Sentences with phrase «clinical findings showed»

Not exact matches

MEDIAL EARLYSIGN SHOWS AI AND EHR DATA CAN BE USED FOR EARLY DETECTION: Researchers from Medial EarlySign, a provider of machine - learning solutions, found that the combination of machine learning technology and electronic health record (EHR) data can be more effective than current clinical tools in identifying the risk of kidney damage in diabetics.

In late clinical - trial findings published Wednesday in the New England Journal of Medicine, the monoclonal antibodies known as solanezumab and bapineuzumab were shown ineffective at changing the downward cognitive trajectory of Alzheimer's patients.

Both sides had struggled up to that point to find a breakthrough, with neither team showing any composure or a clinical edge in the final third.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

I am pissed today hearing about Olivier Giroud three year contract and salary he is earning.That is unfair because Giroud does not deserve it.He has not worked to show that he deserves it.We should look at the quality snd output of our players before paying them.Well its too late now so we should look forward.We do nt need stats to even tell us that Girouf is usually average for arsenal than good at most times.I would have sold him if i was Wenger because he does not deserve to be leading the line still after 3 years and i doubt he will like to warm the bench.He is very lucky to have Wenger as a coach of arsenal london fc.Arsenal has not moved forward because we think getting rid of players is a bad thing.We always hesitate when it comes to selling players we do nt need.Arsenal need a world class cf not a world class cf.Its is time to move forward by addressing our mistakes.Since Van persie left we have needed a cf and ifBenzema is available we need to get rid of who we do nt need so that we move forward.Arsenal do not need Giroud though many may be against my speech.Once the premier league starts and Giroud is our main cf it shows that Wenger has not learnt from his mistakes.Just as we got Cech who to me was a need he needs to just find as a reliable and clinical cf.

Company executives said Tuesday that clinical trials over the last seven years have convinced the firm that its reformulated brand needn't contain two fatty acids found in breast milk that have been shown to be key building blocks for brain cells and the retina.

«Taken together, these data add to the growing body of literature providing evidence that a season of play in a contact sport can show brain changes in the absence of concussion or clinical findings,» they wrote.

If a parent observes that there is some sign of impairment due to a nutritional deficit (either because clinical findings indicate as much or the parent has tuned in to something lab results won't show), then it would make sense to focus more on the details.

Though clinical studies show that technology is better at finding potential tumors, and less likely to result in false alarms, there is not yet long - term research to show whether it saves lives or otherwise improves outcomes.

Clinical findings have repeatedly shown there is a distinct connection between maternal depression and an increased level of emotional and functional problems in infants, prepubescent, adolescent and adult children.

Statistical analysis showed that the finding was independent of other risk factors contributing to conception, such as age, current smoking, socioeconomic status, bacterial vaginosis, previous deliveries, or clinical periodontal disease.

«Decades of clinical research shows that low - calorie sweeteners have been found to aid weight - control when part of an overall healthy diet, and assist with diabetes management,» says Gavin Partington of the British Soft Drinks Association.

In a retrospective analysis of clinical trial data, they found that melanoma patients with highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.

Surprisingly, however, the analysis of clinical trials conducted since 1990 found that the increase in placebo responses occurred only in trials conducted wholly in the U.S.; trials conducted in Europe or Asia showed no changes in placebo responses over that period.

Researchers found that AcK1 closely resembles ShK, a peptide from a sea anemone, which has been shown to suppress autoimmune diseases and is currently in clinical trials for the treatment of multiple sclerosis.

I find myself more concerned with aspects such as checking that the same symbols are used consistently throughout the text, or putting arrows on photos of clinical scans to show the nonspecialist which white blob is actually the tumour.

The findings, which are published in the journal Clinical Science, show that severe allergic lung inflammation was significantly reduced in the mice when the activity of the pro-inflammatory molecules interleukin (IL)-17 A and IL - 17F was prevented using specific antibodies.

Although the analysis found pulses had little impact on «second meal food intake,» the amount of food someone eats at his or her next meal, these findings support longer term clinical trials that have shown a weight loss benefit of dietary pulses.

Approximately 42 % of children in the study with MRI findings of MS developed the first clinical symptoms of the disease about two years after the abnormal MRI, which shows a faster development of the disease than has been reported in adults.

New research findings from Uppsala University and Uppsala Clinical Research Center show that smoking alters several genes that can be associated with health problems for smokers, such as increased risk for cancer and diabetes.

If future clinical studies show comparable findings in patients, Terry Clyburn, M.D., professor of orthopaedics and director of Total Joint Services at the UTHealth Medical School, said antibiotic - containing microspheres could serve to prevent these rare but devastating and often hard - to - treat infections.

Combining the results from all 100 patients showed that the findings were consistent across the three most common clinical subtypes of invasive ductal carcinoma.

The findings add to the growing evidence that girls with autism may show symptoms differently than boys, and that some of the social difficulties experienced by females with autism may be masked during clinical assessments.

Muotri said the findings show it is possible to more effectively stratify ASD individuals for clinical trials by identifying persons who are likely to be more responsive to specific therapies using their «mini-brains» in a dish.

«While the pre-birth programming effect of PETN shows promise for future clinical implications, we must be careful about generalizing findings from animal studies to humans,» Li said.

