Sentences with phrase «clinical trials in human patients»

«Our eventual goal is a clinical trial in human patients.»

Not exact matches

A clinical trial to evaluate whether the ointment can treat antibiotic resistant infections in human patients is scheduled for 2018.

GTC recognized the need to demonstrate on its own the potential for the technology and, in the late 1990s, began a clinical trial of human antithrombin for patients undergoing bypass surgery who develop resistance to the anticoagulant drug heparin.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

In clinical human trials, patients wearing the Argus II implant were able to make out doorways, distinguish eight different colors, or read short sentences written in large letterIn clinical human trials, patients wearing the Argus II implant were able to make out doorways, distinguish eight different colors, or read short sentences written in large letterin large letters.

«However, given that IGF - 1 is approved for human use in people who are deficient in this hormone, a clinical trial of IGF - 1 in lithium - resistant bipolar disorder patients is warranted.»

Clinical trials have shown that injection of human umbilical stem cells, or hUTC, into the retina helps preserve and restore vision in macular degeneration patients.

More recently, HCQ has shown promise in treating pancreatic cancer patients in ongoing clinical trials; however, its tolerability and effectiveness to stop autophagy in humans with other cancers has not been shown before.

2015 will see the start of the first human clinical trial of a gene silencing or huntingtin - lowering drug, which specifically aims to reduce production of mutant huntingtin in the brains of HD patients.

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

While more research is needed to determine whether these approaches could help PD patients, Dr. Greenamyre is optimistic that one or both may ultimately make it into human clinical trials in an effort to slow or halt the otherwise inevitable progression of PD.

«Once we've shown that this can safely be used in human patients with pulmonary hypertension — and we've got a clinical trial in progress right now — we'll be able to conduct studies of inhaled NO delivered in ambulatory settings, including patients» homes, to treat chronic pulmonary hypertension, right - sided heart failure and chronic obstructive pulmonary disease.»

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

The next steps will be to replicate these results and then eventually test the method in clinical trials with human patients.

In order to formally introduce this treatment to modern dentistry, however, the researchers will need to perform clinical trials with human patients.

More animal studies would be needed to move this drug toward human clinical trials, but «what we hope is that we could use this drug to intervene in patients who have had an episode of prolonged seizures and give it to them briefly following that episode to protect them from becoming epileptic,» said James McNamara, M.D., a professor in the departments of neurobiology and neurology at Duke University.

Despite encouraging evidence from animal studies that it clears amyloid from the brain, when it came to clinical improvements in human patients the drug proved no better than placebo in two phase III clinical trials.

A clinical trial in humans of a vaccine based on Ab antibodies was halted in 2002 because 5 percent of the patients developed encephalitis.

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioIn the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better visioin one eye have experienced no harmful side effects and appear to have slightly better vision.

«We just don't know how hESC therapies will behave in humans unless we actually administer them to patients in the course of a properly conducted clinical trial,» says Mason.

Past clinical trials of stem cell therapies for chronic stroke patients used cells derived from tumors in humans and brain tissue from fetal pigs.

«This is the first human trial of this novel stem cell - based implant, which is designed to replace a single - cell layer that degenerates in patients with dry age - related macular degeneration,» says lead author and surgeon for the study Dr. Amir H. Kashani, assistant professor of clinical ophthalmology at the Keck School of Medicine of USC.

In order to most rapidly realize the value of genetics for human health, deCODE is currently partnering with life sciences companies to accelerate their target discovery, validation, and prioritization efforts, yielding improved patient stratification for clinical trials and essential companion diagnostics.

Geron became the first company to start clinical trials of embryonic stem cells in humans, starting with a patient who had spinal cord injuries.

Dr. Srivastava has co-founded a biotechnology company to help find new cures for many human diseases and one of the developmental genes whose role he discovered, Thymosin β4, is currently in clinical trials for patients suffering ischemic damage to the heart.

The researchers now plan to tweak the nanoparticles for direct use in human patients, working to evaluate the safety of the method prior to potential clinical trials.

All six patients suffered from end - stage heart disease and were enrolled in this first - in - human (FIH) clinical trial, approved by the U.S. Food and Drug Administration in late 2015.

NGF is in fact viewed as a viable target for AD clinical trials with one group investigating NGF ex vivo gene delivery in a Phase 1 trial with human patients aimed at stimulating cholinergic function and improving memory [123].

Concerns about immunological consequences of rAAV - mediated gene transfer were substantiated by the outcome of a clinical trial in which human hemophilia B patients were infused into the liver with rAAV -2-F.

The aim of this clinical trial is to replicate in humans the same results observed in mice and, ultimately, lead to an effective, nontoxic treatment for newly diagnosed patients as well as patients who can no longer benefit from conventional treatments.

Therapies applying this paradigm to clear β - amyloid protein (Aβ) plaques and soluble aggregates from patients with Alzheimer's disease (AD) is an extremely active field of research, with multiple active and passive Aβ vaccines currently in human clinical trials.

Since human pancreatic cancer has certain immunological characteristics of the mouse model, a phase 1 clinical trial of AMD3100 in patients with pancreatic cancer will be initiated in 2015.

A phase - 1 clinical trial of the drug in human patients with pulmonary hypertension is expected to begin this winter.

In Louisiana, the 4 - year - old TCA Cellular Therapy company has several ongoing FDA - approved clinical trials on humans, using patients» own stem cells to treat heart and vascular diseases.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissuIn a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanclinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissuin large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanClinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanclinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified humanclinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.

Several clinical trials, including this one led by Emoryâ $ ™ s Nicole Turgeon, have shown that islets isolated from deceased human donors can restore normal blood sugar regulation in patients with type 1 diabetes.

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

As we produce more human - relevant data with our Organ - Chips, we look forward to making a positive impact on informing R&D decisions, reducing drug candidate attrition in human clinical trials, and helping to deliver better and safer medicines to patients.»

And, indeed, small clinical trials in humans have shown patients report less fatigue and fewer gastrointestinal symptoms while fasting during chemotherapy treatments.

Conduct clinical trials in a petri dish using the actual affected human cell types — from patients rather than from surrogate models (e.g. animals).

A veterinary clinical trial is a study conducted on veterinary patients and focused on evaluating the effects of new therapies, medical devices and diagnostic tests for eventual use in veterinary or human medicine.

Currently, it is being investigated as an immune system supplement in human cancer patients in a Food and Drug Administration (FDA) sanctioned clinical trial.

Vetmed.tamu.edu: «Research Offers Hope for Spinal Cord Injuries: How a Clinical Trial in Dogs May Help Human Patients.»