's lab is investigating a new class of drugs that are highly effective at keeping RGCs alive when the optic nerve is damaged by glaucoma.