Sentences with phrase «clinical effects of cancer»

Not exact matches

Some retrospective studies and preclinical work have indicated that it might also lower a person's risk of cancer, though at least one clinical trial wasn't able to show that it had any protective effect on esophageal cancer.

Although a considerable body of scientific evidence substantiates the positive correlation between curcumin consumption and a reduction in the risk of cancer, the paucity of suitably designed human clinical trials that clearly demonstrate any direct effect of curcumin on cancer markers may prevent Health Canada from approving a cancer risk reduction claim for curcumin within the current regulatory framework.

The thousands of clinical studies that have looked into the effects of diet on cancer point to these factors being most important for cancer risk reduction:

Professor Arnie Purushotham, Cancer Research UK's senior clinical adviser, said: «One of the challenges when treating early stage breast cancer is trying to minimise the side effects that can have a real impact on a woman's life, without affecting the chances of curinCancer Research UK's senior clinical adviser, said: «One of the challenges when treating early stage breast cancer is trying to minimise the side effects that can have a real impact on a woman's life, without affecting the chances of curincancer is trying to minimise the side effects that can have a real impact on a woman's life, without affecting the chances of curing her.

«Our preclinical data suggest that combining low doses of these inhibitors will enhance the clinical effects of both drugs as a potential treatment for patients with AML,» says the senior author, Feyruz V. Rassool, PhD, associate professor of radiation oncology at the University of Maryland School of Medicine (UM SOM) and a researcher at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC).

The team is now calling for a much larger clinical trial, involving one quarter of a million women, to investigate the effect of the screening using HPV testing on cancer rates.

«Since epalrestat is already on the market and has no major adverse side effects, our study provides a proof of principle that it could become a valuable targeted drug for the clinical treatment of basal - like breast cancer,» Dong says.

For example, a clinical trial might determine whether a particular treatment for prostate cancer is safe and effective; a CER study might also consider cost and side effects such as frequency of urinary incontinence.

The program works by connecting computer - generated drug profiles — including mechanisms of action, clinical efficacy, and side effects — with information about how a molecule may interact with human proteins in specific diseases, such as ovarian cancer.

However, clinical evidence supporting the chemopreventive effect of aspirin therapy on liver cancer remains limited.

But this is early laboratory research and the next stage is for clinical trials to confirm whether resveratrol has the same effects in people at high risk of bowel cancer.»

«Randomized Controlled Pilot Trial of Mindfulness - based Stress Reduction for Breast and Colorectal Cancer Survivors: Effects on Cancer - related Cognitive Impairment,» published online in advance of print in the Journal of Cancer Survivorship, is the first randomized clinical trial to evaluate the effects of mindfulness - based stress reduction, known as MBSR, on fatigued breast and colorectal cancer survivors, the majority of whom had been treated with chemothCancer Survivors: Effects on Cancer - related Cognitive Impairment,» published online in advance of print in the Journal of Cancer Survivorship, is the first randomized clinical trial to evaluate the effects of mindfulness - based stress reduction, known as MBSR, on fatigued breast and colorectal cancer survivors, the majority of whom had been treated with chemothCancer - related Cognitive Impairment,» published online in advance of print in the Journal of Cancer Survivorship, is the first randomized clinical trial to evaluate the effects of mindfulness - based stress reduction, known as MBSR, on fatigued breast and colorectal cancer survivors, the majority of whom had been treated with chemothCancer Survivorship, is the first randomized clinical trial to evaluate the effects of mindfulness - based stress reduction, known as MBSR, on fatigued breast and colorectal cancer survivors, the majority of whom had been treated with chemothcancer survivors, the majority of whom had been treated with chemotherapy.

Survivors should be assessed for physical (e.g.: urinary, sexual, bowel) and psychosocial effects of prostate cancer and its treatment; the focus of assessment should be tailored to the type of cancer treatment received and current disease state to trigger appropriate self - management and clinical management strategies for support and therapy.

