However, it is clearly not sufficient, given the failure to achieve remission in about 50 % of patient cases.2 It would be a shame to see further
clinical research efforts simply restating this case.
Facilitated
clinical research efforts by serving as an intermediary for study participants, sponsors, outside consultants and colleagues.
Viral Vectors: Viruses are naturally abundant, optimally characterized delivery vehicles for transfer of genetic information, so they have been the focus of significant
clinical research efforts (see Table 2).
Overall, despite the dramatic therapeutic advances made elsewhere in the melanoma field, the poor prognosis of patients with mucosal melanoma mandates continued emphasis on laboratory and
clinical research efforts in this rare subset of disease.
Not exact matches
As part of a collaborative
effort,
clinical researchers Rebecca Ashare, PhD, an assistant professor of Psychology in Psychiatry, and Robert Schnoll, PhD, an associate professor of Psychology in Psychiatry and director of the Center for Interdisciplinary
Research on Nicotine Addiction, are studying the effects of metformin on smokers to see if it attenuates negative mood and cognitive deficits during withdrawal — symptoms known to be associated with the ability to quit.
However, if you like to be in an area where your
efforts in making all these people work together pays off in fascinating results that actually help patients,
clinical research may be for you.
In an
effort to find out, Stephen P. Juraschek, M.D., Ph.D.,
research and
clinical fellow in general internal medicine at the Johns Hopkins University School of Medicine, and his colleagues used data from the DASH (Dietary Approaches to Stop Hypertension)
clinical trial, a widely popular and often - cited study whose results were first published in 1997.
«Many
efforts to use
clinical documentation in electronic health records for
research aim to identify individual symptoms, like the presence or absence of psychosis,» said Thomas McCoy Jr., M.D., co-first author with Sheng Yu, Ph.D..
The Blueprint is a cooperative
effort among 16 NIH institutes, centers, and offices that supports the development of new tools, training opportunities, and other resources to assist neuroscientists in both basic and
clinical research.
«Until we started our translational
research efforts, basic and
clinical scientists read different journals, and now they are e-mailing each other relevant articles.»
There already has been great
effort to elucidate the mechanisms of gene expression regulation, but it will be important to continue
research to fully realize the potential of these epigenetic therapies and their applications in
clinical settings.
And it cites numerous examples to conclude that «human fetal tissue
research makes a vanishingly small contribution to
clinical and
research efforts.»
The
effort is part of a much broader debate that spans
research and
clinical care over which genetic results should be returned — an ethical, legal, and practical minefield.
The probes targeted to breast cancer have shown great promise so far in breast cancer
clinical trials, and Mankoff and his Penn Medicine colleagues have helped lead this
research effort.
TEDDY's
effort began in 2004 with children from six
clinical centers: three in the U.S. (Barbara Davis Center for Childhood Diabetes at CU Anschutz, the Pacific Northwest
Research Institute in Seattle, and Augusta University in Georgia) and three in Europe (Universities of Turku, Oulu, and Tampere in Finland, Helmholtz Zentrum München in Germany, and Lund University in Sweden).
«It is through collaborative
efforts in
clinical trial
research that we will make a difference in the lives of people with gastrointestinal cancer.»
This synergy enables a physician - scientist to recognize new ways that
clinical care or the understanding of disease mechanisms will benefit from
research and to mount the appropriate
effort.
While more
research is needed to determine whether these approaches could help PD patients, Dr. Greenamyre is optimistic that one or both may ultimately make it into human
clinical trials in an
effort to slow or halt the otherwise inevitable progression of PD.
The Myelin Repair Foundation, which funded this work as part of a multi-institutional
effort to accelerate
research and development of treatments for MS, has entered into a cooperative agreement with the National Institutes of Health to assess guanabenz as a therapeutic candidate in MS
clinical studies.
The
research comes from the Infant Brain Imaging Study (IBIS), a collaborative
effort by investigators at the Montreal Neurological Institute, and four
clinical sites in the United States, coordinated to conduct a longitudinal brain imaging and behavioural study of infants at high risk for autism.
Now, translational
research has emerged as a field in its own right, aided in large part by the National Institutes of Health (NIH) Roadmap for Medical Research, a collection of initiatives that prioritize efforts to shepherd biomedical discoveries into clinical appl
research has emerged as a field in its own right, aided in large part by the National Institutes of Health (NIH) Roadmap for Medical
Research, a collection of initiatives that prioritize efforts to shepherd biomedical discoveries into clinical appl
Research, a collection of initiatives that prioritize
efforts to shepherd biomedical discoveries into
clinical application.
The THaW team conducts
research related to mobile and cloud technology for health and wellness applications, including authentication and privacy tools to protect health records, methods to secure small - scale
clinical networks and
efforts to reduce malicious activity in hospitals.
Through its
effort to develop, produce and distribute a suite of genome RMs, the consortium is providing medical and
research laboratories worldwide with the tools they need to advance
clinical applications of whole genome sequencing, and the FDA with the ability to conduct science - based regulatory oversight of the technology.
«Our hope is that future
clinical,
research, and policy
efforts focus on reducing that number as close to zero as possible.»
We believe that to be successful, microbiome
research will require a coordinated
effort across the international community of biologists, chemists, geologists, mathematicians, physicists, computer scientists and
clinical experts.
The Herbert Irving Comprehensive Cancer Center at NewYork - Presbyterian / Columbia University Medical Center encompasses preclinical and
clinical research, treatment, prevention, and education
efforts in cancer.
Bradner, now at Novartis Institutes for Biomedical
Research in Cambridge, Massachusetts, applauds the overall reproducibility
effort and says it is «reassuring» that his study passed muster, especially because the compound is already in
clinical trials.
