These ideas are summarized in a new paper, «Neuropsychiatric
Signs and Symptoms
of Alzheimer's Disease: New Treatment Paradigms,» published in the journal Alzheimer's &
Dementia: Translational Research &
Clinical Interventions.
Clinically affected dogs are often young (3 - 18 months
of age) and present with poor weight gain, progressive peripheral neuropathy including ataxia, leg crossing, tremors and paresis which worsens with exercise.Behavioral changes, blindness,
dementia, anorexia, cachexia, urinary incontinence and muscle weakness affecting all four limbs are usually present in terminal stages
of the disease with death occurring 2 - 6 months after onset
of clinical signs, necessitating euthanasia.