Sentences with phrase «clinical applications in»

Just as there is a gap between controlled interventions and clinical applications in child and adolescent psychotherapy, 15,16 the transition from efficacious parent support approaches to effective community program practice needs to be carefully implemented and tracked.17

Unfortunately, however, Fgf21 has also been shown to cause bone loss, which will need to be overcome if this hormone is to be used for clinical applications in obesity138.

Importantly, because it is already approved for clinical use, amiodarone HCL may have clinical applications in cell replacement therapies by selectively removing only the unwanted undifferentiated NSCs during the pre-transplant period.

In the current analysis, we did not observe a disadvantage for clinical applications in study sections whose assignments included 25 % or fewer clinical applications.

Alternatively, review of clinical applications in study sections reviewing predominantly laboratory - oriented research may have been less of a problem in 2002 than in 1994.

These findings support a path to improving clinical applications in restoring human vision lost to degenerative eye diseases.

The research has potential clinical applications in inflammatory disorders such as Crohn's disease and pouchitis, which can be a complication of Crohn's or ulcerative colitis, Camilleri says.

In future studies, Sulchek and his team plan to test this approach and scale up the technology with clinical applications in mind.

A HD pig could be an opportunity to test if CRISPR - Cas9 gene editing can work in larger animals before clinical applications in humans.

As such, it provides a means of moving organoids from basic research to actual pharmaceutical and clinical applications in the future.

«This alternative source of Leydig cells will be of great significance for basic research and provides the attractive prospect of clinical application in the field of regenerative medicine.»

While the findings have only been seen in animals models so far, Zeng said that successful translation of the regimen into clinical application in humans may represent a novel approach that allows strong anti-cancer effects without causing GVHD.

In addition, our studies provide a specific population of human astrocytes that appears to be particularly suitable for further development towards clinical application in treating the traumatically injured or diseased human central nervous system.

Not exact matches

In particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDIn particular, the complaint alleges that throughout the Class Period, defendants made materially false and / or misleading statements and / or failed to disclose that (1) the trials for GED - 0301 suffered from fatal design defects, such that GED - 0301 had failed to demonstrate meaningful clinical efficacy; (2) the growth of Otezla sales had dramatically slowed during Celgene's third fiscal quarter of 2017; and (3) the clinical and nonclinical pharmacology data in Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDin Celgene's new drug application («NDA») for Ozanimod were insufficient to permit a complete review by the FDA, which resulted in the FDA issuing a refusal to file letter to Celgene regarding the NDin the FDA issuing a refusal to file letter to Celgene regarding the NDA.

The combo proved non-inferior to competing HIV medicines in a slew of late - stage clinical trials, and Gilead is expected to file a new drug application with the FDA soon.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

At the dawn of the digital health revolution, some argued that fitness trackers were being marketed as a way for companies with long - range ambitions to produce devices with clinical applications to get to revenue in the short - term.

MobiHealthNews recently reported that more and more consumer - facing digital health companies are signaling a shift in focus away from unregulated fitness and wellness space and towards clinical applications for their technologies.

Additional human clinical research suggests that Suntheanine may have application in diminishing normal symptoms of premenstrual syndrome (PMS), improving learning performance, heightening mental acuity, promoting concentration, reducing negative side effects of caffeine and supporting the immune system.

Meanwhile, Eisai will conduct clinical trials for seeking regulatory approval, and make the applications in Asia.

In this randomized, double - blind clinical trial, virgin coconut oil was the clear winner: «among pediatric patients with mild to moderate AD, topical application of virgin coconut oil for eight weeks was superior to that of mineral oil based on clinical (SCORAD) and instrumental (TEWL, skin capacitance) assessments.»

Read on for technical insights and market information on key usage applications and opportunities for these dairy ingredients in three growing categories that are highly dependent on high - quality protein sources: sports nutrition, infant and early child nutrition and clinical nutrition.

In her 24 years of clinical work with children, adolescents, and young adults, she has emphasized the critical importance of integrating neuropsychological assessment findings to the application of accommodations to the classroom and home environments in a «user - friendly» manneIn her 24 years of clinical work with children, adolescents, and young adults, she has emphasized the critical importance of integrating neuropsychological assessment findings to the application of accommodations to the classroom and home environments in a «user - friendly» mannein a «user - friendly» manner.

