Sentences with phrase «cleavage of amyloid precursor protein»

The main constituents of extracellular amyloid plaque, amyloid β40, 42, is produced by the cleavage of amyloid precursor protein (APP).»

Aβ results from the normal cleavage of amyloid precursor protein (APP), but its accumulation and aggregation into plaques represents the quintessential feature of AD.27 Aβ is found in orders of magnitude greater in AD brains than in healthy brains.28 This fact is noteworthy because lower concentrations of Aβ tend to stay soluble; higher concentrations form plaques more readily.29

Amyloid beta (Aβ) is a small peptide molecule generated from cleavage of amyloid precursor protein (APP).

Specifically, that aggregates of A-beta peptides, which are formed following cleavage of the Amyloid Precursor Protein (APP), instigate a series of events that leads to neurodegeneration and, eventually, AD.

Exploiting this compartmentalization, the team developed an endosomally - targeted β - secretase inhibitor that specifically blocked cleavage of amyloid precursor protein but not non-amyloid proteins.

Not exact matches

Other work addresses mechanisms for decreasing amyloid beta biosynthesis by enhancing cleavage of its precursor protein by the alpha - secretase enzyme.

Proteolytic cleavage of amyloid - β - protein precursor (AβPP) by β - and γ - secretases results in production of the amyloid - β peptide (Aβ) that accumulates in the brains of sufferers of Alzheimer's disease (AD).

The amyloid - β protein precursor (AβPP) is cleaved by a transmembrane protease termed β - site AβPP cleavage enzyme (BACE1), which is being explored as a target for therapy and prevention of Alzheimer's disease (AD).