An early, outsourced
clinical research study with real patients was encouraging, but there are many potential pitfalls yet to come, said University of North Carolina diabetes researcher Dr. John Buse, who was briefed by Google on the lens last week.
Not exact matches
In response to «Effects of Energy Drinks Mixed
with Alcohol on Behavioral Control: Risks for College Students Consuming Trendy Cocktails,» a
study to be published in the July issue of Alcoholism:
Clinical & Experimental
Research, Dr. Maureen Storey, senior vice president of science policy for the American Beverage Association, issued the following statement:
Clinical studies indicate that moderate coffee consumption is benign or mildly beneficial in healthy adults,
with continuing
research on whether long - term consumption inhibits cognitive decline during aging or lowers the risk of some forms of cancer.
Clinical studies indicate that moderate Kona consumption is benign or mildly beneficial in healthy adults,
with continuing
research on whether long - term consumption inhibits cognitive decline during aging or lowers the risk of some forms of cancer.
Clinical studies indicate that moderate coffee consumption is beneficial in healthy adults,
with continuing
research on whether long - term consumption inhibits cognitive decline during aging or lowers the risk of some forms of cancer.
Clinical studies indicate that moderate Kona consumption is benign or mildly beneficial in healthy adults,
with continuing online
research on whether long - term consumption inhibits cognitive decline during aging or lowers the risk of some forms of cancer.
While Boobie Bar ® has not been included in a peer - reviewed
clinical study, Nurse Wendy conducted anecdotal
research prior to launching her product and found that among exclusively pumping women
with an established milk supply, the average daily increase in supply is 1.5 to 4.6 ounces.
The latter
research findings form the basis for patents and
clinical studies with the aim to create a pharmaceutical drug for relief of menopausal symptoms.
Finally, neurodevelopmental
research has suggested that the factors in breast milk that may be responsible for the improved cognitive abilities of breastfed children may involve long chain polyunsaturated fatty acids and, particularly, docosahexaenoic acid (DHA), 10
with some
clinical studies in which infant formula was supplemented
with DHA suggesting possible improvements in visual acuity and cognitive ability in preterm infants given the DHA - supplemented formula.13
All
study participants gave written informed consent and the
study was approved by the Monash University Human
Research Ethics Committee (approval number CF12 / 0348 -2012000146), and the trial registered
with the Australia and New Zealand
Clinical Trial Registry (registration number 12611000468921).
We conducted our
study in conjunction
with the
clinical trials and epidemiology
research unit, which is an independent organisation funded by the National Medical Research
research unit, which is an independent organisation funded by the National Medical
Research Research Council.
UKPDS - Implications for the care of people
with Type 2 diabetes The United Kingdom Prospective Diabetes
Study (UKPDS), the largest clinical research study of diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate treat
Study (UKPDS), the largest
clinical research study of diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate treat
study of diabetes ever conducted, has provided conclusive evidence that the life threatening complications of Type 2 diabetes (non insulin dependent diabetes) can be significantly reduced by appropriate treatment.
As part of a collaborative effort,
clinical researchers Rebecca Ashare, PhD, an assistant professor of Psychology in Psychiatry, and Robert Schnoll, PhD, an associate professor of Psychology in Psychiatry and director of the Center for Interdisciplinary
Research on Nicotine Addiction, are
studying the effects of metformin on smokers to see if it attenuates negative mood and cognitive deficits during withdrawal — symptoms known to be associated
with the ability to quit.
It could also identify those patients
with early signs of autoimmunity who might be good candidates for
clinical research studies.
For those
with a
research background, it could mean learning
clinical study design and the bioethics of human
research.
«In addition, we believe our
study design sets an important precedent for other genetic diseases and will help inform discussions of how
clinical research can coexist
with deep concerns about genetic privacy and patient autonomy.»
People diagnosed
with cancer gained 3.34 million years of life thanks to cancer
clinical trials run by SWOG and supported with public funds, according to new study results to be presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO), the world's largest clinical cancer research
clinical trials run by SWOG and supported
with public funds, according to new
study results to be presented at the 53rd Annual Meeting of the American Society of
Clinical Oncology (ASCO), the world's largest clinical cancer research
Clinical Oncology (ASCO), the world's largest
clinical cancer research
clinical cancer
research meeting.
«Our
study shows the significant impact of adding carotid plaque measurement using vascular ultrasound and coronary calcium scoring
with CT scan to our conventional assessment for cardiovascular disease,» says Roxana Mehran, MD, the
study's co-lead author and Director of Interventional Cardiovascular
Research and
Clinical Trials at the Zena and Michael A. Weiner Cardiovascular Institute at Mount Sinai Heart at Icahn School of Medicine at Mount Sinai.
