Sentences with phrase «clinical trial design»

This type of trial is considered the pinnacle of clinical trial design.

A larger clinical trial designed to do just that will begin recruiting subjects later this year.

Phase I trial - an early clinical trial designed to study an experimental vaccine in humans.

We have numerous ongoing clinical trials designed to evaluate our drugs in a variety of health conditions.

Everybody has to agree what is a reasonable clinical trial design.

All previous clinical trials designed to reduce the levels of amyloid - beta using one therapy at a time have had limited success.

Additionally, the authors emphasize the potential predictive selection criteria for novel treatment strategies and refined clinical trial design.

It will house 150 researchers and clinician scientists, as well as an additional 100 people working in clinical trial design and administration.

The placebo effect «was regarded for many, many years as just a nuisance variable, something you had to take into account to find out about something else,» says Harvard University psychologist Irving Kirsch, who has studied placebos and clinical trial design for decades.

Identifying the molecular causes of disease represented a major breakthrough in the history of medicine, moving the discipline from pattern recognition and therapeutic strategies based on syndromic pathophysiology to molecular mechanism and evidence ‐ based therapies derived from clinical trials designed on the basis of molecular mechanism.

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

«The immediate thing to be done,» he adds, is to launch a new clinical trial designed not just to detect the association between NQO1 * and prognosis, but to really test the predictive power of NQO1 * 2 on cancer prognosis in women randomly assigned to epirubicin and other therapies.

«Veterinarians will have new, innovative therapies to offer clients, and insights gained in dogs and cats will help inform clinical trial design in humans.»

Johns Hopkins Bloomberg School of Public Health Statistical methods and automated software tool for stress - testing adaptive clinical trial designs

The BabySeq Project: Genomic Sequencing for Childhood Risk and Newborn Illness (U19 HD077671) is a first - of - its - kind randomized clinical trial designed to examine how best to use genomics in clinical pediatric medicine by creating and safely testing methods for integrating sequencing into the care of newborns.

«Essentially this would be analogous to human clinical trial design, but all on inexpensive chips,» Ingber says.

There's also substantial reason to believe he may have used his position to set up a meeting with the National Institutes of Health in November 2013 to ask that an NIH employee meet with Innate employees to discuss clinical trial designs, the panel found.

In this new study and for the first time, scientists used functional magnetic resonance imaging (fMRI) combined with a standard clinical trial design to derive an unbiased brain - based neurological marker to predict analgesia associated with placebo treatment in patients with chronic knee osteoarthritis pain.

In an interview in the spring of 2015, Damiano confidently predicted: «We're going to be running a pivotal trial by the end of the year,» referring to the type of clinical trial designed specifically to meet the FDA's standards for getting a device approved.

«We're doing a lot of work to improve clinical trial design and to improve the way drugs are discovered and developed,» Perlmutter says.

An example: Johnson uses Bayesian statistics, a statistical formalism that allows researchers to modify their hypotheses as data are collected, to tease out small differences in a therapy's effectiveness from clinical trials designed with the traditional accept - or - reject approach.

The FDA already has a 6 - year - old program called the Critical Path Initiative that, according to its Web site, funds a number of research projects on topics such as clinical trial design.

The original algorithm is now freely available upon request, but Origent hopes to market programs that can be tailored to specific clinical trial designs or even used to help doctors make more personalized predictions for their patients.

Learn about the FAMHL clinical trial designed to pinpoint genetic causes.

The ECCO - AACR - EORTC - ESMO Workshop on Methods in Clinical Cancer Research is an educational programme that introduces junior clinical oncologists in any oncology subspecialty to the principles of good clinical trial design.

Through clinical trials designed to scientifically determine the efficacy of conceptually designed treatments capitalizing on recent research on reading comprehension, language, and self - regulation, we hope to increase the overall impact of intervention on reading comprehension outcomes for students.

Accountable for overall management of the company cardiac clinical trials designed to bring unique annuloplasty rings to market.

In addition, she is the director of a federally - funded clinical trial designed to test the efficacy of an intensive intervention for panic disorder in adolescents, and to assess whether the direct involvement of parents in the intervention improves treatment effectiveness.

In just the last 6 years the EID outbreaks of MERS, Ebola, Zika, CHIKV as examples have underscored the importance of rapid vaccine development and deployment capabilities to meet EID challenges, as well as growing appreciation for creativity and flexibility in clinical trial design.

The team's understanding of industry best practices is derived from an extensive collection of case studies documenting the impact of clinical trial design, partnership structures, public market dynamics, and many other factors on valuation and business viability.

NIH's request for proposals lists examples ranging from new clinical trial designs to tools for detecting microbial contamination in products.

iTeos» competitive edge is in the combination of expertise in drug discovery, translational tumour immunology and early clinical trial design.

The CBER is already utilizing in silico techniques to predict clinical outcomes and product safety, inform clinical trial designs, and optimize dosing, and is also implementing the Regenerative Medicine Advanced Therapy (RMAT) designation which provides resources to expedite promising regenerative medicines that address unmet needs.

«Today we have a plethora of innovative and creative opportunities that range from early detection, biomarker discoveries and adaptive clinical trial designs,» says Baladandayuthapani.

As one of the of the center's research projects, Dr. Kent P. Hymel, a child abuse pediatrician at Penn State Children's Hospital, will lead eight pediatric intensive care units from across the country in a randomized clinical trial designed to assess the impact of a novel screening tool for pediatric abusive head trauma.

This study was the first large clinical trial designed to evaluate clinical outcomes in STEMI patients, as opposed to surrogate endpoints such as ST - segment resolution, Engstrøm said.

Of the 10 patients enrolled in the study — a clinical trial designed to evaluate safety and feasibility — none of the participants experienced any dangerous side effects and one patient's disease remained stable after 18 months.

Those clinical trial failures have already led to newer outcome and assessment tools supported by the National Institutes of Health, but these and other improved measures need to be more rapidly applied to clinical trial design to serve as markers of success or failure of fragile X-specific drug trials, says Budimirovic.

«Clinical trial designs that test such novel and potentially dangerous biologic therapies should only treat one patient at a time, followed by a reasonable period of time so that adverse events can be monitored,» he says.

The study, published in the Journal of Infectious Diseases, represents an important paradigm shift for HIV prevention strategies and could have major implications for clinical trial designs, said Angela Kashuba, Pharm.D., senior author of the study and the John and Deborah McNeill Distinguished Professor at the UNC Eshelman School of Pharmacy.

His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the tumor suppressor gene p53 is mutated.

Those projects have provided novel approaches to clinical trial design and the development of potential new therapies.

Additionally, CSCs could provide clues about the novel stem cell pathways activated during cancer progression, which, in turn, could guide further therapeutic steps and clinical trials design.