Sentences with phrase «clinical activities in»

He / she is responsible for administrative, office and clinical activities in above areas.

The downside is that Novavax desperately needs fresh sources of capital soon to advance its clinical activities in RSV and flu, and there's also no guarantee either of these product candidates will become commercially available.

Professor Josep Tabernero, a member of the scientific committee for the EORTC - NCI - AACR Symposium and head of the medical oncology department at Vall d'Hebron University Hospital and director of the Vall d'Hebron Institute of Oncology, Barcelona, Spain, commented: «These are encouraging results, which show that galeterone has significant clinical activity in men with castration - resistant prostate cancer that fails to respond to other drugs.

The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation, according to results from a phase II clinical study.

Venetoclax has durable clinical activity in patients with relapsed / refractory chronic lymphocytic leukemia whose disease progressed during or after ibrutinib therapy.

Early phase trials with anti-PD-L1 and anti-PD-1 antibodies have shown clinical activity in RCC and early biomarker assessment suggests PD - L1 tumor expression may influence response.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Examples of forward - looking statements in this news release include statements regarding the effectiveness of the Company's products, the potential outcome of clinical studies, the future success of development activities and the future growth and operating and financial performance of the Company.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

As for Immunovaccine's DPX - RSV, «development is advancing in the pipeline of a few firms, so we will be watching closely for Immunovaccine to advance DPX - RSV clinical activities imminently,» Loe said.

Clinical testing in human subjects shows that a 50 mg serving of Dermaval ™ inhibits glucose - induced elastase activity in young healthy subjects.

While acknowledging that the [Canadian] study «highlighted a general misinterpretation that an injury described as a concussion is less severe than one described as mTBI,» and that it may result in a premature return to school and activity,» the American Academy of Pediatrics» 2010 clinical report on sports - related concussion in children and teens3 continues to refer to the injury as concussion.

Joan Wenters, Ph.D., a clinical and developmental psychologist at Children's Hospital in Oakland, California, suggests planning one major activity outside the home — going to the movies, the bowling alley, an ice skating or roller skating rink, or a swimming pool.

In talking with past coaches and seeing children in my clinical practice, sports have become a specialization for older kids, and one of the many harried activities for younger oneIn talking with past coaches and seeing children in my clinical practice, sports have become a specialization for older kids, and one of the many harried activities for younger onein my clinical practice, sports have become a specialization for older kids, and one of the many harried activities for younger ones.

This book covers key aspects of hydration and fluid imbalances in athletes of different age groups, sport activities and demands and clinical risk conditions; and it is written by recognized experts in their respective research areas including Professors Michael Bergeron, Ron Maughan and Louise Burke.

«Family time doing household activities is important,» says Joan Wenters, clinical and developmental psychologist at Children's Hospital in Oakland, California.

Clinical experiences include learning in a variety of clinical settings and exposures to a wide range of actClinical experiences include learning in a variety of clinical settings and exposures to a wide range of actclinical settings and exposures to a wide range of activities.

Her professional activities as a clinical child psychiatrist have involved combining research activities with clinical work in various projects both in primary care and mental health services.

Her professional activities as a clinical child psychiatrist have involved developing child mental health assessment methods and combining research activities with child mental health service development and clinical work in various projects both in primary care and mental health services.

«Clinical interviews effective in predicting postpartum depression: Questions regarding work activities especially revealing.»

The award recognizes excellence in school nursing leadership; the winner is selected based on criteria including: clinical practice leadership, administrative leadership, professional development, professional advocacy activity, community involvement and research.

Researchers at the NYU Langone Concussion Center reviewed studies that involved athletes who sustained a concussion during sporting activities and found the vision test, known as the King - Devick test, was 86 percent sensitive in detecting whether a concussion had occurred, as confirmed by clinical diagnosis.

«Of all activities, reading printed books appears to be most relaxing,» clinical psychologist Michael Gradisar said in an interview in Parents magazine.

October is «Breast Cancer Awareness Month» and the activity was part of a concerted effort to promote breast health cognizance in the community and raise funds to provide free clinical breast exams, digital mammography, screening, support and education to women in Rockland County without insurance or who are underinsured.

In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitIn this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitin which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitin high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activitin preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.

As director of the United Kingdom Human Tissue Bank, Samantha Orr manages staff and takes part in clinical and research liaison activities.

«These results also provide a rationale to explore the clinical activity of an OX40 agonist antibody in combination with GSK2636771 in cancer patients with PTEN loss tumors.»

In a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severitIn a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severitin the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severitin these patients is way too active, and the higher its activity, the worse the disease severity.

