Sentences with phrase «clinical outcome studies»

The safety and efficacy of these methods have been well established through long - term clinical outcomes studies in the field, with the nasal lining protecting the brain from infection just as the blood brain barrier has done.

Whereas enthusiasm for fasting is increasing, clinical relevance remains low because of insufficient human data, including almost nonexistent controlled trials (21, 33 — 36), few clinical outcomes studies (37, 38), lack of correction for inflated type I error rates from multiple hypothesis tests, and limited safety data (39 — 41).

Of further note, despite the different designs, regimens, and study outcomes, the convergence of findings regarding fasting from the 2 epidemiologic clinical outcomes studies (that arose due to data regarding smoking and CAD outcomes, i.e., references 37 and 38) and the findings of interventional studies (most having arisen as extensions of CR research, i.e., references 20, 25 — 36, 39, 40) suggests that a prudent amount of fasting beneficially influences health outcomes.

Studies whose endpoints were surrogate outcomes (e.g., weight loss, LDL cholesterol, and brain - derived neurotrophic factor) that themselves are predictors of clinical events were not considered to be clinical outcomes studies.

Whereas the few randomized controlled trials and observational clinical outcomes studies support the existence of a health benefit from fasting, substantial further research in humans is needed before the use of fasting as a health intervention can be recommended.

Designed and developed programs for the implementation of disease management products; and clinical outcomes studies.

Not exact matches

Examples of forward - looking statements in this news release include statements regarding the effectiveness of the Company's products, the potential outcome of clinical studies, the future success of development activities and the future growth and operating and financial performance of the Company.

Amarin's clinical development program for Vascepa includes a trial known as the REDUCE - IT cardiovascular outcomes study, an 8,175 - patient study commenced in 2011.

A search of Pubmed [a data base containing all medical journal articles] for platelet rich plasma yields 6,811 articles, but less than 20 are clinical studies evaluating patient outcomes for orthopedic sports medicine conditions.

The strengths of the study include the ability to compare outcomes by the woman's planned place of birth at the start of care in labour, the high participation of midwifery units and trusts in England, the large sample size and statistical power to detect clinically important differences in adverse perinatal outcomes, the minimisation of selection bias through achievement of a high response rate and absence of self selection bias due to non-consent, the ability to compare groups that were similar in terms of identified clinical risk (according to current clinical guidelines) and to further increase the comparability of the groups by conducting an additional analysis restricted to women with no complicating conditions identified at the start of care in labour, and the ability to control for several important potential confounders.

The definition of low risk used in the cohort study was based on criteria contained in the NICE Intrapartum Care Guidelines.11 The primary clinical outcome was a composite measure of adverse perinatal outcomes encompassing perinatal mortality and specified neonatal morbidities (box).

Subjects were identified from an ongoing pregnancy outcome study conducted through the California Teratogen Information Service and Clinical Research Program.

Detection bias has been avoided in this study by equal surveillance of clinical outcomes between the two feeding groups by the NICU staff and physicians.

Studies were included if: (a) they were RCTs, (b) the population comprised parents / carers of children up to the age of 18 where at least 50 % had a conduct problem (defined using objective clinical criteria, the clinical cut - off point on a well validated behaviour scale or informal diagnostic criteria), (c) the intervention was a structured, repeatable (manualised) parenting programme (any theoretical basis, setting or mode of delivery) and (d) there was at least one standardised outcome measuring child behaviour.

Today, the DOC Band is the only device supported by clinical studies and over 25 years of documented outcomes.

It was found that the protective effect of breast - feeding was observed only when the analysis was restricted to studies that used medical personnel to assess clinical outcomes, such as atopic dermatitis.

Though clinical studies show that technology is better at finding potential tumors, and less likely to result in false alarms, there is not yet long - term research to show whether it saves lives or otherwise improves outcomes.

When subsequent studies found that CellSearch results had no influence on clinical outcomes, though, insurers lost interest in paying for it.

Placebos are used to help accurately measure clinical responses / outcomes when studying the effects of medications, therapies, and other treatments.

«We believe these studies and clinical trials that combine immunotherapy with chemotherapy are advancing efforts toward better clinical care and more positive outcomes for our patients at CTCA,» said Dr. Vivek Khemka, Medical Oncologist, CTCA at Western and the WCLC study abstract's principal investigator and senior author.

In observational studies, researchers observe exposures and outcomes for patients as they occur naturally in clinical care or real life.

However, the study provides initial clinical evidence that larger, size - matched grafts have the potential to improve outcomes when resurfacing cartilage defects of the femoral head in the hip joint.

«We saw that prevalence rates for depression and anxiety diagnoses were lower among racial and ethnic minorities compared to non-Hispanic whites,» said Owen - Smith, who worked at the Kaiser Permanente Georgia Center for Clinical and Outcomes Research when the study was conducted.

In anticipation of targeted medicines, pharmaceutical and biotechnology companies are increasingly performing genetic studies of clinical trial participants in hopes of identifying genetic profiles that predict therapeutic outcomes.

Since randomized clinical trials — the gold - standard in research — don't accommodate patients» preferences, Zoellner and her research team used a study design called a «doubly randomized preference trial» to investigate whether giving patients a choice affects their treatment outcomes.

To accurately predict treatment outcomes, the research team studied JIA patients» treatment responses and found that epigenetics — or individuals» DNA and the way each body uses its genes — determined one's clinical «fate.»

