Sentences with phrase «clearance of amyloid»

More recently, as scientists realized that IDE was also involved in clearance of amyloid - beta, they have begun searching for ways to supercharge the enzyme to see if it could prevent the build - up of the amyloid plaques that are a hallmark of Alzheimer's disease.

This year researchers finally demonstrated clearance of amyloid - β in humans, after a long series of failures.

CONCLUSION: In this Lewy body variant case, with globally stable functional and cognitive features, Abeta immunization resulted in a significant clearance of amyloid deposits, with remaining tau and synuclein pathological features in the brain.

Regardless, simply through the demonstrated clearance of amyloid in human patients this is a big step forward for the field.

Previously, other researchers reported that ApoE4 seemed to reduce the clearance of amyloid - β, the protein that clumps together to form the hallmark plaques of AD, from the brain in a mouse model.

One 2013 study showed that the extracellular space in a mouse's brain expands by 60 percent during sleep, and clearance of amyloid plaque (one protein implicated in Alzheimer's) spikes.

Not exact matches

Compared with control groups, the mice that were given oleocanthal showed significantly enhanced clearance and degradation of the beta - amyloid peptides.

The researchers conducted a series of experiments to see if they could replicate the phenomenon of amyloid beta clearance absent brain inflammation.

«In the sporadic form of the disease, we think the problem isn't necessarily with the generation of amyloid - beta, but possibly with its clearance.»

These new findings shift the emphasis to clearance of beta - amyloid.

In the new study, they measured beta - amyloid production and clearance rates in 12 patients with late - onset Alzheimer's and 12 age - matched volunteers free of the disease.

However, the clearance of beta - amyloid was about 30 % slower in those with Alzheimer's disease than in cognitively normal people.

SIRT1, in turn, was thought to reduce the accumulation of amyloid - β by activating another protein — a possible mechanism behind the reduced amyloid - β clearance observed in AD.

«This study is significant in that it reports the first measurement of beta - amyloid production and clearance in Alzheimer's,» says Dr. Marcelle Morrison - Bogorad, director of the Division of Neuroscience at NIH's National Institute on Aging (NIA).

Other theories and lines of research have begun to prosper due to the lack of tangible human results for anti-amyloid immunotherapies, in particular that neurofibrillary tangles of misfolded tau protein are just as much a target for clearance as is amyloid - β, and that perhaps it is time to focus on the decline of known clearance mechanisms rather than the amyloid itself.

Still, over the past couple of years, one of the latest entries to the class of anti-amyloid immunotherapies has lived up to some of the promise first seen in animal studies of amyloid clearance.

However, the new inhibitory neurons did not affect amyloid beta levels, suggesting that the cognitive enhancement did not occur as a result of amyloid clearance, and amyloid did not impair the integration of the transplant.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β Sci Transl Med, 4:147 ra111

The study suggests that «a slow - gamma deficit might be part of this [Alzheimer's disease] pathogenesis [and that] manipulating slow - gamma activity... could be a new way to suppress amyloid - β production and increase amyloid - β clearance,» Huang added.

We can hope that as the first effective therapies make it into the clinic, most likely for the clearance of forms of amyloid, there will be a growing enthusiasm for work on ways to remove other types of metabolic waste.

Researchers have shown that clearance of the substance amyloid - beta that forms plaques is impaired in individuals with Alzheimer's.

There was a significant difference of the average clearance rate for amyloid - beta between the 12 early Alzheimer's individuals and the 12 normal individuals.

Amyloid - beta was produced at the same average rate by both groups, but in the Alzheimer's group there was an average drop in the clearance rates of about 30 %.

Rats undergoing natural sleep or sleep induced by anesthesia increased their brain's interstitial spaces by 60 %.6 This leads to significant exchanges between CSF and interstitial fluid that result in increased rates of beta - amyloid clearance during sleep.

The peripheral sink Aβ hypothesis indicates that the peripheral clearance of Aβ and its regulation by dietary phytosterols is of substantial interest since it may delay hypercholesterolemia and the early onset of amyloid plaque development.