Sentences with phrase «clinical immunotherapy trials»

Not exact matches

With a critical mass of 450,000 patients annually among them, the six centers have agreed to combine their efforts on planning clinical trials in immunotherapy, recruit patients quickly, and share the information learned — which could be the single biggest factor in speeding up drug development.

Speaking of checkpoint inhibitor drugs... Merck's star cancer immunotherapy treatment Keytruda is facing some troubling clinical trial incidents which have now compelled the Food and Drug Administration (FDA) to halt three studies of the drug in multiple myeloma, a rare blood cancer, after a number of patient deaths.

But while thousands of clinical trials on immunotherapy drugs, of which many are predicted to fail, are springing up, the depth of information on neoantigen vaccines is much shallower: Just two studies on neoantigen vaccines for melanoma, recently profiled in Nature, were completed last year in Boston and Germany.

As we explained in our ASCO primer, pharma giants like Merck (mrk) and Bristol - Myers Squibb (bmy) and biotechs like Juno (juno) and Kite Pharma (kite) had a lot to prove through their clinical trial updates on experimental immunotherapies.

«What set Flatiron apart was that it was able to create regulatory grade, real - world data,» O'Day tells Fortune — data that O'Day claims is so well curated, that it «could have theoretically replaced the «control» arm» of one of Roche's own clinical trials for the cancer immunotherapy drug Tecentriq.

In a groundbreaking development, results from a recent clinical trial to treat lung cancer show that a novel immunotherapy combination is surprisingly effective at controlling the disease's progression.

In a head - to - head clinical trial comparing standard chemotherapy with the immunotherapy drug nivolumab, researchers found that people with squamous - non-small cell lung cancer who received nivolumab lived, on average, 3.2 months longer than those receiving chemotherapy.

«We believe these studies and clinical trials that combine immunotherapy with chemotherapy are advancing efforts toward better clinical care and more positive outcomes for our patients at CTCA,» said Dr. Vivek Khemka, Medical Oncologist, CTCA at Western and the WCLC study abstract's principal investigator and senior author.

In fact, for some types of cancer, clinical trials of immunotherapy have reported complete remission in 90 percent of cases.

In clinical trials, immunotherapy drugs have demonstrated strong cancer - fighting abilities.

«Clinical trial using immunotherapy drug combinations to treat lung cancer appears safe.»

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

Roche has four biologic cancer immunotherapy molecules in clinical trials that could work in powerful combinations with each other or with current drugs, says William Pao, global head of oncology discovery in Basel.

She notes that biotech firms are investing heavily in immunotherapy research, and about 40 percent of the roughly 6,000 cancer clinical trials taking place in the United States today include some form of immunotherapy.

Schlom, of the National Cancer Institute, says the next challenge for researchers is to find ways to combine different immunotherapy drugs into single treatments and measure their efficacy in clinical trials.

Nearly 80 percent of peanut - allergic preschool children successfully incorporated peanut - containing foods into their diets after receiving peanut oral immunotherapy (OIT), a clinical trial has found.

Tumors typically have a repertoire of molecular defenses they can use to suppress or evade immune attacks, which is why cancer vaccines and immunotherapies have had mixed results in clinical trials to date.

Priscilla N. Kelly Associate Editor Education: B.Sc., University of Western Australia; Ph.D., University of Melbourne Areas of responsibility: Preclinical development, translational medicine, cancer immunotherapy, drug discovery, clinical trials, gene and cell therapy E-Mail: [email protected]

Biden has also been talking to Los Angeles, California, oncologist and billionaire Patrick Soon - Shiong, who on 11 January announced an industry - led moonshot aimed at testing in clinical trials combinations of cancer immunotherapy drugs, one of most promising new cancer treatments in recent years.

While clinical trials of such immunotherapies in other cancers have shown them to be highly effective in a subgroup of patients, the new study stands out because nearly all patients benefited from the treatment.

