Sentences with phrase «clinically meaningful changes»

According to Jacobson and Truax, 39 statistically significant and large effect sizes do not necessarily translate into clinically meaningful changes (ie, an intervention effect may be statistically significant but clinically trivial).

Advanced melanoma patients successfully treated with a combination of nivolumab and ipilimumab may endure severe side effects, but they do not suffer any clinically meaningful changes in health - related quality of life.

But not surprisingly, there is a deficit between the understanding and working knowledge of data science, and how it can directly translate into clinically meaningful change.

Not exact matches

At week 5, statistically significant reductions in global health occurred in all arms, but the changes were not clinically meaningful.

In conclusion, Dr. Schadendorf said that «even though the nivolumab plus ipilimumab arm had a higher frequency of adverse events, no clinically meaningful health - related QoL changes from baseline were observed in any of the treatment arms.

To determine whether the intervention led to a clinically meaningful and reliable change the reliable change index was computed, as recommended by Jacobson and Truax.39 Because population norms for the GHQ - 12 and PSOC were not available for the present study population, we calculated the SE of difference (Sdiff) based on the pretest scores for the intervention and control group combined, assuming a measurement reliability of 0.8 for each measure.

Pre — post change scores showed significant improvements across all measures for the parents, with the percentage of parents with clinically meaningful impairments due to anxiety going from 20 % to approximately 7 % post-intervention; in depression from approximately 25 — 8 %; and in perceptions of unhealthy family functioning from over 50 % to approximately 30 %.