Sentences with phrase «clinical effects of diseases»

Beyond the clinical effects of diseases like Alzheimer's and other dementias, these disorders also profoundly affect an individual's independence and quality of life as well as the lives of caregivers and others within the support system.

Not exact matches

There are several randomized controlled clinical trials (RCTs) evaluating the effect of probiotic bacteria on the prevention and treatment of allergic disease.

«Our study does not answer the question on possible reasons for infertility but it shows that periodontal bacteria may have a systemic effect even in lower amounts, and even before clear clinical signs of gum disease can be seen,» says Dr. Paju.

A clinical trial assessing the potential of the nutritional supplement inosine to treat Parkinson disease has found that the studied dosages successfully raised participants» levels of the antioxidant urate without producing serious side effects.

Previous research raised the possibility that HDL might not be quite as protective against heart disease as generally believed by cardiologists, especially after several clinical trials of HDL - raising drugs showed little or no effect.

The neuroprotective effects of nicotine were studied in a randomized clinical trial involving 67 subjects in the early stages of Alzheimer's disease, where memory was slightly impaired but decision - making and other cognitive abilities remained intact.

«Imagine a drug that could act like Viagra in the inner ear,» says Lin, who notes that clinical trials are already underway to study the effects of such disease - modifying drugs.

The authors do note that this large study can not definitively prove cause and effect; nonetheless, the findings are strongly consistent with «a wealth of existing observational and clinical trial data to support health benefits of nut consumption on many chronic diseases.»

Whilst established to examine possible safety issues with biologic therapies, it provides the opportunity to look at additional benefits beyond the direct effect on disease severity,» explains William Dixon, MD, MRC clinician scientist / senior clinical lecturer and honorary consultant rheumatologist; Arthritis Research UK Epidemiology Unit, The University of Manchester; and an investigator in the study.

Of the 10 patients enrolled in the study — a clinical trial designed to evaluate safety and feasibility — none of the participants experienced any dangerous side effects and one patient's disease remained stable after 18 monthOf the 10 patients enrolled in the study — a clinical trial designed to evaluate safety and feasibility — none of the participants experienced any dangerous side effects and one patient's disease remained stable after 18 monthof the participants experienced any dangerous side effects and one patient's disease remained stable after 18 months.

«Since several BACE1 inhibitors are currently being evaluated in clinical phase 3 trials for the treatment of Alzheimer's disease, the identification of potential side effects will be of great importance to ensure a positive clinical outcome,» said Dr. Jochen Herms, a Professor of translational brain research at Ludwig - Maximilians - University Munich.

«Currently, we have ongoing clinical trials where we are investigating the effect of faecal microbiota transplantation in treating irritable bowel syndrome and inflammatory bowel disease.»

«Millions of volunteers have participated in clinical trials to help find out more about the effects of treatments on disease, yet the important ethical issue of reporting results has been ignored widely.

The program works by connecting computer - generated drug profiles — including mechanisms of action, clinical efficacy, and side effects — with information about how a molecule may interact with human proteins in specific diseases, such as ovarian cancer.

If doctors had known that TNF - blocking drugs mimic the effects of a major risk factor for the disease, they might have designed their clinical trials differently, he says.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

An initial clinical trial of simvastatin in people with early - stage MS showed reductions in brain lesions, suggesting an effect on the underlying disease process.

However, the authors stress that «further clinical investigations will be essential to establish the optimal dose, duration and safety, and whether vitamin D2 or D3 have different effects on mortality risk, since the available trials are based on elderly populations in general (an age group with high competing risk of death often due to multiple co-existing disease conditions) and they do not typically include cause - specific deaths as the primary outcomes.»

The FDA approved the combination of Mekinist and Tafinlar through its accelerated approval program, which allows the agency to approve drugs to treat a serious disease based on clinical data showing the therapy has a proven effect and clinical benefit to patients.

