Sentences with phrase «clinical subset of patients»
The physical findings in persons meeting the Canadian definition may signal the presence of a neurologic condition considered exclusionary for CFS and thus the XMRV positive persons in the Lombardi et al. study may represent a clinical subset of patients [11].
https://retrovirology.biomedcentral.com/ Not exact matches
The result is a genomically defined subset of patients with a clear likelihood of clinical improvement.
Cancer immunotherapy can produce durable clinical responses, but only in a subset of patients.
This study involved a subset of patients enrolled in a clinical trial of pediatric AML called AML02.
A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients.
«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»
In a randomized, phase 2 multi-center clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutations.
Yet research and clinical observations over the past 40 years have raised concerns that these drugs produce suicidal thoughts, suicide attempts and possibly even suicide in a small subset of depressed patients.
The study enrolled 100 patients with de novo coronary lesions 2.25 - 3.50 mm in diameter and length ≤ 27 mm in two 50 - patient cohorts for angiographic, intravascular ultrasound, and clinical assessment at nine or 24 months, with optical coherence tomography (OCT) performed in a subset of 30 patients at multiple time periods.
The paper, «Perturbations in the lipid profile of individuals with newly diagnosed type 1 diabetes mellitus: lipidomics analysis of a Diabetes Antibody Standardization Program sample subset,» published in Clinical Biochemistry, described lipidomics (see sidebar) analyses of blood samples from patients recently diagnosed with type 1 diabetes mellitus (T1DM).
Overall, despite the dramatic therapeutic advances made elsewhere in the melanoma field, the poor prognosis of patients with mucosal melanoma mandates continued emphasis on laboratory and clinical research efforts in this rare subset of disease.
[44] Two other phase II clinical trials evaluated the efficacy of imatinib in patients with melanoma — including mucosal melanomas — harboring KIT mutations and / or amplifications, with a subset of cases involving mucosal primaries, and both found a disease control rate of approximately 50 %.
The third paper in the issue of the Journal of Clinical Oncology describes an analysis of a very rare subset of patients with low - stage disease and amplification of the MYCN oncogene.
Within the subset of 23 patients that were in the higher dose cohorts and would qualify for the Toca 5 trial, patients had a median survival of 14.4 months and 43.5 % (10/23) of patients had clinical benefit (5 complete responses and 5 stable disease patients).
All of the case series studies showed improvements in clinical measures, which indicates that these outcomes can be obtained in the outpatient practice setting in at least a subset of adherent patients.
In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.
The subset of clinical neuropsychology applies this knowledge to help in the assessment, diagnosis, and treatment of patients that have cognitive disorders, learning disabilities, neurological or psychiatric conditions, and physical or developmental issues that have cognitive or mental repercussions.