Clinical heterogeneity refers to the differences or variations seen within a group of individuals who have a particular medical condition. These differences can be in terms of symptoms, response to treatment, or other factors. It means that even though people may have the same diagnosis, their experiences and outcomes may be different.
Full definition
However, the identification in recent years of XP complementation group D patients with atypical disease presentation, including symptoms of both XP and TTD [8], casts doubt on the ability of such a monoallelic paradigm to
explain clinical heterogeneity in compound heterozygotes.
In the future, this model will be used to assess whether
the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origin.
The mechanisms underlying
this clinical heterogeneity are unclear.
It is an enigmatic tumor presenting with a great genetic and
clinical heterogeneity, both in terms of presentation and outcome.
It is likely, however, that there was
some clinical heterogeneity.