However, a clinical trial that began almost 10 years ago was terminated early because not only was semagacestat found to fail, patient groups that received the drug showed exasperated symptoms compared to the placebo group.

This finding helps explain why two large clinical trials testing HIV pre-exposure prophylaxis, or PrEP, in women failed to show efficacy.

These findings provide further evidence of ONC201 as an inhibitor of cancer stem cells and support ongoing clinical trials in prostate cancer and glioblastoma that have shown evidence of tumor shrinkage.

Studies in mice specially bred to have features of the disease found that DHA reduces beta - amyloid plaques, abnormal protein deposits in the brain that are a hallmark of Alzheimer's, although a clinical trial of DHA showed no impact on people with mild to moderate Alzheimer's disease.

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

Recent clinical findings have shown that CBD may help reduce seizures and could be a potential new medicine to treat pediatric treatment - resistant epilepsy.

«Our findings show that high - intensity circulating tumor DNA sequencing is possible and may provide invaluable information for clinical decision - making, potentially without any need for tumor tissue samples,» said lead study author Pedram Razavi, MD, PhD, a medical oncologist and instructor in medicine at Memorial Sloan Kettering Cancer Center (MSK) in New York, NY.

By replicating the success of the clinical trial, the findings show that the device is as successful in the general clinical population as it was in participants that met the previous clinical trial criteria.

The findings, which appear online in the Annals of Clinical and Translational Neurology, are the first to show a relationship between fitness and brain structure in older adults, but not younger adults.

Analysis showed that these cells were remapping their routes and finding ways to evade the drug's effect long before any changes could be detected at the clinical level.

In their new study, they extend these findings by showing that Eritoran — a synthetic inhibitor of TLR4, originally developed by Eisai Inc. for treatment of sepsis — improved clinical symptoms and prevented death when administered up to six days after infection with the influenza virus.

Dr. Lin and his colleagues looked at clinical trials and data involving out - of - hospital cardiac arrests that were published in medical journals up to July 2013 and found that adrenaline showed no benefit in survival to discharge from hospital or neurological outcomes.

«Clinical trial shows benefit of yoga for side effects of prostate cancer treatment: Twice - weekly yoga led to better physical, sexual, emotional, and social health, study finds.»

«We have to find ways to intervene when a patient starts showing clinical signs, and if we learn how changes in gut bacteria affect onset or progression, or how the molecules they produce interact with the nervous system, we could use that to create a new kind of personalized medicine.»

The results showed that the mutational spectrum of these genes in PTCL - NOS was similar to that in B - cell lymphoma, in which predominantly missense mutations were found.17, 18 Importantly, our study provided clinical evidence that histone modifier gene mutations, particularly those involved in histone methylation and acetylation, are significantly associated with tumor chemoresistance and disease progression of PTCL - NOS.

Analyzes whole genome and detailed clinical data from nearly 300,000 Icelanders Finds several novel variations in the sequence of the human genome modulating cholesterol levels Five variants are also causally linked to increased risk of coronary artery disease Shows...

2014 — Reported results of first Ebola vaccine clinical trial in Africa — Findings published in the Lancet show that the vaccine candidate produces the same immune response seen in the United States in an African setting.

To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob - Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.Case report.Large referral center for atypical memory and aging disorders, particularly Jakob - Creutzfeldt disease.Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.Despite the long, slow 3.5 - year course, the patient was shown to have pathology - proven sporadic Jakob - Creutzfeldt disease.These findings expand the differential of primary progressive aphasia to include prion disease.

Research, however, shows that the appearance of amyloid does not correlate with clinical symptoms and beta amyloid has repeatedly been found in the brains of one - third of «normal» elderly people.

However, ADCs that use derivatives of calicheamicin, which promotes double - stranded DNA breaks, such as GO and inotuzumab ozogamicin, 40,41 have limited activity in cells with high multidrug resistance protein activity, a phenotype found in a significant fraction of AML patients.42 Another ADC, SGN - CD123A, comprising an engineered form of the CD123 - targeting 7G3 antibody conjugated to a synthetic pyrrolobenzodiazepine dimer, which acts via DNA crosslinking, has entered clinical trials after showing robust activity in preclinical models of AML, including those with multidrug resistance.33

More than a few studies have shown that apple cider vinegar can help lower cholesterol, including this one study published in the British Journal of Clinical Nutrition which found that consuming one tablespoon of apple cider in the morning can help you increase bile production, support your liver function and naturally lower your bad cholesterol (LDL) and triglyceride levels while boosting your levels of good cholesterol (HDL).

A double - blind clinical study of IGOB131 (the unique seed extract found in Perfect African Mango) published in Lipids in Health and Disease (3/2009) showed extraordinary results in weight loss, waist circumference, and body fat percentage.

Their findings, published in The Journal of Clinical Endocrinology and Metabolism, showed that at any given age, average testosterone levels are significantly lower than they were 10 years ago and even lower than 20 years ago.

Resveratrol, an antioxidant found in the skin of grapes, berries, red wine, and peanuts has shown encouraging results for helping restore hormone balance and fertility in women with PCOS, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Here are two full - text articles I found, both of which are randomized, controlled clinical trials, both showing that it does indeed help: 1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145309/ — this one done in South Texas.