Sentences with phrase «clinical sequence data»

Over the summer, I wrote a post emphasizing the importance of clinical sequence data sharing in repositories like the ClinSeq database, which has already proven life - saving (or life - changing) for thousands of patients and their families.

Not exact matches

Participants in United Therapeutics» clinical trials now have their genomes sequenced and researchers at the company plan to correlate patient outcomes with that genomic sequence data.

During his speech, Biden repeatedly stressed the importance of breaking down the regulatory and structural barriers to pooling clinical trial and genomic cancer sequencing data.

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMA.

Researchers working with stem cells should follow the example of their colleagues in genetic sequencing and clinical research, setting up global networks for sharing data, materials, and intellectual property, according to a report released today in Washington, D.C..

To this purpose, GenProfile utilizes a powerful technology platform, which involves proprietary high - throughput technologies for gene sequence comparison (e.g., multiplex sequence comparison), genotyping (MALDI - TOF minisequencing), unique approaches to data analysis and interpretation, as well as a large network of clinical collaborators.

The Johns Hopkins team tested ImmunoMap's ability to correlate immune responses on receptor sequencing data from T - cells in the tumors of 34 patients with cancer enrolled in a nationwide clinical trial of the immunotherapy drug nivolumab.

Professor Jean - Claude Dujardin from ITM points out: «It took us more than five years to collect an unprecedented sequencing data set from clinical isolates in the Indian sub-continent and publish a first analysis last year.

«The different clinical presentations, and some very preliminary [DNA] sequencing data, suggest that the Hendra virus may be somewhat different in this outbreak,» says epidemiologist Hume Field of the Australian Biosecurity Cooperative Research Centre for Emerging Infectious Diseases in Brisbane.

«We retrospectively analyzed the data from the DTI sequence to derive measures of white matter integrity, which we compared to clinical measures and subsequent outcome measures 6 months to 2.5 years after the initial evaluation.»

In the case of clinical next - generation sequencing, and in genetic cohort studies and biobanks, pertinent issues include the interpretation of data, data storage, data sharing, informed consent and identifiability / privacy [20][26].

It will house data from a new era of programs that will sequence the DNA of patients enrolled in NCI clinical trials.

Researchers are building a database of DNA sequence, functional and epigenomic information, and clinical data from studies on type 2 diabetes and its macro - and microvascular complications, and creating analytic tools to analyze these data.

Essential systems are now in place to isolate and sequence pathogens from many thousands of clinical samples per year, generating an unprecedented amount of raw genetic data.

«It's amazing to see studies going on at multiple locations in the Mekong region, where precise clinical measurements are being made in patients undergoing treatment for malaria, and within a few months these clinical data are connected to genome sequence data on the parasites,» says Professor Dominic Kwiatkowski, CGGH Director, as he reflects on the strength of the collaboration with TRAC.

Cell biology has continued to expand ever since, extending its impact on clinical medicine and pharmacology while drawing on new technologies in bioengineering, high - resolution imaging, massive data handling, and genomic sequencing.

EPIC is a longitudinal study at UCSF that is tracking nearly 600 patients for ten years using clinical evaluations, blood draws, imaging data, and full genome sequencing.

Building the fourth generation of GATK (GATK4) on Cloudera Enterprise and utilizing the Spark distributed computing framework to speed research, the Broad Institute is facilitating better understanding of genomic sequencing, resulting in faster data exploration and ultimately empowering better clinical decisions.

PHG Foundation has previously carried out work examining the implications of whole exome and genome sequencing on clinical services which identified data sharing as a key priority for these technologies to be deployed effectively for clinical benefit.

The CGGH is leading this area of analysis by integrating the clinical data with genome sequencing data on 1,000 parasite samples collected by the study.

The MRC Centre for Genomics and Global Health (CGGH) is supporting TRAC by leading a genome - wide association study and population genetic analysis that integrates TRAC clinical data with genome sequencing data generated through a partnership with MalariaGEN and the Wellcome Trust Sanger Institute.

