Sentences with phrase «clinical studies evaluating»

The major part of clinical studies evaluating the efficacy of probiotics in veterinary patients relates to the gastrointestinal system, particularly diarrhea cases.

A search of Pubmed [a data base containing all medical journal articles] for platelet rich plasma yields 6,811 articles, but less than 20 are clinical studies evaluating patient outcomes for orthopedic sports medicine conditions.

Techniques Functional imaging of the interaction between gut microbiota and the human host: A proof - of - concept clinical study evaluating novel use for 18F - FDG PET - CT.

Not exact matches

Researchers in the Mid-Atlantic Mental Illness Research, Education and Clinical Center at the W.G. (Bill) Hefner Veterans Affairs Medical Center in Salisbury, N.C., evaluated 45 U.S. veterans who volunteered to participate in the study.

«Complex models are needed to effectively evaluate PMed study designs, and this proof - of - concept trial validates the dog with cancer as a model for clinical evaluation of novel PMed approaches,» said Dr. Melissa Paoloni, the study's lead author and former director of the COTC.

As it matures, the authors wrote, it is moving «from laboratory - based experimental studies in model systems to a mature discipline that is yielding products that are being evaluated and used in the clinical domain.

The discovery of an unexpected biochemical link within tumor cells should lead to clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated in human studies, the researchers said.

Of the 10 patients enrolled in the study — a clinical trial designed to evaluate safety and feasibility — none of the participants experienced any dangerous side effects and one patient's disease remained stable after 18 months.

«The idea behind this study was to re-evaluate the bar that was previously established for evaluating a person's immune response to influenza vaccines,» said the study's principal investigator Matthew J. Memoli, M.D., director of the Clinical Studies Unit in NIAID's Laboratory of Infectious Diseases.

The scientists next plan to evaluate the precise roles of the five genes and to validate the accuracy of their diagnostic assay in a prospective clinical study.

Researchers at The Royal Manchester Children's Hospital and The University of Manchester have recruited the first child into a new study, which aims to evaluate the clinical effectiveness of a treatment developed in Manchester.

Patients who go to the emergency room (ER) with chest pain often receive unnecessary tests to evaluate whether they are having a heart attack, a practice that provides no clinical benefit and adds hundreds of dollars in health - care costs, according to a new study from researchers at Washington University School of Medicine in St. Louis.

The data obtained from this study provide a basis for more rapid, cost - effective clinical trials to evaluate new influenza drugs or to determine the efficacy of candidate vaccines for both seasonal and pandemic influenza.

The study, published in the Journal of Clinical Oncology, evaluated 46,237 women who continued to attend annual multimodal screening following the first screen.

Dr. El Khoudary and her team evaluated clinical data, including blood samples and heart CT scans, on 456 women from Pittsburgh and Chicago enrolled in the Study of Women's Health Across the Nation (SWAN).

To evaluate the device, the research team collected and studied 350 clinical semen specimens at the MGH Fertility Center.

Case No. 18 states that a study in which a healthy volunteer undergoes MRI brain imaging while performing a working memory test is now a clinical trial because the effect being evaluated — brain function — is a health - related outcome.

The recent study, published in the journal Archives of Clinical Neuropsychology, focuses on using a simple test of visual flicker to evaluate an individual's level of executive cognitive abilities, such as shifting attention between different tasks, planning or organizing and problem solving.

40 RR - MS patients participated in this study, all of whom were receiving regular drug therapy and were being evaluated for disease progression through clinical examination.

They designed a pilot clinical study in IBS to evaluate the effect of a substance that blocks the histamine 1 receptor on the nerves, so that the sensitivity of TRPV1 no longer increases.

An HIV - 1 version of the promising vaccine regimen is now being evaluated in an ongoing Phase 1 / 2a international clinical study.

The USPSTF based its recommendations on a meta - analysis of 136 clinical trials, observational studies and a systematic review evaluating the effects of supplementation on fracture and cancer risk.

