Sentences with phrase «clinical markers for»

Hoheisel and his co-workers now intend to examine whether miR - 192 can be used as a clinical marker for pancreatic cancer and may be used as a starting point for new options for treating or preventing pancreatic cancer.

Not exact matches

Although a considerable body of scientific evidence substantiates the positive correlation between curcumin consumption and a reduction in the risk of cancer, the paucity of suitably designed human clinical trials that clearly demonstrate any direct effect of curcumin on cancer markers may prevent Health Canada from approving a cancer risk reduction claim for curcumin within the current regulatory framework.

They are looking for signs of hypoglycemia or low blood sugar levels, jaundice and other abnormal clinical markers.

Being able to have a subjective marker for clinical response or aid in more prompt diagnosis could be revolutionary.»

In this new study and for the first time, scientists used functional magnetic resonance imaging (fMRI) combined with a standard clinical trial design to derive an unbiased brain - based neurological marker to predict analgesia associated with placebo treatment in patients with chronic knee osteoarthritis pain.

Further, he noted that increased plasma CRP levels are linked to various clinical conditions, which means that CRP is not a highly specific marker for delirium.

«Our study suggests that short height in children is a possible marker of stroke risk and suggests these children should pay extra attention to changing or treating modifiable risk factors for stroke throughout life to reduce the chances of having this disease,» said senior study author Jennifer L. Baker, Ph.D., associate professor in the Center for Clinical Research and Prevention at Bispebjerg and Frederiksberg Hospital and Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, at the University of Copenhagen, in Denmark.

«We've not had cell surface markers for the different stem cell states before, which has made it hard to study them,» says Fredrik Lanner, assistant professor at Karolinska Institutet's Department of Clinical Science, Intervention and Technology.

A new review published by a joint scientific working group of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the International Osteoporosis Foundation (IOF) finds that current evidence continues to support the potential for bone turnover markers (BTMs) to provide clinically useful information for monitoring osteoporosis treatment.

Finding genetic markers for the placebo effect could raise ethical questions about how companies design their clinical trials, Furmark says.

Ultimately, this will provide for current and future studies such as those that evaluate the correlation of biological markers with clinical variables and cancer outcomes, as well as those that identify interactions among biological markers.

As part of our coverage of the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting, held June 2 — 6 in Chicago, we are speaking with Gordon Mills, MD, PhD, chair of the department of systems biology and professor of medicine and immunology at the University of Texas MD Anderson Cancer Center in Houston, about ways to incorporate homologous recombination markers into clinical practice for ovarianClinical Oncology (ASCO) Annual Meeting, held June 2 — 6 in Chicago, we are speaking with Gordon Mills, MD, PhD, chair of the department of systems biology and professor of medicine and immunology at the University of Texas MD Anderson Cancer Center in Houston, about ways to incorporate homologous recombination markers into clinical practice for ovarianclinical practice for ovarian cancer.

This means that samples can be taken before the clinical debut of a disease, to identify markers of value for early diagnosis, improving the scope for curative treatment,» says Ulf Landegren, Professor of Molecular Medicine at Uppsala University and member of SciLifeLab Faculty.

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease, consensus molecular subtype, and microsatellite instability and molecular status, according to the results of an analysis (abstract 3503) of data from CALGB / SWOG 80405 presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.

Testing these structural and functional markers in glaucoma suspects and patients and importantly, in patients enrolled in clinical trials for vision restoration, which I know are few and far between.

One of the most comprehensive reviews on the effects of mindfulness meditation on immune parameters was recently conducted across 20 randomized clinical trials.23 Three of these studies found decreased NF - KB and no strong evidence for changes in interleukin inflammatory markers (interleukin - 6) or TNF - α, but some evidence for a decrease in CRP and increases in telomerase.

Using clinical samples we would like to create an immunoprofile of activated B cells and memory B cells that may provide prognostic markers for dengue immunity and / or immunopathology.

When the molecular imaging research community improves image standardization, there is a greater likelihood of harmonization; i.e., that a specific imaging procedure can be used as a marker across clinical trials; not simply for one clinical trial.

Scientific contributions include publication of the first randomized trials to assess the impact of common complex genetic risk markers, empirically measuring the outcomes of DTC genetic testing, design of a variant classification pipeline and single page summary for reporting clinical results of whole genome sequencing.

Publishing in the journal Nature Genetics the team report a number of markers which they say are associated with self - reporting of clinical diagnosis or treatment for depression.

«This is the first objective, physiological marker for two major psychiatric disorders that, once fully developed into a clinical test, can allow for earlier and more accurate diagnosis, and selection of more appropriate medications for patients.»

So it's very difficult to compare lifestyle changes to clinical markers and that's what we wanted to solve here and make it available for everybody.

The latter are examples of Mendelian randomization studies, enabled by the cheap genotyping of the past decade, which can be considered Nature's own randomized clinical trials, and like RCTs, offer some of the best evidence or refutations of a causal role for risk markers.

Some important studies include: • Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men (1976) • Response of non-insulin-dependent diabetic patients to an intensive program of diet and exercise (1982) • Diet and exercise in the treatment of NIDDM: The need for early emphasis (1994) • Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a low fat, vegetarian diet (1999) • The effects of a low - fat, plant - based dietary intervention on body weight, metabolism, and insulin sensitivity (2005) • A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes (2006) • A low - fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74 - wk clinical trial (2009) • Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes (2011) • Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet (2012)

Now, in the case of protein and bone health, if you look at these direct markers of bone health, there was, for example, a 2009 meta - analysis in the American Journal of Clinical Nutrition that looked at 61 different studies, and they found a strong positive association between protein intake and bone health.

True Health provides testing for various genetic markers with a wide - range of clinical uses.

We therefore examined whether spray - dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons.

Thermography, with its non-radiation, non-contact and low - cost basis has been clearly demonstrated to be a valuable and safe early risk marker of breast pathology, and an excellent case management tool for the ongoing monitoring and treatment of breast disease when used under carefully controlled clinical protocols.

Intervention Studies There have been a number of small clinical interventions addressing various surrogate markers for colon cancer, primarily changes in rectal cell proliferation and polyp recurrence.

Most importantly, the three clinical intervention trials with colon polyp recurrence as an end point also failed to show a protective effect against this surrogate marker for colon cancer (Alberts et al., 2000; Bonithon - Kopp et al., 2000); Schatzkin et al., 2000).

The marker for autoimmune thyroiditis, thyroglobulin autoantibody formation, usually appears prior to the occurrence of clinical signs.

Because previous research has shown that depression, inflammation, and the clustering of metabolic risk markers have cumulative effects on clinical outcomes, 20,21 we summed these 3 age - related - disease risks for each Dunedin Study member and found that 59.5 % of study members had none of the risks, 30.2 % had 1 risk, and 10.3 % had 2 or more risks.