Another problem is that modeling
studies, like this one, are inherently less powerful than other kinds of medical
research: randomized
clinical trials, the gold standard in medical
research, in which patients are randomly assigned different treatments or no treatment; case - control
studies, which compare patients who have a condition
with those who do not; or cohort
studies, which determine the risk of contracting a disease by
studying a group of people
with similar demographics.
Moreover, greater numbers of Plasmodium parasites correlated
with increased rates of Ebola survival, according to a dozen collaborating
research groups in the new
study, published in
Clinical Infectious Diseases.
Led by Dr Steven Marwaha, a
clinical academic Psychiatrist, the
research analysed data from the Avon Longitudinal
Study of Parents and Children and found that teenage cannabis use at least 2 - 3 times weekly is directly associated
with suffering from symptoms of hypomania in later years.
Dr. Criner said that despite the
clinical trial's finding that the statin drug did not help
with COPD flare - ups, information gleaned from this
study should help inform other
research into the inflammatory nature of COPD.
«The complexity of Lyme disease, combined
with lack of biomarkers to measure infection, has slowed progress,»
study collaborator John Aucott, head of the Johns Hopkins Lyme Disease
Clinical Research Center..
«One criticism of the PARP drugs is they are not active in patients who have developed resistance to other therapies, but we found veliparib appears to be effective in some platinum - resistant patients
with recurrent or persistent disease,» said Robert L. Coleman, MD, lead author of the
study and professor and vice chair of
clinical research at the University of Texas MD Anderson Cancer Center, Houston.
With survival rates improving for ARDS patients, understanding and improving their quality of life outcomes is a
clinical and
research priority, according to the
study's principal investigator Samuel M. Brown, MD, MS, FASE, director of the Center for Humanizing Critical Care at Intermountain Medical Center.
«This is the question we asked ourselves, particularly in the case of certain patients born
with broken bones who, even as newborns, were neither able to move properly nor breathe unaided,» explains Dr. Ellen Knierim, a researcher at Charité's NeuroCure
Clinical Research Center and the
study's first author.
Whilst established to examine possible safety issues
with biologic therapies, it provides the opportunity to look at additional benefits beyond the direct effect on disease severity,» explains William Dixon, MD, MRC clinician scientist / senior
clinical lecturer and honorary consultant rheumatologist; Arthritis
Research UK Epidemiology Unit, The University of Manchester; and an investigator in the
study.
«Based on our
research criteria, parents report that the girls in our
study with autism seem to have a more difficult time
with day - to - day skills than the boys,» says Allison Ratto, Ph.D., lead author of the
study and a
clinical psychologist within the Center for Autism Spectrum Disorders at Children's National.
Furthermore, the report accuses the British Homeopathic Association (BHA), which had submitted evidence to the panel, of cherry - picking, and even, in one case actively misrepresenting,
research into the treatment (a famous
study that concluded its findings were «compatible
with the notion that the
clinical effects of homeopathy are placebo effects» was cited by the BHA as evidence of the treatment's efficacy.)
Professor Kristina Akesson,
Clinical and Molecular Osteoporosis
Research Unit at Lund University, Chair of the IOF Capture the Fracture Campaign, stated, «This
study concludes that in the population sample of elderly women, vitamin D insufficiency sustained over 5 - years was associated
with increased 10 - year risk of osteoporotic fracture.»
«This
study demonstrates that CRFA is an effective long - term therapeutic option for managing pain, and improving physical function and quality of life, for patients suffering from painful knee osteoarthritis when compared
with intra-articular steroid injection,» according to the
clinical trial report by Leonardo Kapural, MD, PhD, of the Center for Clinical Research, Winston - Salem, N.C., and col
clinical trial report by Leonardo Kapural, MD, PhD, of the Center for
Clinical Research, Winston - Salem, N.C., and col
Clinical Research, Winston - Salem, N.C., and colleagues.
Hip replacement surgery not only improves quality of life but is also associated
with increased life expectancy, compared to people of similar age and sex, reports a
study in
Clinical Orthopaedics and Related
Research ® (CORR ®), a publication of The Association of Bone and Joint Surgeons ®.
However, RA professionals are increasingly involved
with products during the
research and development phases, in the design and monitoring of
clinical studies, marketing, advertising, and communications.
Yong, a neuroscientist, initially had the idea to test the acne medicine in an animal model since minocycline has many anti-inflammatory properties that he thought could be useful in treating MS. Soon after obtaining successful
research results, in
studies also supported by the MS Society of Canada and MSSRF, Yong teamed up
with Metz who led the transition into a pilot
clinical trial, then a Phase 2, and finally the definitive Phase 3 trial.
In a randomized, phase 2 multi-center
clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove
Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared
with the same drug given in combination
with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients
with B - raf mutations.