Weight loss surgery can curb alterations in brain activity associated with obesity and improve cognitive function involved in planning, strategizing and organizing, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Success with these models led to a small phase I clinical trial in which an individual's good bacteria with antimicrobial activity was grown, formulated in a skin cream and applied once to the forearm of the eczema patient infected by S. aureus.

Its altered form moves to the nucleus, where it increases the activity of a gene involved in metastasis (The Journal of Clinical Investigation, DOI: 10.1172 / JCI40433).

Although more work is needed to examine whether those findings are relevant for people, «they suggest that clinical trials testing treatments that increase brain activity, such as deep brain stimulation, should be monitored carefully in people with neurodegenerative diseases,» said Dr. Duff.

The findings, which are published in the journal Clinical Science, show that severe allergic lung inflammation was significantly reduced in the mice when the activity of the pro-inflammatory molecules interleukin (IL)-17 A and IL - 17F was prevented using specific antibodies.

The researchers believe that future research could focus on specific aspects of the self - expanding activities that produce this effect, as well as test the use of self - expansion activities in clinical interventions for smoking cessation.

«Some clinical models suggest that saturated fat might interfere with activity in the the part of the brain that lets us know we're full, in addition to a few studies in people that suggest a diet high in saturated fat interferes with satiety.

«It's become clear that many of the other cannabinoids have potential therapeutic activity, but it's still too early to tell whether that's going to translate into clinical trial data or not,» said Mark Ware from McGill University Health Centre in Montreal, Canada.

There is «strongly accumulating evidence that it is possible in many cases to increase brain activity [long] after severe injury,» Schiff said, but «there is essentially no infrastructure to have clinical follow - up» or even «larger investigative studies.»

In a report that appears online in the journal Nature ¸ Dr. Arthur Beaudet, professor of molecular and human genetics at Baylor College of Medicine and a clinical geneticist at Texas Children's Hospital, and colleagues answer the question: «Can we turn on the activity of the paternal gene?&raquIn a report that appears online in the journal Nature ¸ Dr. Arthur Beaudet, professor of molecular and human genetics at Baylor College of Medicine and a clinical geneticist at Texas Children's Hospital, and colleagues answer the question: «Can we turn on the activity of the paternal gene?&raquin the journal Nature ¸ Dr. Arthur Beaudet, professor of molecular and human genetics at Baylor College of Medicine and a clinical geneticist at Texas Children's Hospital, and colleagues answer the question: «Can we turn on the activity of the paternal gene?»

This information might assist clinicians in choosing clinical treatment, and help researchers develop effective strategies for coping with the negative effects of weather - related effects on cognition that impact independence, education, employment and activities of daily living.»

And this life - tracking craze has produced something that many clinical researchers covet: a deluge of intimate data about individuals» moment - to - moment behavior, and the chance to influence that behavior in real time, through activities built into an app or strategically timed alerts and messages.

«By offering the distinct advantage of subcellular resolution and avoiding the undesirable influence of fluorescent dyes, we believe our technique can complement FDG in clinical PET imaging for visualizing glucose uptake activity at the cellular level,» says the lead author Fanghao Hu, a Ph.D. candidate in chemistry.

In the case of IPF, the researchers now want to establish a drug screening assay and begin clinical trials with an FKBP10 inhibitor, an agent to inhibit the production or activity of the FKBP10 protein.

Older men with low libido and low testosterone levels showed more interest in sex and engaged in more sexual activity when they underwent testosterone therapy, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Recent estimates from the Centers for Disease Control and Prevention (CDC) indicate that around 10 percent of adults in the United States currently suffer from clinical depression — depression that consists of symptoms such as disruptions in eating, sleeping, and concentration patterns, lack of interest in daily activities, and consistently feeling like a failure.

Many researchers are also hopeful about clinical trials under way with drugs that block certain receptors for glutamate, the main neurotransmitter in the brain that excites neural activity.

«Until now, it was quite challenging to accurately measure the electrical patterns of stomach activity in a continuous manner, outside of a clinical setting.

«This graphene system is able to detect the level of activity of an interfaced cell,» says Vikas Berry, associate professor and head of chemical engineering at UIC, who led the research along with Ankit Mehta, assistant professor of clinical neurosurgery in the UIC College of Medicine.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioIn a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioin a mouse model of the neurodegenerative condition.

Clinical response to the therapies was defined as a drop in DAS28 - ESR (disease activity score) of 1.2 units between the baseline and at three months.

It could also help distinguish healthy and unhealthy brain activity in young babies, a vitally important aspect of clinical trials for drugs aimed at protecting the brain from infection.