More than 500 clinical trials are underway to explore the impact of these and other checkpoint inhibitors on a dozen varieties of cancer, alone or with other immunotherapies, as well as conventional treatments.

In Allison's office, there's a drawing of him playing harmonica, captioned «The Cancer Immunotherapy Clinical Trial Blues.»

In a phase 1b clinical trial with 21 patients, researchers tested the safety and efficacy of combining the immunotherapy drug pembrolizumab with an oncolytic virus called T - VEC.

The immunotherapy drug pembrolizumab — already FDA - approved for other forms of cancer - has been found to be effective in patients with metastatic triple negative breast cancer, according to an international clinical trial led by NYU Langone's Perlmutter Cancer Center.

The results of the Phase II trial now have to be verified in a (multi-centre) clinical Phase III trial — as soon as this trial has been successfully completed and a partner has been found from the pharmaceutical industry, this immunotherapy could be available in a few years for treating apple allergy.

«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»

Partnering with the U.S. Food and Drug Administration allowed Doebele and colleagues to access clinical trial data describing initial tumor response, PFS and OS for 305 patients with stage IIIb or IV non-small cell lung cancer on trials of ALK inhibitors and 355 similar patients on trials of immunotherapies directed at PD - 1.

In 2011, he established the Immunotherapeutics Clinical Core, a specialized phase 1 outpatient unit at MSK that is focused on the conduct of novel immunotherapy trials, with a specific emphasis on pharmacodynamic biomarker identification.

While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials of adoptive immunotherapy.

Clinical trials of a new immunotherapy, pembrolizumab, have shown that it prolongs life significantly for patients with bladder cancer and is active against a rare sub-type of melanoma, called mucosal melanoma.

In collaboration with the Parker Institute for Cancer Immunotherapy (PICI), Wargo's team is developing the first immunotherapy - microbiome clinical trial, with a goal of launching it latImmunotherapy (PICI), Wargo's team is developing the first immunotherapy - microbiome clinical trial, with a goal of launching it latimmunotherapy - microbiome clinical trial, with a goal of launching it later this year.

The Johns Hopkins team tested ImmunoMap's ability to correlate immune responses on receptor sequencing data from T - cells in the tumors of 34 patients with cancer enrolled in a nationwide clinical trial of the immunotherapy drug nivolumab.

To search for other characteristics of ccRCC tumors that influences immunotherapy response or resistance, the researchers used whole - exome DNA sequencing to analyze tumor samples from 35 patients treated in a clinical trial with the checkpoint blocker nivolumab (Opdivo).

While the finding does not directly lead to a test for immunotherapy response yet, Choueiri said, «We intend to look at these specific genomic alterations in larger, randomized controlled trials, and we hope that one day these findings will be the impetus for prospective clinical trials based on these alterations.»

Several types of immunotherapy for glioblastoma are in late - stage clinical trials.

A phase I clinical trial and a phase III clinical trial have been completed for a T - cell based immunotherapy and IL - 13 bacterial toxin fusion protein respectively, both with promising outcomes.

Cancer immunotherapy drugs that block the inhibitory PD - 1 pathway have shown success in clinical trials and are now FDA - approved for melanoma, lung cancer and bladder cancer.

In 2010, she enrolled in a clinical trial of a new immunotherapy drug, called nivolumab, being tested at Moffitt Cancer Center in Florida under the direction of Jeffrey S. Weber, M.D., Ph.D..

We look forward to working with VentiRx to assess its potential in clinical trials, as part of our effort to bring powerful new immunotherapies as quickly as possible to cancer patients.»

Go to our Cancer Immunotherapy Clinical Trial Finder to find clinical trials of immunotherapies for ovarian cancer that are currently enrolling pClinical Trial Finder to find clinical trials of immunotherapies for ovarian cancer that are currently enrolling pclinical trials of immunotherapies for ovarian cancer that are currently enrolling patients.

Many of these novel cancer immunotherapy approaches, which originated from basic science research in CCIR laboratories, are now being explored as new treatment modalities in patients, with a significant number advancing through clinical trials towards FDA approval.