Syndax Pharmaceuticals, Inc. («Syndax,» the «Company» or «we»)(Nasdaq: SNDX), a clinical stage biopharmaceutical company developing entinostat and SNDX - 6352 in multiple cancer indications, in collaboration with The Wistar Institute and Indiana University Melvin and Bren Simon Cancer Center, today announced the publication of a preclinical report demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (Mcancer indications, in collaboration with The Wistar Institute and Indiana University Melvin and Bren Simon Cancer Center, today announced the publication of a preclinical report demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MCancer Center, today announced the publication of a preclinical report demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

«The results in our study are very similar to those obtained in a large European randomized clinical study (ERSPC) thus confirming the effect of PSA testing on the risk of prostate cancer death.

The article, titled «Entinostat Neutralizes Myeloid Derived Suppressor Cells and Enhances the Antitumor Effect of PD - 1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma,» was published in Clinical Cancer Research and is available online.

The USPSTF based its recommendations on a meta - analysis of 136 clinical trials, observational studies and a systematic review evaluating the effects of supplementation on fracture and cancer risk.

Effect of robotic - assisted vs conventional laparoscopic surgery on risk of conversion to open laparotomy among patients undergoing resection for rectal cancer: the ROLARR randomized clinical trial.

«Clinical trial shows benefit of yoga for side effects of prostate cancer treatment: Twice - weekly yoga led to better physical, sexual, emotional, and social health, study finds.»

Moreover, our previous study found that regular use of aspirin after diagnosis was associated with longer survival among the 15 % to 30 % of patients with colorectal cancer and with a mutation in phosphatidylinositol -4,5-bisphosphate 3 - kinase, catalytic subunit alpha (PIK3CA [NCBI Entrez Gene 5290]-RRB-, one of the PI3K family genes.30 Markedly improved survival associated with aspirin according to PIK3CA status was also found in an analysis within a separate clinical trial cohort.31 Further investigations for the joint effect of these genes would be helpful to better understand the underlying molecular mechanisms of aspirin, NSAIDs, and colorectal cancer.

«There's a great need in cancer patients to be able to quickly and easily assess if a particular treatment is working in order to switch to another if it's not, thus avoiding wasted time, potential side effects and cost,» says Kala Visvanathan, M.D., M.H.S., professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, professor of oncology at the Johns Hopkins University School of Medicine and director of the Clinical Cancer Genetics Program at the Johns Hopkins Kimmel Cancer Ccancer patients to be able to quickly and easily assess if a particular treatment is working in order to switch to another if it's not, thus avoiding wasted time, potential side effects and cost,» says Kala Visvanathan, M.D., M.H.S., professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, professor of oncology at the Johns Hopkins University School of Medicine and director of the Clinical Cancer Genetics Program at the Johns Hopkins Kimmel Cancer CCancer Genetics Program at the Johns Hopkins Kimmel Cancer CCancer Center.

The effect of hepatic impairment on outcomes in phase 1 clinical trials in cancer subjects.

There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.

Her current focus is on developing clinical protocols for the treatment of head and neck and lung cancers with a goal of providing enhanced tumor control, including control of metastases, with minimal effect of quality of life.

Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-cancer effects either as a single agent or in combination with other drugs in treatment of esophageal cancer, B - cell chronic lymphocytic leukemia, endometrial carcinoma, recurrent / metastatic squamous cell carcinoma and most relevantly, previously treated locally advanced or metastatic breast cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).

The American Society of Clinical Oncology released a statement that says even light drinking can raise risks of certain types of cancers, with heavy drinkers experiencing even more extreme effects.

In a clinical study published in 2009 in the Journal of Cancer Science and Therapy, scientists studied far infrared's effects on human cancer cells in vitro and on cancer cells inCancer Science and Therapy, scientists studied far infrared's effects on human cancer cells in vitro and on cancer cells incancer cells in vitro and on cancer cells incancer cells in mice.

27 Studies cited by the 2010 DGAC Report demonstrate varied metabolic responses to lowered dietary saturated fat, with certain subpopulations exhibiting adverse rather than improved health outcomes.3 Two recent comprehensive meta - analyses indicate that saturated fat is not linked to heart disease.28, 29 In fact, in a definitive review of forty - eight clinical trials, with over sixty - five thousand participants, the reduction or modification of dietary fat had no effect on mortality, cardiovascular mortality, heart attacks, stroke, cancer, or diabetes.30 Yet, avoiding saturated fat remains a cornerstone of national dietary guidance.