Survivors should be assessed for physical (e.g.: urinary, sexual, bowel) and psychosocial effects of prostate cancer and its treatment; the focus of assessment should be tailored to the type of cancer treatment received and current disease state to trigger appropriate self - management and clinical management strategies for support and therapy.

Appel and Sacks led three earlier clinical trials that tested ways to reduce the risk of cardiovascular disease and diabetes, providing volunteers with carefully designed diets and measuring the effects on key health indicators.

The meta - analysis included 16 randomized clinical trials to assess the effect of text messaging on medication adherence in chronic disease.

Innovative clinical trial approaches that have proven successful in other disease areas such as oncology (e.g., platform trials, umbrella and basket designs) might be employed with stratification of subjects by AT (N) profile, enabling a data - driven approach to identify the biological stage of disease in which an intervention has maximal treatment effects.

This clinical trial is examining the effects of an oral medication on those with mild to moderate Alzheimer's disease currently on Aricept (Donepezil).

If sufficient 1,25 - dihydroxyvitamin D is produced, it may exert paracrine effects on surrounding T lymphocytes, thereby regulating the tissue - specific immune responses.10 Some support for this hypothesis comes from recent experiments showing that mice fed diets high in vitamin D had significantly fewer clinical and pathological signs of EAE than mice fed a vitamin D — deficient diet.37 Central nervous system levels of 1,25 - dihydroxyvitamin D, but not blood levels, were higher in supplemented mice than in vitamin D — deficient mice and correlated inversely with disease severity.

Genetic data combined with information on gene expression and epigenomics in relevant tissues, and clinical information, can provide clues about the effects of genetic changes within an individual's genome that increase or decrease one's risk of developing type 2 diabetes and its complications, including heart and kidney disease.

Assessment of young blood plasma in Alzheimer Disease model Stanford's neuroscientist Tony Wyss - Coray, who studied effects of «young blood» on brain rejuvenation, has started company (Alkahest) and clinical trial 2 years ago.

A Competitor Mounts the Starting Blocks It would be exciting enough for one AS - targeting rejuvenation biotechnology (or one and a half, if PD03A is counted separately) were making such progress through the clinical pipeline, especially in light of the early hints of a disease - modifying effect.

LUCIDITY, a new clinical trial examining the effects of LMTX ® in patients with mild Alzheimer's disease, is now underway.

Phase II Trials clinical studies conducted to evaluate the effectiveness of the drug for a particular disease or signs or symptoms in patients with the disease or condition under study and to determine the common short - term side effects and risks.

A potential explanation for the secular trend may be that while improved treatment for cardiovascular risk factors or complicating diseases has reduced mortality in all weight classes, the effects may have been greater at higher BMI levels than at lower BMI levels.12 Because obesity is a causal risk factor for hypertension, diabetes, cardiovascular disease, and dyslipidemia,15,19 - 22 obese individuals may have had a higher selective decrease in mortality.18 Indirect evidence of this effect is seen in the findings as the deaths occur at similar time periods in the 3 cohorts, but cohorts recruited at later periods have an increase in the BMI associated with the lowest mortality, possibly suggesting a period effect related to changes in clinical practice, such as improved treatments, or general public health status, such as decreased smoking or increased physical activity.

In the journal Ter Arkh, the use of an infrared sauna as part of therapy of 107 patients with asthma and chronic bronchitis «resulted in a rapid time course of clinical symptoms of diseases, reduced the adaptation period at a health resort, produced a bronchodilatatory effect and helped to return cardiodynamics to normal...»

27 Studies cited by the 2010 DGAC Report demonstrate varied metabolic responses to lowered dietary saturated fat, with certain subpopulations exhibiting adverse rather than improved health outcomes.3 Two recent comprehensive meta - analyses indicate that saturated fat is not linked to heart disease.28, 29 In fact, in a definitive review of forty - eight clinical trials, with over sixty - five thousand participants, the reduction or modification of dietary fat had no effect on mortality, cardiovascular mortality, heart attacks, stroke, cancer, or diabetes.30 Yet, avoiding saturated fat remains a cornerstone of national dietary guidance.

