«What has been a major puzzle in the CRISPR — Cas field is how Cas9 and similar RNA - guided complexes locate and recognize matching DNA targets in the context of an entire genome,
the classic needle in a haystack problem,» says Samuel Sternberg, lead author of the Nature paper and a member of Doudna's research group.
In a classic needle - in - the - haystack effort, Weinreich searched through thousands of grains from the famous high - titanium «orange soil» discovered by astronaut Harrison Schmitt during the Apollo 17 mission before finding ten that included melt inclusion
In a
classic needle -
in - the - haystack effort, Weinreich searched through thousands of grains from the famous high - titanium «orange soil» discovered by astronaut Harrison Schmitt during the Apollo 17 mission before finding ten that included melt inclusion
in - the -
haystack effort, Weinreich searched through thousands of grains from the famous high - titanium «orange soil» discovered by astronaut Harrison Schmitt during the Apollo 17 mission before finding ten that included melt inclusions.