The U.S. National Institutes of Health counts 135 registered trials of curcumin in the last 15 years, according to the study authors, but not one double - blind, placebo - controlled clinical trial on curcumin can support all of the benefits we've been attributing to it, and when it comes to research that seemed to prove curcumin's effects on pancreatic and colon cancers, Alzheimer's disease, and radiation - induced rashes, it seems that the supposed benefits are all cracked up.

Other publications on cancer chemoprevention include Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials, Chemopreventive effects of natural dietary compounds on cancer development, Organosulfur compounds in cancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selcancer chemoprevention include Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials, Chemopreventive effects of natural dietary compounds on cancer development, Organosulfur compounds in cancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selcancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials, Chemopreventive effects of natural dietary compounds on cancer development, Organosulfur compounds in cancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selcancer development, Organosulfur compounds in cancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selcancer chemoprevention, Cancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selCancer prevention by natural compounds, Cruciferous vegetables and cancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selcancer prevention, Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selcancer risk: epidemiologic evidence and mechanistic basis, Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selcancer protective mechanisms of glucosinolate hydrolysis products and selenium.

A randomized, wait - list controlled clinical trial: The effect of a mindfulness meditation - based stress reduction program on mood and symptoms of stress in cancer outpatients.

As of June 2015, there were 116 clinical trials evaluating the possible anti-disease effect of curcumin in humans, including studies on cancer, gastrointestinal diseases, cognitive disorders, and psychiatric conditions.

(1995) «The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research)» Urol Nefrol (Mosk) Mar - Apr (2): 46 - 7

There is much progress and clinical research required in order to scientifically and medically validate positive clinical effects upon cancer of a ketogenic diet.

Laboratory and clinical studies on ayurvedic herbal preparations and other therapies have shown them to have a range of potentially beneficial effects for preventing and treating certain cancers, treating infectious disease, promoting health, and treating aging.

There is definitely clinical human data demonstrating beneficial effects of various phytonutrients on various cancers; berries for esophageal cancer and flax for prostate cancer come to mind.

In summary, perhaps through glucose «starvation» of tumour cells and by reducing the effect of direct insulin - related actions on cell growth, ketogenic diets show promise as an aid in at least some kind of cancer therapy and is deserving of further and deeper investigation — certainly the evidence justifies setting up clinical trials.

Do the anticancer effects of phytates in a petri dish translate out into clinical studies on cancer prevention and treatment?

Possible Reasons for the Lack of a Protective Effect of Dietary Fiber in Some Trials There is considerable debate and speculation as to why clinical inter - vention trials on the relationship between fiber intake and colon cancer have not shown the expected beneficial effect of Effect of Dietary Fiber in Some Trials There is considerable debate and speculation as to why clinical inter - vention trials on the relationship between fiber intake and colon cancer have not shown the expected beneficial effect of effect of fiber.

Other clinical trials in cancer patients have studied the effects of acupuncture on cancer symptoms and side effects caused by cancer treatment, including weight loss, cough, coughing up blood, fever, anxiety, depression, proctitis, speech problems, blocked esophagus, and hiccups.

374 DIETARY REFERENCE INTAKES and other positive findings, a number of important studies (Fuchs et al., 1999; Giovannucci and Willett, 1994) and three recent clinical interven - tion trials (Alberts et al., 2000; Bonithon - Kopp et al., 2000; Schatzkin et al., 2000) do not support a protective effect of Dietary Fiber intake against colon cancer.

In this capacity he has invested a great deal of time and effort on clinical trials examining the effects of broccoli sprouts (which contain phytochemicals extremely closely related to those found in moringa) in protecting against cancers, COPD, asthma, autism, schizophrenia, air pollution injury, and other diverse conditions.

D.C., Feb. 19, 2014 — Zoetis Inc. and American Humane Association today announced the official launch of the full clinical trial of the Canines and Childhood Cancer (CCC) Study, a first - of - its - kind effort to examine the effects of animal - assisted therapy on pediatric oncology patients, and their families.

FDA approval and on - going clinical trials attest to the potential of VEGF inhibition as a treatment for many different cancer types in humans, however, the therapeutic effects of VEGF neutralization on cancer growth and metastasis have not been evaluated in the dog.