Sentences with phrase «clinical use of stem cells»

«The Department of Health and its Gene Therapy Advisory Committee are currently working with other regulators in the field to produce a «Regulatory Route Map» to provide further clarity on the regulatory requirements for the clinical use of stem cells.»

Writing in the Transplantation, the researchers from Johns Hopkins Medical Institutions warned clinical use of stem cells was still a long way off.

The ministry asked local health authorities to halt any unapproved clinical use of stem cells in their regions.

Not exact matches

This includes a stem cell research centre, a network of drug discovery institutes and a # 20 million global clinical development fund dedicated to supporting Phase I and II clinical trials; and a # 2 million collaboration between University of Cambridge and University College London that will use donated cells from people with Alzheimer's to test potential new treatments

Cord blood stem cells can be used to treat dozens of diseases and are being tested in FDA - regulated clinical trials to help people with autism, brain injury, and other conditions.

In addition, where cells derived from embryonic stem cells are great at proliferating — a potentially critical feature if one wants to grow sufficient numbers of cells for clinical use — ones from the iPS lines were much feebler.

Then, a team led by Robert Lanza, the chief scientific officer of Advanced Cell Technology Inc. in Marlborough, Massachusetts, and his colleagues published the first results ever of a clinical trial using human embryonic stem cells.

«We used the algorithms to identify typical molecular signatures of stem cells [stemness signatures] that could help us understand tumors and serve as predictors of aggressiveness or clinical outcome.»

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tristem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical triStem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical trials.

When isolated, 99 percent of stem cells die, making it prohibitively difficult to manipulate their genes or expand their numbers for clinical use.

An attempt by the Chinese health ministry to enforce a ban on the clinical use of unapproved stem - cell treatments has had little effect

Using tumor samples from the Women's Healthy Eating and Living clinical trial, researchers identified stem - like tumor cells as being characterized by low levels of the molecule p53 upregulated modulator of apoptosis (PUMA).

Despite a lack of rigorous clinical trials to test safety or efficacy, a ban of the treatment by health authorities, and a lack of peer review by the scientific community, the privately funded Stamina Foundation has been using cultured mesenchymal stem cells that have been exposed to putative conditions that favour neuronal differentiation to treat different diseases in severely or terminally ill patients.

«This shows not only that the use of stem cell research in the clinical treatment of childlessness is unrealistic but also that clinics should focus on using the eggs that women have had since birth in treating infertility,» says Professor Kui Liu.

They also summarise the outcome of clinical trials that have investigated the use of mesenchymal stem cells in the treatment of a number of inflammatory, degenerative and immune - mediated diseases of cats.

Lanza previously led a clinical trial in the United States — published November 2014 in the Lancet — that demonstrated embryonic stem cells could be used safely for patients with degenerative eye diseases, but the patient sample was Caucasian with the exception of one African - American.

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

In fact, in an ongoing clinical trial that is transplanting cells derived from induced pluripotent stem cells (iPSCs), gene sequencing is used to ensure the transplanted cell products are free of dangerous mutations.

Three months after the Chinese health ministry ramped up its efforts to enforce a ban on the clinical use of unapproved stem - cell treatments, a Nature investigation reveals that businesses around the country are still charging patients thousands of dollars for these unproven therapies.

«These splicing signatures could potentially be used as clinical biomarkers to detect blood stem cells that show signs of early aging or leukemia, and to monitor patient responses to treatment,» said Crews.

Carol Gillis, a longtime veterinarian and researcher who specializes in soft - tissue injuries in racehorses, says that the more than 22,000 ultrasound images she has captured in her studies and clinical practice have convinced her that with a tightly regimented exercise program, tendons and ligaments will heal, producing strong, well - organized fibers — all without the use of stem cells.

This feature would be critical for clinical uses, such as transplanting stem cells — with their defects corrected — back into patients, but the researchers emphasize that years of further study remain before such treatments might be possible.

«This type of analysis is likely to become a gold standard for quality controlling stem cells, including induced pluripotent stem cells, whether they are to be used solely in research or envisioned for clinical applications,» he says.

This will mark the start of the first clinical trial in China using human embryonic stem (ES) cells, and the first one worldwide aimed at treating Parkinson's disease using ES cells from fertilized embryos.

Lorenz Studer, a stem - cell biologist at the Memorial Sloan Kettering Cancer Center in New York City who has spent years characterizing such neurons ahead of his own planned clinical trials, says that «support is not very strong» for the use of precursor cells.

The experiments will also represent the first clinical trials of ES cells under regulations that China adopted in 2015, in an attempt to ensure the ethical and safe use of stem cells in the clinic.

Fischer, in 2000, reported demonstrating the clinical efficacy of gene therapy for the first time, using blood stem cells to treat a fatal genetic disorder called X-linked severe combined immunodeficiency.

It has taken more than five years of graft, but at long last approval has been given for the first clinical trial using human embryonic stem cells (hESCs).

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better vision.

More than 40 clinical trials are underway using other kinds of stem cells, mainly bone marrow cells from the patients themselves.

Past clinical trials of stem cell therapies for chronic stroke patients used cells derived from tumors in humans and brain tissue from fetal pigs.

This allows embryonic stem cells to be employed as useful tools for both research and regenerative medicine, because they can produce limitless numbers of themselves for continued research or clinical use.

Paving the way for stem cell therapy, the first clinical trials using iPSCs was conducted by Masayo Takahashi, MD, PhD, of the RIKEN Centre for Developmental Biology in Japan.

Takashima K, Inoue Y, Tashiro S, Muto K. Lessons for reviewing clinical trials using induced pluripotent stem cells: examining the case of a first - in - human trial for age - related macular degeneration.

Her expertise includes optimization of standard operating procedures for cGMP manufacture of transgenic T cells, stem cells and dendritic cells to be used in clinical trials, planning and writing clinical trial protocols, IND (investigational new drug) applications and other regulatory documents.

Besides their clinical use, we are interested in the biology of hematapoietic stem cells in - vitro and in - vivo.

Clinical studies have assessed have assessed fetal tissues as a therapeutic treatment for HD [2 - 4], although these present with problems which may be overcome by the use of induced pluripotent stem cells (iPSCs)[5].

The first eight projects target clinical areas such as bone defects, salivary glands, and skin wounds using a variety of regenerative methods, such as stem cells, biomaterial scaffolding, and harnessing regenerative signal secretion.

To better understand the range of diseases being treated, I made a spreadsheet of all the clinical trials using adipose stem cells.

The birthday greeting contained an unintended irony, for while CIRM was approved by California voters a decade ago to give priority funding to human embryonic stem cell research, eight of the 10 approved clinical trials referenced by City of Hope were for research projects using adult and other non-embryonic stem cells.

To carry out pre-clinical testing of stem cell - derived mesDA and striatal GABAergic progenitors in rodent models of PD and HD with the goal to generate efficient and safe candidate cells for clinical use;

By my count, a total of 54 clinical trials using adipose stem cells have been registered with the clinicaltrials.gov database.

According to this excellent book on stem - cell biology, the volume of stem - cell research is now overwhelming, and the prospects for extended clinical use are great.

While breast reconstruction using adipose stem cells has gotten a lot of media attention because of Suzanne Somers» experience, there are adipose stem cell clinical trials ongoing for many diseases.

Based on positive results produced from a number of scientific clinical trials, coronary artery disease therapy using adult stem cells is a promising new method of treatment for coronary artery disease patients.

The South Florida Bone Marrow / Stem Cell Transplant Institute is now running a new clinical trial protocol (08001 - BMSCTI) for investigating a novel cancer therapy using transfusions of white blood cells from healthy donors.

Treating Spinal Cord Injuries: 2009 also saw the first FDA - approval of the use of human embryonic stem cells in a clinical trial.

Because the drug's mode of action was known and patients» response to treatment could be precisely monitored, Michor and colleagues used modeling methods and data from patients in a large clinical trial to identify a group of copiously self - renewing stem cells, which persist within the tumor, resist the drug, and sustain the cancer.

The website is a perfect complement to the «Stem Cells in Focus» blog, housing informational pages on basic stem cell biology, the process by which science becomes medicine, clinical trials and the use of stem cells in understanding and potentially treating specific health conditiStem Cells in Focus» blog, housing informational pages on basic stem cell biology, the process by which science becomes medicine, clinical trials and the use of stem cells in understanding and potentially treating specific health conditCells in Focus» blog, housing informational pages on basic stem cell biology, the process by which science becomes medicine, clinical trials and the use of stem cells in understanding and potentially treating specific health conditistem cell biology, the process by which science becomes medicine, clinical trials and the use of stem cells in understanding and potentially treating specific health conditistem cells in understanding and potentially treating specific health conditcells in understanding and potentially treating specific health conditions.

This type of research will lead to a better understanding of stem cell pluripotency and, ultimately, clinical use.