The next step, says Salem, will be to try to correlate these findings with patient treatment outcomes, initially as a retrospective, or backward looking study, and then hopefully design a forward looking clinical trial to determine which treatments may be best for patients with SBAs.

In 22 percent of cases, the additional clinical information found in the EHR was rated as «possibly» having a clinically significant impact on the interpretation of the head CT. «This study exemplifies the power of EHR's and their potential impact on patient care and positive outcomes.

A first - of - its - kind literature review published in the September issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists ® (ASA ®), suggests although a majority of studies report positive outcomes, there is currently insufficient evidence to support the clinical use of antidepressants for the treatment of postoperative pain.

A new study suggests that insomnia decreases empathy in health care workers and may lead to adverse clinical outcomes and medical errors.

With survival rates improving for ARDS patients, understanding and improving their quality of life outcomes is a clinical and research priority, according to the study's principal investigator Samuel M. Brown, MD, MS, FASE, director of the Center for Humanizing Critical Care at Intermountain Medical Center.

Surrogates often overstate a drug's effectiveness and imply beneficial effects twice as often as studies recording actual clinical outcomes.

The study, Developing an Interventional Stroke Service: Improving Clinical Outcomes and Reducing Cost and Delivering Great Cost Savings Benefits to Health Economy, conducted at the University Hospital of North Midlands, Stoke - on - Trent, U.K., found that mechanical thrombectomy (the use of a device to retrieve a clot from the vessel) in the treatment of stroke reduced the average stroke patient's hospital stay to 14 days when compared to previously recorded 90 days.

The UB researchers are conducting a longitudinal, five - year study of these patients focused on the relationship between cerebral microbleeds, advances in magnetic resonance imaging and clinical outcomes.

The study, «Acceptance and Commitment Therapy to Manage Pain and Opioid Use after Major Surgery: Preliminary Outcomes from the Toronto General Hospital Transitional Pain Service,» is published in the Canadian Journal of Pain, by first author Muhammad Azam, Ph.D. candidate at York University and senior authors Dr. Joel Katz, Affiliate Scientist, Toronto General Hospital Research Institute (TGHRI) and Dr. Hance Clarke, Director of the Transitional Pain Service at TGH, UHN and Clinical Researcher, TGHRI.

The study, published online in Radiology, is among the first to examine what cerebral microbleeds may mean for clinical outcomes in MS.

In brain imaging studies, the OPFC is highly active when people deliberate between actions with uncertain risks and rewards, and clinical reports describe patients, such as Gage, whose inability to consider long - term consequences can lead to tragic outcomes.

In three new studies in the current issue of the International Journal of Infectious Disease, researchers reported on clinical outcomes in the Kingdom of Saudi Arabia (KSA), how long patients will shed virus during their infections, and how the Sultanate of Oman is dealing with cases that have appeared there.

«New therapeutic strategies that target the molecular drivers of invasion are required for improved clinical outcome,» said Dr. Harshil Dhruv, a TGen Research Assistant Professor and lead author of the study.

A second objective of the study was to assess the effect of anti-drug antibody (ADA) on clinical outcomes.

Just four out of 33 studies reported clinical outcomes that could be compared to any standard, while none of the studies compared two or more sizing systems.

«We aren't using older stents anymore, so this study gives us some insight into more up - to - date clinical outcomes,» says Sripal Bangalore MD, an associate professor in NYU Langone's Leon H. Charney Division of Cardiology, Department of Medicine, who was lead author of the study.

«The follow - up period was relatively short — six weeks — and the study was not statistically powered to measure clinical outcomes,» said Tindle, who served as the lead study physician while working at the University of Pittsburgh through the summer of 2014.

«In conclusion, the study by Carrero et al in this issue of JAMA provides the best evidence to date that vitamin K antagonists [anticoagulants] are associated with improved clinical outcomes and no significant increased risk of bleeding in patients with myocardial infarction and atrial fibrillation with advanced CKD.»

In a new study, a hospital surveillance program focusing on reducing the risks of sepsis, known as the two - stage Clinical Decision Support (CDS) system, was found to reduce the risk of adverse outcomes, such as death and hospice discharge for sepsis patients, by 30 % over the course of one year.

«Although hypothermia is a promising strategy to improve resuscitation and brain recovery following cardiac arrest, the results of the current study do not support routine use of cold intravenous fluid in the prehospital setting to improve clinical outcomes,» the authors write.

«Few clinical interventions have had an impact on birth outcomes,» said Professor Jeannette R. Ickovics, the study's lead author.

«Previous studies suggest that reducing heart fat is feasible through weight loss or weight management, but these studies only looked at small numbers of people and there have been no clinical trials linking cardiovascular outcomes with heart fat changes due to weight management interventions.

«This is the first national study to identify specific regions of the United States where residents may be at an increased risk for poor clinical outcomes — including misdiagnoses and late detection — as a result of limited access to specialized gynecologic cancer care,» says David Shalowitz, MD, a fellow in the division of Gynecologic Oncology at the Perelman School of Medicine at the University of Pennsylvania, and lead author on the study.

Shalowitz and colleagues suggest future studies should focus on defining areas with poor clinical outcomes attributed to geographic factors, and creating a comprehensive national, geographically - linked database on the utilization of gynecologic cancer care and clinical outcomes.