You can also view available immunotherapy clinical trials using our Clinical Trialclinical trials using our Clinical TrialClinical Trial Finder.

NEW YORK AND SAN DIEGO (Sept. 3, 2014)-- The nonprofits Ludwig Cancer Research (Ludwig) and the Cancer Research Institute (CRI) announced today an agreement with VentiRx Pharmaceuticals Inc., a clinical stage biopharmaceutical company, to conduct a clinical trial with motolimod (VTX - 2337) combined with other immunotherapy agents available to Ludwig and CRI through other industry partnerships.

We provide access to the latest medicines and technology, as well as the most advanced clinical trials including novel personalized targeted therapies including precision medicine and immunotherapy - some that are only offered at NCI - designated Comprehensive Cancer Centers like ours.

In addition to being a member of CRI's Clinical Leadership Committee, Dr. Coukos is currently the lead investigator of a CRI - funded clinical trial that is treating ovarian cancer patients with two immunotherapies — MEDI4736, an anti-PD-L1 checkpoint inhibitor, and motolimod, a TLR8 Clinical Leadership Committee, Dr. Coukos is currently the lead investigator of a CRI - funded clinical trial that is treating ovarian cancer patients with two immunotherapies — MEDI4736, an anti-PD-L1 checkpoint inhibitor, and motolimod, a TLR8 clinical trial that is treating ovarian cancer patients with two immunotherapies — MEDI4736, an anti-PD-L1 checkpoint inhibitor, and motolimod, a TLR8 agonist.

Those clinical trials for immunotherapy must stop to help people live longer, not shorter.

With enthusiasm for cancer immunotherapy mounting thanks to recent successes in the clinic with immune - based cancer treatments such as anti-CTLA-4 and anti-PD-1 antibodies, and the FDA approvals of sipuleucel - T prostate cancer vaccine and ipilimumab for the treatment of melanoma, and in light of the many promising immunotherapies now in clinical trials with potential for near - term FDA approval, the Cancer Research Institute launched the first annual Cancer Immunotherapy Awareness Month in June 2013 as a way to increase public awareness of the power of immunotherapy to revolutionize cancer treatment and of the need for continued public support for research to bring these treatments to more patimmunotherapy mounting thanks to recent successes in the clinic with immune - based cancer treatments such as anti-CTLA-4 and anti-PD-1 antibodies, and the FDA approvals of sipuleucel - T prostate cancer vaccine and ipilimumab for the treatment of melanoma, and in light of the many promising immunotherapies now in clinical trials with potential for near - term FDA approval, the Cancer Research Institute launched the first annual Cancer Immunotherapy Awareness Month in June 2013 as a way to increase public awareness of the power of immunotherapy to revolutionize cancer treatment and of the need for continued public support for research to bring these treatments to more patImmunotherapy Awareness Month in June 2013 as a way to increase public awareness of the power of immunotherapy to revolutionize cancer treatment and of the need for continued public support for research to bring these treatments to more patimmunotherapy to revolutionize cancer treatment and of the need for continued public support for research to bring these treatments to more patients sooner.

Members of CRI's Cancer Immunotherapy Consortium (CIC) and the Immunoguiding Program (CIP) of the Germany - based Association for Cancer Immunotherapy (CIMT) announce the completion of the Minimal Information About T cell Assays (MIATA) Project to establish baseline requirements for reporting the results of T cell immune monitoring in clinical trials.

The Clinical Accelerator network includes approximately 80 of the world's leading physician - scientists with expertise in tumor immunology and cancer immunotherapy clinical trials, immune monitoring, and correlative rClinical Accelerator network includes approximately 80 of the world's leading physician - scientists with expertise in tumor immunology and cancer immunotherapy clinical trials, immune monitoring, and correlative rclinical trials, immune monitoring, and correlative research.

We have an active non-interventional trial which examines self - reported quality of life changes for patients who receive immunotherapy outside of the rigid clinical trial environment.