Sentences with phrase «clinical effectiveness trials»

Not exact matches

Cost of realizing the effectiveness of excipients through clinical trials is substantial, which constrains the development of novel excipients, thereby restraining investments in research & development.

Many experts throughout history, including Hippocrates, considered and prescribed phytochemicals as medications and clinical trials have proven the effectiveness of many in enhancing health states.

Because the trial found no differences in the effect of type of care on any primary clinical outcome, the economic analysis compares only the costs of care rather than their cost - effectiveness.

The clinical effectiveness of different parenting programmes for children with conduct problems: a systematic review of randomised controlled trials

The Nurture Science Program is conducting randomized clinical trials to test the effectiveness of Family Nurture Intervention in the neonatal intensive care unit (NICU).

Effectiveness of home - based peer counselling to promote breastfeeding in the northeast of Brazil: a randomised clinical trial

A randomised controlled trial to evaluate the clinical and cost effectiveness of breastfeeding peer support groups in improving breastfeeding initiation, duration and satisfaction

A phase I clinical trial for a Zika vaccine which began in August 2016 in partnership with the Wistar Institute and Inovio / GeneOne Pharmaceuticals aims to discover the safety and effectiveness of a DNA vaccine for Zika.

But given its low cost, availability and safety history further study in a clinical trial to test its effectiveness against Zika virus in humans is merited.»

This may explain why thymidine showed limited effectiveness as a single agent in clinical trials.

Published in the journal Molecular Cancer Therapeutics, the study also found that use of a second inhibitor might improve the effectiveness of these drugs by possibly preventing resistance, and it recommends that clinical trials should be designed to include a second inhibitor.

According to Dunbar, the next logical step would be to take evinacumab into larger clinical trials to study its safety, effectiveness, and optimal dosing.

As promising new therapies such as those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectiveness.

Carl E. Clarke, M.D., of the University of Birmingham, England, and coauthors conducted a large clinical trial to evaluate the effectiveness of PT and OT in 762 patients with mild to moderate PD who were recruited from 38 sites across the United Kingdom.

Their results, published this week in the journal Biomedical Optics Express, from The Optical Society (OSA), may yield a cheaper and less invasive initial screening test for colon cancer that could complement colonoscopy, though further clinical trials will need to demonstrate the safety and effectiveness of the blood test before it is routinely used.

They are launching a clinical trial to evaluate the safety of their approach and gauge its effectiveness in patients with lymphoma, a cancer of the lymphatic system.

The group's models could also help interpret data from future clinical trials that evaluate the effectiveness of booster shots in schoolchildren, «as well as predict the potential impact of new vaccination strategies,» he said.

Designed to test the safety and effectiveness of this new approach, the clinical trial was led by principal investigator Richard Andersen, the James G. Boswell Professor of Neuroscience at Caltech, neurosurgeon Charles Y. Liu, professor of neurological surgery, neurology, and biomedical engineering at USC, and neurologist Mindy Aisen, chief medical officer at Rancho Los Amigos.

In the next stage of this research involving clinical trials, the scientists intend to test the effectiveness of these reversible monoamine oxidase A inhibitors in the treatment of postpartum depression.

Currently, clinical trials are under way to test the effectiveness of mechanically pumping large amounts of these proteins into the affected area of patients» brains on a continuing basis.

Consequently, they hope that their results will «motivate the incorporation of assays measuring ex-vivo T - cell function into ongoing and planned clinical trials of HDAC inhibitors, and that immunosuppression will be considered as a potential factor limiting the effectiveness of any observed outcomes.»

With that idea in mind, Karmali is leading an innovative Phase II clinical trial evaluating the effectiveness of combining the diabetes medication metformin with standard chemotherapy to treat patients with diffuse large B - cell lymphoma.

Omer, Tzannou and their colleagues conducted a clinical trial to determine the safety and effectiveness of pre-prepared virus - specific cells to treat five viral infections simultaneously in patients who had received a hematopoietic stem cells transplant.

Many patients and physicians assume that the safety and effectiveness of newly approved drugs is well understood by the federal Food and Drug Administration (FDA)-- but a new study by researchers at Yale School of Medicine shows that the clinical trials used by the FDA to approve new drugs between 2005 and 2012 vary widely in their thoroughness.

It showed effectiveness against liver cancer in a phase II clinical trial and will move into a phase III trial later this year, David Kirn, an oncologist and the company's president and chief executive officer, said at a recent meeting of the American Society for Gene & Cell Therapy in Washington, D.C..

«New report calls into question effectiveness of pregnancy anti-nausea drug: Researchers reanalyze clinical trial results reported in 2010.»

«This comparative effectiveness clinical trial provides two new treatments for the 50 percent of adults with autism who have average or above intelligence and formal language,» said Minshew, adding that it's now critical that both new treatments be disseminated in the community.