Based on these pre-clinical data, the HIV - 1 version of this vaccine regimen is now being evaluated in an ongoing Phase 1 / 2a international clinical study sponsored by Crucell Holland B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

The study, «A Multi-Center Clinical Trial to Evaluate the Effectiveness of Intermittent Hypoxia Therapy in Individuals with Spinal Cord Injury (SCI),» is being conducted by an experienced team of scientists and clinicians at three leading SCI rehabilitation institutions: Shirley Ryan AbilityLab (lead investigator, William Zev Rymer, MD, PhD), Kessler Foundation (Gail Forrest, PhD; Steven Kirshblum, MD), and the University of Miami (Monica A. Perez, PT, PhD).

SEATTLE, WA and DURHAM, NC — The HIV Vaccine Trials Network (HVTN) and the HIV Prevention Trials Network (HPTN) today announced the initiation of HVTN 704 / HPTN 085, also known as Antibody Mediated Prevention (AMP) or the AMP Study, a Phase 2b clinical trial to evaluate the safety and efficacy of VRC01, a broadly neutralizing monoclonal antibody (bnAb).

A Phase 1b / 2 Open - Label Study to Evaluate Safety, Clinical Activity, Pharmacokinetics and Pharmacodynamics of Avelumab (MSB0010718C) in Combination with Other Cancer Immunotherapies in Patients with Advanced Malignancies

Ultimately, this will provide for current and future studies such as those that evaluate the correlation of biological markers with clinical variables and cancer outcomes, as well as those that identify interactions among biological markers.

The Biomarkers for Spinal Muscular Atrophy (BforSMA) clinical trial is a current pilot study looking to identify potential biomarkers (measures) that can be used to evaluate SMA disease severity and future treatments.

«Investigational» means that the drug is still being evaluated in clinical studies, and has not yet been approved for use by doctors in their everyday practice.

In the study, the researchers identified 44,144 patients enrolled in clinical trials evaluating hematologic malignancies submitted to the FDA in support of approval of new or supplemental indications from 2005 to 2015.

A clinical trial (or clinical research) is a research study to evaluate a new drug or treatment.

The first clinical trial was a safety study in Australia, followed by an ongoing efficacy study in Peru to evaluate the ability to treat patients with malaria.

This is the first study to evaluate the safety and clinical activity of the combination of oral pazopanib, intravenous or oral irinotecan, and oral temozolomide in pediatric and young adult patients with relapsed or refractory sarcomas.

The results from this cohort will help us evaluate what is the optimal dose for a future, larger clinical study.

In the largest analysis of PD - 1 blockade in mucosal melanoma to date, patients treated in clinical studies with either nivolumab monotherapy or nivolumab combined with ipilimumab were evaluated in a pooled analysis.

Research You will have access to appropriate clinical studies to evaluate new methods for the early detection of cancer, cancer prevention, cancer treatment, and genetic testing.

Paris, France, April 3, 2018, 5.35 pm CET — GenSight Biologics (Euronext: SIGHT, ISIN: FR0013183985, PEA - PME eligible), a biopharma company focused on discovering and developing innovative gene therapies for retinal neurodegenerative diseases and central nervous system disorders, today announced topline results from the REVERSE Phase III clinical trial evaluating the safety and efficacy of a single intravitreal injection of GS010 (rAAV2 / 2 - ND 4) in 37 subjects whose visual loss due to 11778 - ND4 Leber Hereditary Optic Neuropathy (LHON) commenced between 6 and 12 months prior to study treatment.

Evaluating the efficacy of repurposed small molecule inhibitors in treating filariasis using preclinical and clinical studies

Together, our data suggest that clinical studies may be warranted to evaluate the therapeutic potential of ABL allosteric inhibitors and to determine whether combination therapies that incorporate these compounds are effective in treating metastatic breast cancer.

Our group focuses on developing pharmaceutical and immunological strategies to reduce HIV - 1 persistence, and on evaluating such interventions in clinical studies.

The RETAIN Study is a clinical research study evaluating a protein called alpha - 1 antitrypsin (AAT) in recently diagnosed type 1 diabetes patiStudy is a clinical research study evaluating a protein called alpha - 1 antitrypsin (AAT) in recently diagnosed type 1 diabetes patistudy evaluating a protein called alpha - 1 antitrypsin (AAT) in recently diagnosed type 1 diabetes patients.

