In general, of course, we want large effect sizes in our practice, and we want
clinically meaningful effects.
Not exact matches
If the average treatment
effect had not been
clinically meaningful, we would not have combined trials.
If the average treatment
effect was not
clinically meaningful, we would not combine trials.
As there was clinical heterogeneity sufficient to expect that the underlying treatment
effects differed between trials, or where substantial statistical heterogeneity was detected, we used random -
effects meta - analysis to produce an overall summary, if an average treatment
effect across trials was considered
clinically meaningful.
«The magnitude of the treatment
effect of FCM on the 6MWT distance, is robust and
clinically meaningful,» noted Professor Ponikowski.
Advanced melanoma patients successfully treated with a combination of nivolumab and ipilimumab may endure severe side
effects, but they do not suffer any
clinically meaningful changes in health - related quality of life.
Although the difference in patient mortality between male and female physicians was modest, an observed
effect size of a 0.43 - percentage point difference or a relative risk reduction of 4 % in mortality is arguably a
clinically meaningful difference.
It has a
clinically meaningful anxiolytic
effect and alleviates anxiety related disturbed sleep.»
Although the thermogenic
effect of CCRT has the potential to produce significant
effects on these metabolic targets as well as on fat absorption and energy intake, possibly via its impact on the gut microbiota and gene expression, a
clinically meaningful outcome also depends on compliance by the subjects.
According to Jacobson and Truax, 39 statistically significant and large
effect sizes do not necessarily translate into
clinically meaningful changes (ie, an intervention
effect may be statistically significant but
clinically trivial).
Effect sizes (ESs) were calculated for all trends and statistically significant findings; (ES ≈ 0.5 (d)-RRB- was considered
clinically meaningful.
The meta - analyses showed the most pronounced
effect sizes for parent — child interaction and maternal sensitivity, whereas the
effects on child behaviour and cognitive development were either small or not significant; however, small
effect sizes can have
meaningful impact on population - level outcomes.60 The non-significant outcomes for internalising and externalising behaviours were also small, but may be
clinically relevant for large, at - risk populations.
Intervention
effected significant and
clinically meaningful symptomatic amelioration in OCD, depression, and anxiety symptoms.