She has achieved international recognition for her
research and
clinical efforts in complex medical disorders such as chronic fatigue syndrome and gulf war illness.
The study represents the result of an interdisciplinary
effort, involving several
clinical departments and scientists from different
research centers.
Founded in 2003, the Spinal Muscular Atrophy Foundation is a nonprofit organization dedicated to accelerating progress towards a treatment and cure for Spinal Muscular Atrophy through targeted funding of
clinical research and novel drug development
efforts.
As Minikel explained on CureFFI.org, the registry represents an
effort by a coalition of prion disease advocacy groups — the CJD Foundation, the CJD International Support Alliance, and the Prion Alliance — to fill an unmet need: a centralized way for those who want to participate in prion disease
research to make their voices heard, and in the process, support
clinical research on these conditions:
As a faculty member in the Vanderbilt Hereditary Cancer Clinic, Pal's
clinical and
research efforts are focused on individuals with inherited cancer risk across diverse populations.
About the SMA Foundation Founded in 2003, the Spinal Muscular Atrophy Foundation is a nonprofit organization dedicated to accelerating progress towards a treatment for Spinal Muscular Atrophy through targeted funding of
clinical research and novel drug development
efforts.
This is the first
clinical trial of its kind and The Human Trial is the first film to take us backstage into the world of cure
research: the formidable obstacles and grinding
effort, the complexity of the disease and the science, what it takes to harvest cells, regulatory rules and the $ 5 billion plus it typically takes to bring a drug to market.
These
efforts include four Dream Teams, five
Research Teams, including two Convergence Teams bringing together computational experts with
clinical oncologists.
The Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork - Presbyterian Hospital encompasses pre-
clinical and
clinical research, treatment, prevention and education
efforts in cancer.
Researchers Matthew Porteus, MD, PhD, associate professor of pediatrics at Stanford School of Medicine; Frank Longo, MD, PhD, professor of neurology at Stanford School of Medicine; and Steve Finkbeiner, MD, PhD, director of the Gladstone Institutes» Taube - Koret Center for Neurodegenerative Disease
Research, will collaborate with
clinical efforts at the UCSF Memory and Aging Center, under the direction of Bruce Miller, MD, PhD.
The Spinal Muscular Atrophy Foundation is a nonprofit organization dedicated to accelerating progress towards a treatment and cure for spinal muscular atrophy through targeted funding of
clinical research and novel drug development
efforts.
The Chinese Thousand Talents Plan scholarship and the Heilongjiang Province Longjiang Scholar Program (for Dr. Legro's
effort) and the National
Clinical Trial Base in Chinese Medicine in Gynecology were among the funders of this
research
Penn Medicine has been at the forefront of rare disease
research for decades, and these
efforts — as well as many of its other
research and
clinical milestones — are being honored this year as part of the Perelman School of Medicine's 250th anniversary celebration.
«While much additional
research must be done to determine the feasibility of this nanoparticle approach as a vision restoration therapy, our results encourage further
effort aimed at achieving this critical
clinical objective,» said study co-author David Pepperberg, PhD, Searls - Schenk Professor of ophthalmology and visual sciences at UIC.
This collaborative
effort will translate
clinical research into policy and practice recommendations that improve the quality and reduce the cost of senior health care and promote healthy aging.
Through regional networks in the U.S. like the Pediatric Neuromuscular
Clinical Research (PNCR) Network and Project Cure, and international organizations such as the International Coordinating Committee (ICC) and TREAT - NMD, the SMA community has collaborated effectively on recruiting patients, establishing standards of care, standardizing outcome measures, and supporting multi-site clinical efforts, such as the Biomarkers for SMA (BforSMA) and the PNCR Network Natural History
Clinical Research (PNCR) Network and Project Cure, and international organizations such as the International Coordinating Committee (ICC) and TREAT - NMD, the SMA community has collaborated effectively on recruiting patients, establishing standards of care, standardizing outcome measures, and supporting multi-site
clinical efforts, such as the Biomarkers for SMA (BforSMA) and the PNCR Network Natural History
clinical efforts, such as the Biomarkers for SMA (BforSMA) and the PNCR Network Natural History studies.
Some
research efforts are closer to
clinical implementation, including developing improvements in
clinical management of rare diseases and trials of small molecule therapies for inherited and mosaic genetic disorders.
Our clinicians work closely with our scientists on basic,
clinical, and translational
research activities in an
effort to advance our understanding of these unique tumors.
Dr. Roggin co-leads the Chicago Pancreatic Cancer Initiative, which is an institutional
effort to apply comprehensive geriatric assessments, sarcopenia measurements, and genomic
research to improve the
clinical care of patients with pancreatic cancer.
The AADCRC program is the cornerstone of NIAID
efforts to promote multidisciplinary basic and
clinical research on the immunological basis, pathobiology, diagnosis, treatment, and preven tion of asthma and allergic diseases.
According to Dr Adil Mardinoglu, SciLifeLab Fellow and leader of the systems biology
effort in the project: «We are now in possession of incredibly powerful systems biology tools for medical
research, allowing, for the first time, genome - wide analysis of individual patients with regards to the consequence of their expression profiles for
clinical survival.»
«His investigation of pediatric brain and spinal cord tumors is one of the innovative
clinical -
research efforts that advances the University of Chicago Hospitals to the forefront of medicine.»
About the Spinal Muscular Atrophy Foundation Founded in 2003, the Spinal Muscular Atrophy Foundation is a nonprofit organization dedicated to accelerating progress towards a treatment for Spinal Muscular Atrophy through targeted funding of
clinical research and novel drug development
efforts.