Moreover, one study that had patients with celiac disease consume properly fermented sourdough bread (which was found to contain < 10 ppm of gluten) for 60 days found that there was no adverse effect on clinical symptoms or intestinal pathology.

A systematic review of clinical trials on the health effects of low carbohydrate diets from 2012 shows that low carb diets show significant decrease in body weight and an improvement of all major risk factors for heart disease.

The U.S. National Institutes of Health counts 135 registered trials of curcumin in the last 15 years, according to the study authors, but not one double - blind, placebo - controlled clinical trial on curcumin can support all of the benefits we've been attributing to it, and when it comes to research that seemed to prove curcumin's effects on pancreatic and colon cancers, Alzheimer's disease, and radiation - induced rashes, it seems that the supposed benefits are all cracked up.

In the mouse model of multiple sclerosis (MS), a positive effect of modified fasting and ketogenic nutrition (KD) on disease development and clinical course has been shown in several studies.

In the mouse model of MS, experimental autoimmune encephalomyelitis (EAE), positive effects of modified fasting and ketogenic nutrition on disease onset and clinical course in animals have been observed in several studies.

1935 Effects of the high carbohydrate - low calorie diet upon carbohydrate tolerance in diabetes mellitus 1955 Low - fat diet and therapeutic doses of insulin in diabetes mellitus 1958 Effect of rice diet on diabetes mellitus associated with vascular disease 1976 Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men 1977 Effect of carbohydrate restriction and high carbohydrates diets on men with chemical diabetes 1979 High - carbohydrate, high - fiber diets for insulin - treated men with diabetes mellitus 1981 High carbohydrate high in fibre diet in diabetes 1982 Response of non-insulin-dependent diabetic patients to an intensive program of diet and exercise 1983 Long - term use of a high - complex - carbohydrate, high - fiber, low - fat diet and exercise in the treatment of NIDDM patients 1994 Diet and exercise in the treatment of NIDDM: the need for early emphasis 1999 Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet 2005 The effects of a low - fat, plant - based dietary intervention on body weight, metabolism, and insulin sensitivity 2006 A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes 2006 Effect of short ‐ term Pritikin diet therapy on the metabolic syndrome 2009 A low - fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74 - wk clinical trial

A large number of clinical studies have shown that the essential fats in salmon have direct effect in reducing the risk of arteriosclerosis and associated heart diseases.

As of June 2015, there were 116 clinical trials evaluating the possible anti-disease effect of curcumin in humans, including studies on cancer, gastrointestinal diseases, cognitive disorders, and psychiatric conditions.

Jay W. Pettegrew, Clinical and neurochemical effects of acetyl - L - carnitine in Alzheimer's disease 1995.

Design: A systematic review of the published literature through January 2015 was performed by using sensitive search strategies to identify randomized controlled clinical trials that evaluated the effects of fasting on either clinically relevant surrogate outcomes (e.g., weight, cholesterol) or actual clinical event endpoints [e.g., diabetes, coronary artery disease (CAD)-RSB- and any other studies that evaluated the effects of fasting on clinical event outcomes.

Laboratory and clinical studies on ayurvedic herbal preparations and other therapies have shown them to have a range of potentially beneficial effects for preventing and treating certain cancers, treating infectious disease, promoting health, and treating aging.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

A double - blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mexico.

To date, no trial has tested the effects of increased fruit and vegetable on clinical CVD outcomes (i.e., coronary heart disease events, stroke).

First, most of the evidence regarding the disease effects of carbohydrate to fat ratio is derived from epidemiological and observational studies because it is difficult to address disease endpoints through clinical trials.

Speaking of clinical solutions, you should be aware that products such as Viagra, Cialis, and Levitra may cause certain side effects and unpleasant symptoms in men that have a history of cardiovascular disease.

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial.