Sentences with phrase «clinical trials in humans with»

In fact, our work has already led to clinical trials in humans with TCC.

In 2008, a landmark clinical trial in humans with severe cognitive decline was conducted to measure the effects of curcumin.

Not exact matches

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

Now that they've demonstrated the significance of insulin signaling in the human mammary gland, they are planning a phase I / II clinical trial with a drug used to control blood sugar in type 2 diabetes to determine whether it improves insulin action in the mammary gland, thus improving milk supply.

The PhD course focuses on various aspects of human (donor) milk, with as main study a randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition Study).

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Once we have demonstrated the proof of concept in animal studies, the next goal will be to work towards the first human clinical trial with graphene devices during intraoperative mapping of the brain.

With proof of efficacy now published in monkeys and rabbits, preparations are being made for the first clinical trial in humans.

They will also work with Vir Biotechnology, Inc. of San Francisco, which has licensed aspects of their CMV - based vaccine approach, to expand testing with plans to start a human clinical trial in 2020.

«The findings reported are derived from an artificial in vitro experimental system and do not appear to be consistent with the data obtained by two independent groups utilising samples from the human clinical trials of the actual Merck Ad5 HIV vaccine.»

Most are already being tinkered with in animal models, and at least four have reached clinical trials in humans.

Working with the laboratory of Jeffrey Winkler, PhD, the Merriam Professor of Chemistry at the University of Pennsylvania, the team now hopes to develop optimized activators — or «agonists» — of the GPER and PAQR7 receptors, for eventual testing in human clinical trials.

On its own, DON has shrunk tumors in clinical trials of people with a variety of advanced cancers, but its damage to the gastrointestinal system, a glutton for glutamine, ultimately proved too toxic for humans, say the scientists.

More recently, HCQ has shown promise in treating pancreatic cancer patients in ongoing clinical trials; however, its tolerability and effectiveness to stop autophagy in humans with other cancers has not been shown before.

The particles have been tested with human blood, but have not undergone clinical trials in humans.

Before they begin clinical trials in humans, however, the team says they plan to explore how the medication may work in monkeys infected with the measles virus.

«Once we've shown that this can safely be used in human patients with pulmonary hypertension — and we've got a clinical trial in progress right now — we'll be able to conduct studies of inhaled NO delivered in ambulatory settings, including patients» homes, to treat chronic pulmonary hypertension, right - sided heart failure and chronic obstructive pulmonary disease.»

For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have weak immune systems.

Clinical trials in dogs are similar to those done in humans, with safety protections in place to minimize harm.

In human clinical trials with Euclidean - based devices, visual acuity has only achieved 20/1260 for implants placed in front of the retinIn human clinical trials with Euclidean - based devices, visual acuity has only achieved 20/1260 for implants placed in front of the retinin front of the retina.

The next steps will be to replicate these results and then eventually test the method in clinical trials with human patients.

An accelerated progression may show up in clinical trials in human males, who live longer with the disease than mice.

In order to formally introduce this treatment to modern dentistry, however, the researchers will need to perform clinical trials with human patients.

«These high - performing BCI algorithms» use in human clinical trials demonstrates the potential for this class of technology to restore communication to people with paralysis,» said Nuyujukian.

«With the long - awaited federal passage of GINA, researchers and clinicians can now actively encourage Americans to participate in clinical trials without the fear of genetic discrimination,» said Joann Boughman, executive vice president of the American Society of Human Genetics (ASHG).

This study was designed to use readily available agents in an accepted large - animal model of human heart attack with the goal of obtaining evidence that this treatment is ready to be moved into human clinical trials.»

Clinical trials evaluating the safety of enzyme - converted blood in humans are already under way, with initial results expected later this year.

Now there is a need for clinical trials with humans in order to verify its safety as an adjuvant in the treatment of leishmaniasis.

Nearly 70 percent of the postmenopausal women in their overall analysis — a total of 36,282 individuals 50 to 79 years of age — were part of a large 2006 clinical trial supported by the National Institutes of Health and the Department of Health and Human Services called the Women's Health Initiative, which assessed the effects of supplementing with 1,000 milligrams of calcium and 400 IUs of vitamin D per day for an average of seven years.