In her latest book, The Developmental Science of Early Childhood: Clinical Applications of Infant Mental Health Concepts from Infancy Through Adolescence, she describes how larger forces in the family and in the child's biology can affect behavior and how to understand a child's deep storIn her latest book, The Developmental Science of Early Childhood: Clinical Applications of Infant Mental Health Concepts from Infancy Through Adolescence, she describes how larger forces in the family and in the child's biology can affect behavior and how to understand a child's deep storin the family and in the child's biology can affect behavior and how to understand a child's deep storin the child's biology can affect behavior and how to understand a child's deep story.

As genetic technologies advance both in terms of speed and reducing costs, more and more clinical applications are seen in the NHS.

«Our studies provide promising results in mice, which merit further investigation, such as adjusting the formulation, dose and delivery route of MAOA inhibitors, prior to ultimate clinical application.»

Virtual reality has emerged into popular culture with an ever - widening array of applications including clinical use in a pediatric healthcare center.

I promptly chose to go into clinical pharmacy — the most exciting application of pharmaceutical knowledge — helping patients in the hospital maximize the effects of the drugs they are prescribed while minimizing the potential side effects.

Three of these themes represent the key scientific steps in moving stem cells from the laboratory into the clinic — the bioengineering and biology of stem cells, and the clinical applications of that research.

Another field that might appeal to your desire to work in a role with clinical applications is that of clinical trials.

He has submitted his first clinical - trial application to the US Food and Drug Administration, and hopes to begin testing the rice - derived HSA in humans within the next two years.

The new material, described online 25 April in Science by synthetic chemist Andreas Lendlein of mnemoScience GmbH in Aachen, Germany, and biomedical engineer Robert Langer of the Massachusetts Institute of Technology, is composed of two polymers, each already used separately in clinical applications such as drug delivery.

I also want to be involved in something that has obvious clinical applications, rather than basic science.Do you think industry is a better bet than academia?

«There are certainly challenges to overcome for clinical application of this kind of immunotherapy, but the newly published data are an important milestone in immunotherapy targeting solid tumors that have eluded other treatments.»

But in order to find the right «fit» for you, we need to consider your wish to work more closely with people, both in terms of personal contact and clinical application.

And he reaches a sobering conclusion: «Hierarchies are a poor basis for the application of evidence in clinical practice.

There already has been great effort to elucidate the mechanisms of gene expression regulation, but it will be important to continue research to fully realize the potential of these epigenetic therapies and their applications in clinical settings.

By enabling the observation of cilia beating frequency, the experimental model described in this work provides more realism for clinical applications.

This work represents a first step towards the use of graphene in research as well as clinical neural devices, showing that graphene - based technologies can deliver the high resolution and high SNR needed for these applications.

«This collaborative multi-disciplinary effort identifies «mitochondrial genome integrity» as a vital readout in assessing the proficiency of patient - derived regenerative products destined for clinical applications,» adds study co-author Andre Terzic, M.D., Ph.D., Director, Mayo Clinic Center for Regenerative Medicine.

«For several years the potential for the use of gene expression data in research and clinical applications has been underappreciated due to the inconsistency of the data coming from the various types of equipment.

In the United States, such clinical trials are effectively banned by a rule that prevents the Food and Drug Administration from reviewing applications for any procedure that would introduce heritable changes in human embryoIn the United States, such clinical trials are effectively banned by a rule that prevents the Food and Drug Administration from reviewing applications for any procedure that would introduce heritable changes in human embryoin human embryos.

The article went on to proclaim this «the first clinical application of iPS cells» and said the results were being presented at a conference in New York.

The contest involves writing a 500 - word essay in English, or 1,500 characters in Japanese, about translational medicine, which is a relatively new scientific field where human health is promoted by facilitating communication among those dedicated to basic and clinical research and its application.

A new application of a common clinical test, the positron emission tomography (PET) scan, seems to be able to differentiate between minimally conscious brains and those in a vegetative state.

Bacteria of the species Streptomyces produce approximately 70 per cent of all antibiotics of natural origin used in clinical applications.

Especially in clinical application during treatments of severe infections e.g. a sepsis time is a crucial factor.

It could also be relevant to clinical applications — it treats sequence uniqueness as a high priority and thus minimises the risk of potentially unwanted gene modifications, which must be avoided at all costs in gene therapy,» says Graf.

And because the field taps into basic and social neurosciences and may have applications in clinical disorders such as autism, Blanke expects research funds in the area to increase.