Developing standards and procedures for the use of sequencing information in clinical medicine is an urgent need with numerous obstacles to integrity and storage of sequencing data, interpretation, and responsible clinical integration.

Genome sequencing of the TRAC clinical samples has now been completed, generating terabytes of data that were processed by the sequence - analysis pipeline team led by Jim Stalker, to produce quality - controlled information about many thousands of variants for each sample.

This project produced data demonstrating that 185 CHIKV sequences associated with the 2014 Caribbean outbreak segregate into 2 well - supported clades, that multiple phylogenetic subclades are associated with clinical phenotypes, and that multiple international transmission events were observed.

Yet I can also tell you that they're inherently noisy — particularly for targeted sequencing data — and I would not be confident in using them to guide clinical care.

Analyzes whole genome and detailed clinical data from nearly 300,000 Icelanders Finds several novel variations in the sequence of the human genome modulating cholesterol levels Five variants are also causally linked to increased risk of coronary artery disease Shows...

Clinical Studies: Our clinical core, led by Dr. Kurt Christensen, conducts economic analyses alongside prospective clinical studies to better understand the full costs of sequencing and to collect real - world data about health care utilization and clinical outcomes following genomiClinical Studies: Our clinical core, led by Dr. Kurt Christensen, conducts economic analyses alongside prospective clinical studies to better understand the full costs of sequencing and to collect real - world data about health care utilization and clinical outcomes following genomiclinical core, led by Dr. Kurt Christensen, conducts economic analyses alongside prospective clinical studies to better understand the full costs of sequencing and to collect real - world data about health care utilization and clinical outcomes following genomiclinical studies to better understand the full costs of sequencing and to collect real - world data about health care utilization and clinical outcomes following genomiclinical outcomes following genomic tests.

Critical data gathered from the NSIGHT projects will help to address technical, medical, behavioral and economic questions surrounding newborn sequencing — and ultimately, will aid in the development of best clinical practices and provide guidance on the implementation of sequencing in newborns.

Microsatellite genotypes were obtained for 203 clinical infection samples from eight locations, and Illumina paired - end sequences were obtained to yield high coverage genome - wide single nucleotide polymorphism (SNP) data for 65 clinical infection samples from four locations.

Topics that will be explored include: • Cellular and developmental origins of pediatric cancer • Key findings of pan-cancer analysis efforts • Computational pipelines to analyze large - scale sequencing data • Opportunities for leveraging existing cancer genomics datasets • Strategies for integrative analysis of germline and somatic variants • Correlation of germline / somatic variation to clinical features such as tumor subtype.

In addition to the functional data, high - resolution structural images were obtained using a standard clinical T1 - weighted sequence.

The aim of this study was to evaluate the correlation between antimicrobial resistance (AMR) profiles of 96 clinical isolates of Actinobacillus pleuropneumoniae, an important porcine respiratory pathogen, and the identification of AMR genes in whole genome sequence (wgs) data.

Increasingly, MLST is being performed using next - generation sequencing (NGS) data by reference laboratories and for clinical diagnostics.

Kp isolated from screening swabs and clinical diagnostic samples were characterized using whole genome sequencing and combined with epidemiological data to identify likely transmission events.

All data of the PedBrain - Tumor consortium including all sequence data generated by the sequencing work packages (WP5 - 9) and histopathological and clinical annotations will be stored in this data center.

Tags for this Online Resume: Research, Infectious Diseases, Statistics, Medical Devices, Spine, Orthopedics, Sales, Pennsylvania, Clinical Research Manager, Biology, Immunological Assays, Client Relations, Social Media, Large - Scale Studies, Vaccines, Market Analysis, Event Planning, Sales Cycle Management, Data Analyses, qPCR, Genome Sequencing, Global Research, Journal Publications, Published Writer, Media Relations, Presenatations, Team Leadership

His current work focuses on the development and evaluation of novel molecular biology, sequencing and bioinformatics methods to aid the interpretation of genome and metagenome scale data generated in clinical and public health microbiology.