This recommendation was rooted in an earlier observation by Williams et al, 19 based on both priority scores and funding rates, that clinical grant applications do not fare as well in the review process when evaluated by study sections reviewing relatively few clinical applications.

However, when 50 children were evaluated with the Autism Diagnostic Interview — Revised 35 and the Autism Diagnostic Observation Schedule — Generic, 36 94 % met criteria for ASD on both instruments, and 100 % met criteria on at least 1 instrument.37 Record - review validation studies conducted by the investigators demonstrate that the predictors of valid ASD diagnoses were having more than 2 diagnoses in the medical record.38 Most influenza infections in our study were determined from International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic codes rather than serologic evidence.

Armed with this knowledge, and the results of an initial feasibility study, the Dream Team will conduct a clinical trial to evaluate if personalized therapy, based on the genetic profile of each individual patient's cancer, improves outcomes.

Recently, Dr. Wapner led a multicenter study evaluating the accuracy, efficacy, and clinical advantages of prenatal diagnosis using microarray analysis.

In 1996, in response to these concerns, Varmus, then director of NIH, impaneled a group of experienced clinical investigators and academic health center administrators to make recommendations that might guide the NIH toward policy changes to alleviate the concerns in the clinical research community.14 Several of the panel's recommendations have been implemented, including increased support of the General Clinical Research Center budget, expanded support of training in clinical research, and the establishment of NIH - sponsored educational debt relief programs for clinical investigators.15 - 18 The panel also recommended restructuring of NIH peer review groups so that patient - oriented grant applications would be evaluated by study sections in which at least half the grant applications involve patient - oriented rclinical investigators and academic health center administrators to make recommendations that might guide the NIH toward policy changes to alleviate the concerns in the clinical research community.14 Several of the panel's recommendations have been implemented, including increased support of the General Clinical Research Center budget, expanded support of training in clinical research, and the establishment of NIH - sponsored educational debt relief programs for clinical investigators.15 - 18 The panel also recommended restructuring of NIH peer review groups so that patient - oriented grant applications would be evaluated by study sections in which at least half the grant applications involve patient - oriented rclinical research community.14 Several of the panel's recommendations have been implemented, including increased support of the General Clinical Research Center budget, expanded support of training in clinical research, and the establishment of NIH - sponsored educational debt relief programs for clinical investigators.15 - 18 The panel also recommended restructuring of NIH peer review groups so that patient - oriented grant applications would be evaluated by study sections in which at least half the grant applications involve patient - oriented rClinical Research Center budget, expanded support of training in clinical research, and the establishment of NIH - sponsored educational debt relief programs for clinical investigators.15 - 18 The panel also recommended restructuring of NIH peer review groups so that patient - oriented grant applications would be evaluated by study sections in which at least half the grant applications involve patient - oriented rclinical research, and the establishment of NIH - sponsored educational debt relief programs for clinical investigators.15 - 18 The panel also recommended restructuring of NIH peer review groups so that patient - oriented grant applications would be evaluated by study sections in which at least half the grant applications involve patient - oriented rclinical investigators.15 - 18 The panel also recommended restructuring of NIH peer review groups so that patient - oriented grant applications would be evaluated by study sections in which at least half the grant applications involve patient - oriented research.

Priority will be given to studies that evaluate combinations of agents that induce immune deviation and / or regulation, produce effector cell depletion or exhaustion, to achieve durable clinical remission of disease.

«This study allowed us to evaluate the protective efficacy of several prime - boost vaccine combinations, and these data will help guide the advancement of the most promising candidates into clinical trials,» noted lead author Dr. Dan Barouch of Beth Israel Deaconess Medical Center at Harvard Medical School and the Ragon Institute of MGH, MIT, and Harvard.

The purpose of this study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG - 120 in advanced hematologic malignancies that harbor an IDH1 mutation.

The Parkinson's Progression Markers Initiative (PPMI) is a landmark observational clinical study to comprehensively evaluate cohorts of significant interest using advanced imaging, biologic sampling and clinical and behavioral assessments to identify biomarkers of Parkinson's disease progression.