The phase I and phase I / II trials aimed to measure the safety of adding HCQ to either chemotherapy, radiation therapy or targeted therapies, its effectiveness at inhibiting autophagy, and the potential clinical benefit of HCQ combination therapies.

More recently, HCQ has shown promise in treating pancreatic cancer patients in ongoing clinical trials; however, its tolerability and effectiveness to stop autophagy in humans with other cancers has not been shown before.

The controversy came to a head in March when the National Institutes of Health issued a notice of a competition soliciting participation in a large - scale clinical trial to evaluate the effectiveness of fetal surgery as a treatment for spina bifida.

Dr de Moor said that provided the safety and effectiveness of the compound could be proven, clinical trials could begin within six to ten years.

The researchers are now running a larger, double - blind, randomized clinical trial of the drug in 152 patients, planning to evaluate its effectiveness next October.

«While dozens of clinical trials have demonstrated the effectiveness of collaborative care for treating depression in primary care, comparatively few have addressed anxiety, despite their similar prevalence and adverse impact on health - related quality of life and excess utilization of health services,» said Bruce L. Rollman, M.D., M.P.H., professor of medicine and director of Pitt's Center for Behavioral Health and Smart Technology.

The key change is the creation of a new health research regulatory agency, known as the National Institute for Health Research (NIHR), to streamline regulation and improve the cost effectiveness of clinical trials.

«Given the effectiveness of inosine in promoting cortical plasticity, axonal sprouting, and dendritic branching, the present evidence of efficacy after cortical injury in a non-human primate, combined with a long history of safe use, indicates a need for clinical trials with inosine after cortical injury and spinal cord injury,» noted Dr. Moore.

They would like to conduct a much larger clinical trial to determine its effectiveness.

Ebell's next plan is to perform a randomized clinical trial to test the effectiveness of the point score system, including the use of a CRP test, in clinical practice.

Offsetting any such savings, according to CSDD, are higher costs due to the increased complexity of clinical trials, a greater focus on chronic and degenerative diseases, and tests for insurers seeking comparative drug effectiveness data.

Its effectiveness in several clinical trials led the U.S. Food and Drug Administration to approve preventive use of ARVs in 2012.

Overall, the investigators found that foods, nutrients, dietary patterns or supplement use assessed before the start of the clinical trial had no measurable influence on the effectiveness of a multivitamin on CVD risk in middle - aged and older men.

The researchers plan to carry out phase III randomized controlled clinical trials to determine the actual rate of effectiveness by comparing those treated with the ketogenic diet to a group tube - fed a normal, nonketogenic diet.

Researchers say larger, longer clinical trials are needed to prove the drug's safety and effectiveness before it can be approved for sale.

The next stage will be a full clinical trial to test the effectiveness of ebselen as a treatment.

Researchers analysed more than 3,000 people involved in a clinical trial assessing the effectiveness of alteplase as a stroke treatment.

Adam R. Glassman, M.S., of the Jaeb Center for Health Research, Tampa, Fla., and colleagues examined the incremental cost - effectiveness ratios (ICERs) of aflibercept, bevacizumab, and ranibizumab for the treatment of DME with an analysis of efficacy, safety, and resource utilization data at 1 - year follow - up from the Diabetic Retinopathy Clinical Research (DRCR) Network Comparative Effectieffectiveness ratios (ICERs) of aflibercept, bevacizumab, and ranibizumab for the treatment of DME with an analysis of efficacy, safety, and resource utilization data at 1 - year follow - up from the Diabetic Retinopathy Clinical Research (DRCR) Network Comparative EffectivenessEffectiveness Trial.

However, in this Phase II clinical trial, designed to prospectively evaluate the safety and effectiveness of ACHT for patients with HIV - related lymphoma, researchers discovered that this population had no greater likelihood of developing these complications compared to those without the virus.

The study, «A Multi-Center Clinical Trial to Evaluate the Effectiveness of Intermittent Hypoxia Therapy in Individuals with Spinal Cord Injury (SCI),» is being conducted by an experienced team of scientists and clinicians at three leading SCI rehabilitation institutions: Shirley Ryan AbilityLab (lead investigator, William Zev Rymer, MD, PhD), Kessler Foundation (Gail Forrest, PhD; Steven Kirshblum, MD), and the University of Miami (Monica A. Perez, PT, PhD).

deCODE has in - licensed a compound, DG031, designed to inhibit FLAP, and the company has designed clinical trials to test its effectiveness in reducing key measures of inflammation and in preventing heart attack.

«Efficacy» is used in clinical trial settings, whereas «effectiveness» is used in real world (not carefully controlled) settings.

These clinical trials are studying the effectiveness and safety of the drug.