Sentences with phrase «clinical significance»

The potential clinical significance of the bacteria needs to studied, and any public health impacts understood, he added.

In recent years DNA - and RNA - based surveys of tumor genome and expression profiling have produced a plethora of leads on genes with clinical significance.

There are also many rare variants whose relationship to disease are not well understood at this time, which are referred to as variants of uncertain clinical significance.

Nevertheless, owing to its important clinical significance, a small number of studies have investigated the effect of different interventions on peak hip extension angles.

However, statistically significant findings in large samples does not necessarily yield clinical significance.

The long - term effectiveness and clinical significance of three cost - effective training programs for families with conduct - problem children.

Of clinical significance in terms of helping people with mental illness, the patients» happiness was unrelated to the severity or duration of their illness, to cognitive or physical function or to socioeconomic factors such as age and education, which among healthy adults have been linked to a greater sense of well - being.

The clinical trial wasn't finished, the data wasn't peer - reviewed, and the release contained no stats that could be analysed for clinical significance.

These neuropathological mechanisms may bear clinical significance as related to the functional alteration of neuromuscular connections associated with DM1.

Effect sizes were calculated to assess clinical significance [34].

These results support and extend the findings of the PRECISION trial, demonstrating noninferiority for the primary cardiovascular outcomes for moderate doses of celecoxib compared with naproxen or ibuprofen.6 These findings may have the greatest clinical significance in the elderly, who have a high prevalence of arthritis and hypertension.

Mothers who have taken antidepressant medication during pregnancy should be reassured about the neuro - development of their child because long - term studies have not shown adverse effects, except for subtle differences whose clinical significance remains to be confirmed.

Adolescents with a chronic illness such as IBD may be at higher risk for difficulties in social functioning and anxiety or depression symptoms than healthy adolescents, but the difficulties do not reach clinical significance for most adolescents.

This study has potential clinical significance since children with a history of ROP are not only at increased risk for visual impairments from the ROP itself, but are also at increased risk for developing other ocular disorders later in life.»

Although he and others caution about extrapolating the findings to humans, Brune nonetheless calls it «potentially of enormous clinical significance.»

The drug was safe and well - tolerated and also showed a trend to decreased mortality, though this did not achieve clinical significance.»

The findings have major clinical significance, according to Professor Martin L. Olsson, a consultant in transfusion medicine.

Transcranial magnetic stimulation / transcranial direct current stimulation (tDCS) can induce acute and short - duration beneficial effects on cognitive function, but the therapeutic clinical significance in AD is unclear.

«It is important to be able to show that these six mutations of unknown clinical significance are, in fact, loss - of - function mutations,» Ding said.

Without a mechanism for extending its telomeres, the replicative potential of a cancer cell faces an absolute barrier to achieving clinically significant growth, and what is today a death sentence (or at best a chronic or potentially relapsing disease) is transformed into a benign lesion, of no more clinical significance than a cyst or plantar hyperkeratosis.

Major GC, Doucet E, Trayhurn P, Astrup A, Tremblay A. Clinical significance of adaptive thermogenesis.

Cholesterol is a complicated molecule in the body that comes in many different forms — each with different clinical significance.

This is not wishful thinking: grape seed extract benefits hold clinical significance.

The evaluation also included (a) the doctor's follow - up report, which continued restrictions from contact sports but cleared J.P. for schoolwork; (b) the report card data and structured anecdotal information from his teachers and the school nurse, which generally did not approach clinical significance; and (c) two pairs of classroom observations, which she and the school counselor separately conducted.

A randomized, prospective study comparing the two approaches found similar complication rates.4 The scrotal approach had the advantage of inducing less self - trauma and of being about 30 percent quicker to perform (though the absolute difference, from about 5 minutes to 3 minutes, is of doubtful clinical significance).

Leptospirosis is an infectious disease of historic & resurgent clinical significance.

The reports of the AVMA and the AAHA canine vaccine task force have listed these three vaccines as not generally recommended, because «the diseases are either of little clinical significance or respond readily to treatment», evidence for efficacy of these vaccines is minimal, and they may «produce adverse events with limited benefit».

It is not uncommon to see evidence of intervertebral disc degeneration with varying degrees of extrusion or protrusion, however the degree of epidural fat and cerebrospinal fluid attenuation can be evaluated to determine the likely clinical significance of these lesions.

To clarify clinical significance, we also examined the proportion of youth scoring in the severe range (CES - D score ≥ 24).

In this study by Cornelius et al, the reduction in Ham - D - 24 score in the fluoxetine group after detoxification and washout from 19 to 13, compared with 18 to 16 in the placebo group, would have added clinical significance if this reduction was associated with a concomitant reduction in current suicidal ideation.

We estimated clinical significance using change ratios and between - group effect sizes (g).

Following clinical significance guidelines (Jacobson et al. 1984), there was a reduction of 14 % in the intervention condition of children who scored above the 90th percentile of conduct problems (24 % at pretest, 10 % at posttest), relative to a reduction of 6 % in the control condition (23 % at pretest, 17 % at posttest).

Correlations between FR - EXT and perceived parenting styles were absent or very low and were without clinical significance.

The CARES module was designed to be delivered to children between the ages of 3.5 and 8 years with non-normative levels of CU traits immediately after completion of parent management training, and when CP have been reduced to below clinical significance.

While the difference in WOMAC improvement for participants receiving combined exercise therapy and manual therapy in addition to usual care did not meet the a priori threshold for clinical significance (28 points), there was a trend towards benefit, with this group improving 26.2 WOMAC points more than usual care only.

With great clinical significance, this miRNA - like fragment was detectable in EVD patients before development of viremia with detectable Ebola genomic RNA, suggesting that it is an earlier biomarker than genomic RNA and could advance diagnosable window for EVD.

The thyroid gland converts the amino acid tyrosine into thyroglobulin, and attaches one to four iodine atoms to create T4 (thyroxine), the inactive storage hormone, T3 (triidothyronine), or metabolically active thyroid hormone, and two thyroid hormones whose clinical significance is less known, T2 and T1.

Research on psychosocial adjustment of children with IBD suggests that they may be at risk for more difficulty than healthy children, but average scores on measures such as the Child Behavior Checklist (CBCL; Achenbach, 1991) do not reach clinical significance.

Collectively, it appears that this class of compounds might yield potent GABA active agents with clinical significance.

Similarly, the unadjusted difference of 8 points between children who were breast fed for less than 3 months, compared to those who were breast fed for six months or more, is unlikely to have clinical significance in a population with a mean IQ at age 5 of 109 points.

Clinical significance of low forced expiratory flow between 25 % and 75 % of vital capacity following treated pulmonary tuberculosis: a cross-sectional study

Mental health problems don't need to rise to the level of clinical significance to detract from high quality leadership, but the negative effects would likely be worse if we were considering clinical diagnoses of depression, anxiety, sleep problems or narcissism.

Babies break down alcohol more slowly than adults do, but since they consume so little alcohol from breast milk in the first place, this difference «should have no clinical significance,» researchers concluded in a recent research review on the topic.

The small differences in IQ points between breast fed and bottle fed children, 21 and between children breast fed for less than five months or more than five months, 10 are unlikely to have clinical significance.

The clinical significance of this study is, that the decrease in body mass and increase in walking speed achieved safely with aquatic resistance training are both large enough to prevention worsening of clinical symptoms and slow or even stop the loss of cartilage which are typical finding in late - stage knee osteoarthritis.