Sentences with phrase «clinical benefit»

Evidence based exercise — clinical benefits of high intensity interval training.

My research brings these elements together with the intention of achieving greater clinical benefit.

Previous attempts to treat negative symptoms have employed drugs, hormones, and brain stimulation, but none have provided the desired clinical benefit.

So with a lack of definitive clinical benefit, and a possibility of adverse effects, why use fish oil supplements at all?

We tentatively conclude that cognitive behaviour therapy, used as an adjunct treatment for chronic schizophrenia, can result in clinical benefits in the short term.

«We now hope to design larger clinical studies to treat patients» tumors harboring these novel genomic aberrations to further explore the precise extent of clinical benefit for patients with primary or advanced cholangiocarcinoma.»

According to the researchers, «the combination of an antibody that inhibits PD - L1 and PD - 1 [programmed death 1] interactions with a targeted antiangiogenic agent might take advantage of complementary mechanisms of action to provide clinical benefit in patients with advanced renal cell carcinoma that exceeds the effects of the respective drugs alone, without increasing associated toxicity.»

The second potential clinical benefit of impact monitoring systems stems not from the idea of monitoring impacts for the presence of an acute injury - generating hit, but from the potential advantage of accurately cataloguing the number of hits and post-impact head acceleration being experienced by an athlete over time.

The experimental drug selumetinib is the first targeted therapy to demonstrate significant clinical benefit for patients with metastatic uveal melanoma, according to new Memorial Sloan - Kettering Cancer Center research presented on Saturday, June 1, at the 49th annual meeting of the American Society of Clinical Oncology (ASCO).

«We are hopeful these exciting preclinical results will translate into clinical benefit for patients.

«Future patient - centered quality measures should focus on clinical benefit rather than age to ensure that patients who are likely to benefit from screening receive it, regardless of age, and that those who are likely to incur harm are spared unnecessary and costly care,» says senior study author Eve Kerr, M.D., M.P.H., director of VA - CCMR and professor of internal medicine at the U-M Health System.

Adding metformin to a combination of everolimus plus letrozole for women with advanced or recurrent endometrioid endometrial cancer might offer clinical benefits.

«This is the first published study showing clear clinical benefit of a treatment for refractory cough.

«Rucaparib shows clinical benefit in pancreatic cancer patients with BRCA mutation: Results suggest a potential — and much - needed — treatment option for some pancreatic cancer patients.»

In melanoma, an increase in overall mutational and neoantigen load — novel tumor - specific antigens that can be recognized by the immune system — was associated with clinical benefit from checkpoint blockade.

According to the researchers continued surveillance of HPV vaccination is necessary to identify clinical benefits, particularly given the low rate of vaccine uptake and completion and vaccination of many young women after sexual debut.

to date no solid evidence exists to be able to say that adding DHA to infant formula will have important clinical benefits.

Total elimination of ALL lead from the body is not necessary (or maybe even possible) to see clinical benefits, however, preventively a strong case can be made for the greatest possible reduction of body burden of toxic metals, given the documented adverse health effects.

Dr Claire Smith, Consultant Neonatologist at the Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, added: «This study has the potential to provide real clinical benefits in the future.

Under the terms of the FDA's accelerated approval, Sarepta must conduct a clinical trial of eteplirsen to confirm clinical benefit.

«Immune checkpoint inhibitors, including PD - 1 and PD - L1 inhibitors, have provided meaningful clinical benefits for patients with cancer; however, novel immunotherapy combination treatments are needed to improve efficacy with limited additive toxicity,» said Aung Naing, MD, FACP, associate professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston.

Unlike targeted therapy and conventional chemotherapy for most malignancies, immunotherapy has the advantage of providing long - term clinical benefit in some patients.

The phase II part, with an expanded cohort of up to 120 patients in a 1:1 randomization to pembrolizumab with or without PV - 10, will assess clinical benefit (PFS).

If the ongoing trial in FL patients produces a sufficiently robust clinical benefit for patients, we may pursue FL as the first indication for which we intend to seek regulatory approval for G100.

To evaluate whether family intervention reduces the subjective burden of care in carers of patients with Alzheimer's disease and produces clinical benefits in the patients.

While the scientific community is actually divided on the actual clinical benefits of providing dogs with joint health supplements such as glucosamine, chondroitin sulfate, and methyl sulfonyl methane or MSM, many dog owners are nonetheless providing these supplements to their dogs with dysplastic hip joints.

Each approach presents great potential, but also has its own set of limitations and it is crucial to pursue efforts in all avenues of stem cell research in order to achieve clinical benefit from this technology as quickly as possible.

«The US spends $ 90bn on cancer therapies annually and about 75 % of that fails to provide the intended clinical benefit of prolonged patient survival.»

But such outcomes are rare in healthy individuals anyway, so the risk reduction actually translated to a small clinical benefit — reducing the overall risk from 4.04 percent to 3.27 percent per year, a difference of 0.77 percent.

Only one product had a 1 - to - 1 ratio, which some research suggests is associated with fewer side effects and improved clinical benefit compared with higher ratios of THC to CBD.

He had reason to think so, because clinical benefits had been seen in cancer patients who received ipilimumab along with cancer vaccines that pumped out GM - CSF.

«This is a very promising breakthrough, potentially offering significant clinical benefits including to the field of cancer imaging.

«Our research shows that radiosurgery in this patient cohort does reduce the incidence of local recurrence, although the findings for overall brain control, overall survival and time until whole brain radiation therapy limit our ability to conclude an obvious clinical benefit,» said Dr. Mahajan.

One study reported clinical benefits using gene therapy to regenerate joint cartilage in patients with rheumatoid arthritis.

Researchers led by Van Allen and Choueiri sought an explanation for why some patients with a form of metastatic kidney cancer called clear cell renal cell cancer (ccRCC) gain clinical benefit — sometimes durable — from treatment with immune checkpoint inhibitors that block the PD - 1 checkpoint, while other patients don't.

«With this in mind, it's important to examine the relationship between clinical benefit and possible side effects in consultation with the doctor treating the patient,» says Locher.

Without industry following up on their discoveries, they say, «scientists working in stem - cell medicine will not be able to deliver clinical benefits.

The effectiveness of the concomitant approach demonstrated in this definitive study also indicates the importance of future clinical studies that seek greater clinical benefit through the study of multi-targeted approaches in earlier disease settings.»

Both drugs have shown promising activity as single - agents in a variety of clinical studies in different tumor types, and it has been hypothesized that combining these two drugs may result in added clinical benefit.

«Patients will only get the full clinical benefit of their medications if they take them, and our study found that patients are more likely to take generic statins than brand - name versions, which have a higher associated cost.»

According to the researchers, more research is needed to determine if off - label use of antipsychotic medications yields substantial clinical benefit and to identify how doctors decide to prescribe these drugs for non-FDA approved conditions.

He further notes that there is ``... significant discordance between preclinical findings and clinical results» and ``... inefficient partnerships between academia and industry,» two challenges that must be addressed if academic research is to yield maximum clinical benefit and attain the ultimate goal of saving patients» lives.

«By these standards, improvements in a sense of social connectedness may have clinical benefits comparable to lifestyle modifications,» the authors wrote.