His colleague Alex Liddle, an Arthritis
Research UK clinical research fellow who ran the study, added: «Partial and total knee replacements are both successful treatments and a large proportion of patients with end - stage knee osteoarthritis are suitable for
Research UK
clinical research fellow who ran the study, added: «Partial and total knee replacements are both successful treatments and a large proportion of patients with end - stage knee osteoarthritis are suitable for
research fellow who ran the
study, added: «Partial and total knee replacements are both successful treatments and a large proportion of patients
with end - stage knee osteoarthritis are suitable for either.
The Myelin Repair Foundation, which funded this work as part of a multi-institutional effort to accelerate
research and development of treatments for MS, has entered into a cooperative agreement
with the National Institutes of Health to assess guanabenz as a therapeutic candidate in MS
clinical studies.
In November 2001, the Drug Controller of India met
with representatives from pharmaceutical companies,
study sites, and
clinical research organizations to discuss the issues.
In a report about their
study published online Oct. 17 in
Clinical Cancer
Research, the researchers described minimal or zero tumor progression in mice treated
with the microencapsulated 3BrPA.
Garet Lahvis was a 4th - year assistant professor of surgery at the University of Wisconsin (UW), Madison, when his department chair told him that his
studies of social motivation and communication in mice —
research with implications for autism and drug addiction — had moved too far from the department's focus on
clinical plastic surgery and that the department would have to let him go.
Pharmacogenomics — the
study of how genes affect responses to drugs — is becoming more important in drug - development
research and
clinical trials,
with a view toward decreasing side effects and increasing the efficiency and efficacy of drugs in patients
with the right genetic profiles.
In a separate
study, Menno de Jong of the Oxford University
Clinical Research Unit in Ho Chi Minh City, Vietnam, found higher levels of cytokines in tissues from H5N1 victims than in those
with ordinary seasonal flu.
Conducted by Prof Rose McGready and Assoc. Prof Daniel Henry Paris from the Shoklo Malaria
Research Unit (SMRU) in Mae Sot, Thailand, and the Mahidol Oxford
Research Unit (MORU) in Bangkok, affiliated to Oxford University, UK, in collaboration
with Prof John Antony Jude Prakash of the Dept. of
Clinical Microbiology, Christian Medical College, Vellore, India, the
study, «Pregnancy outcome in relation to treatment of Murine typhus and Scrub typhus infection: a fever cohort and a case series analysis,» will be published in the November 20th, 2014 issue of PLOS Neglected Tropical Diseases.
Beginning
with the Nazi Doctors» Trial at the 1946 Nuremberg Trial (1), coverage includes publication of Henry Beecher's «Ethics and
Clinical Research» (2), The New York Times exposure of the public health service syphilis study in Macon County, Alabama (the infamous «Tuskeegee case»)(3), the University of Pennsylvania / Gelsinger gene transfer case, and The Washington Post series on international clinical drug testing abu
Clinical Research» (2), The New York Times exposure of the public health service syphilis
study in Macon County, Alabama (the infamous «Tuskeegee case»)(3), the University of Pennsylvania / Gelsinger gene transfer case, and The Washington Post series on international
clinical drug testing abu
clinical drug testing abuses (4).
The company paid scientists at Duke University School of Medicine and Florida
Clinical Research Center to run a four - week
study involving 80 children ages eight to 12 — 40
with ADHD who were not taking medications and 40 neurotypical, or those whose functions were within a normal range.
This
research is part of the Pulmonary Nodule Plasma Proteomic Classifier (PANOPTIC)
study, a
clinical trial of 685 patients 40 years old or older,
with newly discovered lung nodules 8 to 30 millimeters in diameter as shown on a recent (fewer than 60 days old) CT scan.
«There is very little data on the time cost of healthy eating,» said Pablo Monsivais, Ph.D., M.P.H., the
study's lead author and a senior university lecturer
with the Center for Diet and Activity
Research at the University of Cambridge School of
Clinical Medicine in England.
«The strength of our
study is that it provides a real world assessment of how testing in patients
with chest pain has an impact on the subsequent health of patients
with chest pain,» said lead author Pamela Douglas, M.D., Geller Professor of
Research in Cardiovascular Diseases at the Duke
Clinical Research Institute.
«For the baseline scores, it works kind of like a trade - off: the older the age, the lower the performance,» says Joy Taylor,
study co-author and researcher
with the Stanford University / VA Palo Alto Health Care System's Aging
Clinical Research Center.
The new
study, based on recordings from the brains of 37 patients fitted
with NeuroPace implants, confirmed previous
clinical and
research observations of daily cycles in patients» seizure risk, explaining why many patients tend to experience seizures at the same time of day.