With miglustat therapy available off - label in the U.S. and potential therapies in clinical trials, the researchers said their goal is to see the test added to the recommended uniform screening panel defined by the U.S. Department of Health and Human Services (HHS).

Clinical trials for several vaccines are in various phases, with promising published results in humans.

«This is the first human trial of this novel stem cell - based implant, which is designed to replace a single - cell layer that degenerates in patients with dry age - related macular degeneration,» says lead author and surgeon for the study Dr. Amir H. Kashani, assistant professor of clinical ophthalmology at the Keck School of Medicine of USC.

In order to most rapidly realize the value of genetics for human health, deCODE is currently partnering with life sciences companies to accelerate their target discovery, validation, and prioritization efforts, yielding improved patient stratification for clinical trials and essential companion diagnostics.

Geron became the first company to start clinical trials of embryonic stem cells in humans, starting with a patient who had spinal cord injuries.

Humans have a homologous population with nearly identical specificity, and although the cells tend to be more frequent in mice than humans, clinical trials are underway based on activating human iNKT cells to stimulate antitumor respHumans have a homologous population with nearly identical specificity, and although the cells tend to be more frequent in mice than humans, clinical trials are underway based on activating human iNKT cells to stimulate antitumor resphumans, clinical trials are underway based on activating human iNKT cells to stimulate antitumor responses.

In 1999, Wolchok received a grant from CRI to conduct a clinical trial of a xenogenic vaccine in humans with melanomIn 1999, Wolchok received a grant from CRI to conduct a clinical trial of a xenogenic vaccine in humans with melanomin humans with melanoma.

Promote human clinical trials of repurposed drugs, in collaboration with medical centers (like UC San Francisco) and pharmaceutical companies in the US and abroad.

These results could pave the way for the use of progesterone against glioblastoma in a human clinical trial, perhaps in combination with standard - of - care therapeutic agents such as temozolomide.

«Remissions of Acute Myeloid Leukemia and Blastic Plasmacytoid Dendritic Cell Neoplasm Following Treatment with CD123 - Specific CAR T Cells: A First - in - Human Clinical Trial» is presented at the ASH Annual Meeting Dec. 9 to 12, 2017.

NGF is in fact viewed as a viable target for AD clinical trials with one group investigating NGF ex vivo gene delivery in a Phase 1 trial with human patients aimed at stimulating cholinergic function and improving memory [123].

This team plans to conduct the first human clinical trial combining these two therapeutic strategies (which have been tested separately and have shown activity in reducing HIV in humans), with the expectation that a boosted innate immune system empowered with unique antibodies to target HIV - infected cells will achieve greater reductions in HIV than observe previously.

Establishing a human clinical trial with specialists at Columbia University Medical Center in New York.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201in 2019.

Concerns about immunological consequences of rAAV - mediated gene transfer were substantiated by the outcome of a clinical trial in which human hemophilia B patients were infused into the liver with rAAV -2-F.

Therapies applying this paradigm to clear β - amyloid protein (Aβ) plaques and soluble aggregates from patients with Alzheimer's disease (AD) is an extremely active field of research, with multiple active and passive Aβ vaccines currently in human clinical trials.

Since human pancreatic cancer has certain immunological characteristics of the mouse model, a phase 1 clinical trial of AMD3100 in patients with pancreatic cancer will be initiated in 2015.

A phase - 1 clinical trial of the drug in human patients with pulmonary hypertension is expected to begin this winter.

A University of California at Los Angeles (UCLA) study headed by Antoni Ribas, M.D., Ph.D., is a first - in - human phase I clinical trial combining adoptive cell transfer of a T cell receptor engineered to recognize NY - ESO - 1 along with Yervoy ® (ipilimumab, anti-CTLA-4).

Currently, 31 tyrosine kinase inhibitors are FDA approved for human therapy, with many more in clinical trials.