Sentences with phrase «clinically relevant studies»

The piglet models the anatomy and development of the nervous system of human infants well and provides a practical platform to perform these clinically relevant studies.

Not exact matches

According to the researchers, the study demonstrates that quantitative approaches from Physics can be used to address fundamental as well as clinically relevant issues in Biology.

Although the number of participants in the study was relatively small, the researchers report that it was sufficiently large to detect clinically relevant effects.

«Data from this study serves as rationale to now include dogs with spontaneous cancers in the advancement and optimization of PMed for human patients,» according to the study, Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.

«One of the broader goals of our research is to make regenerative treatments more accessible and clinically relevant by developing easy, efficient and cost - effective ways to engineer human cells and tissues,» said Shyni Varghese, a bioengineering professor at UC San Diego and senior author of the study.

«In this study, we identified an appreciable number of clinically relevant editing events, many of which are in non-coding regions.»

«Our study demonstrates that ANG regulates critical functions of both clinically - relevant cell types.»

«Prospective longitudinal studies like the one here... are able to provide reliable conclusions on such a clinically and highly relevant research question.

«If this turns out to be the truth, it's both biologically interesting and extremely clinically relevant,» says Gustaf Edgren, an expert who was not involved in the study but co-wrote an editorial about it.

The UI study showed that adding thermometer data, which captures clinically relevant symptoms (temperature) likely even before a person goes to the doctor, to simple forecasting models, improved predictions of flu activity.

Based on the results published in this paper, and with the aim to study the biology and epidemiology of Leishmania in a clinically more relevant context, Dr. Gerald Späth established the international consortium «LeiSHield», that coordinates a concerted effort between partner teams of the Institut Pasteur International Network and beyond, which was initially supported by a seeding fund from the Institut Pasteur International Direction, and is now funded by a 1.7 million euro grant from the EU H2020 program.

In the new study, the approach was applied to simulate and compare the potentially toxic liver effects of fifteen different drugs at clinically relevant doses.

«Nomograms offer the ability to personalize survival estimates for patients based upon a host of factors that are clinically relevant when we meet patients,» stated Carole Fakhry, MD, the study's lead author and an associate professor in the Department of Otolaryngology Head and Neck Surgery at John Hopkins University.

Depending on your field of Ph.D. study (in particular, whether it's in a clinically relevant field) you may qualify — eventually, after several years of postdoctoral training — for a K08 or K23 Career Development Award (see above).

The two primary outcomes in this study evaluating adjunctive brivaracetam in the treatment of partial - onset seizures in adults with epilepsy were statistically significant and clinically relevant,» said Dr. Pavel Klein, director, Mid-Atlantic Epilepsy and Sleep Center.

«Our findings are clinically relevant as they identify a novel addiction target in rodents, along with parallel supporting evidence from brain imaging studies in human addicts,» explains Andon Placzek, lead author of the nicotine study.

Based on the results published in this paper, and with the aim to study the biology and epidemiology of Leishmania in a clinically more relevant context, Dr. Gerald Späth established the international consortium «LeiSHield» (www.leishield.org), that coordinates a concerted effort between partner teams of the Institut Pasteur International Network and beyond, which was initially supported by a seeding fund from the Institut Pasteur International Direction, and is now funded by a 1.7 million euro grant from the EU H2020 program.

Evidence of interallelic complementation at clinically relevant loci is limited to biochemical and cell - based studies of a handful of metabolic disorders with defects in enzymes including propinyl - CoA carboxylase [2], argininosuccinate lyase [3], galactose -1-phosphate uridylyltransferase [4], and methylmalonyl CoA mutase [5].

Further, for each plasmid in the kit, the transcript most commonly found across all TCGA tumor samples is represented, making the results of any such study as clinically relevant as possible.

So when she launched her own lab as a 29 - year - old assistant professor at Harvard Medical School in 2008, she continued to study RNA — but with the clear goal of performing clinically relevant research.

Here we tested whether human NSCs could be reprogrammed into iPS cells utilizing a similar strategy as described above since they represent a more clinically relevant source of cells for basic studies and modeling human disease.

In the current study, published online in the journal Chemical Senses, they then applied that methodology to a more clinically relevant population — humans.

At the conclusion of the study there was «a significant and clinically relevant improvement of skin sebum content and moisture».

Critics have pointed out that studies this small lack sufficient statistical power to measure clinically relevant improvement.2, 3 Nevertheless, two of the three studies demonstrated that retreatment improved some patients» measures, such as fatigue and pain.

In our study, we were able to show that the interventions investigated in MS patients lead to a clinically relevant improvement in the quality of life measured by the Multiple Sclerosis Quality of Life questionnaire.

A pilot study showed that spraying 56 mg / day onto the skin provided a clinically relevant rise in the serum level of magnesium in the body after 2 weeks (13).

This study provides a foundation for future studies to investigate whether TMAO can be used as an independent predictor of heart disease risk and whether TMAO and carnitine status can be used as markers of clinically relevant metabolic changes, but it hardly provides us with a basis for believing that carnitine from fewer than a thousand steaks per day causes heart disease through its conversion to TMAO.

Objective: This review sought to identify rigorous, clinically relevant research studies that provide high - quality evidence that therapeutic fasting regimens are clinically beneficial to humans.

Design: A systematic review of the published literature through January 2015 was performed by using sensitive search strategies to identify randomized controlled clinical trials that evaluated the effects of fasting on either clinically relevant surrogate outcomes (e.g., weight, cholesterol) or actual clinical event endpoints [e.g., diabetes, coronary artery disease (CAD)-RSB- and any other studies that evaluated the effects of fasting on clinical event outcomes.

The reduced sensitivity to pain and improvement in quality of life measured in this study appear to be clinically relevant and a larger, double - blind study is warranted.

At least one study described no evidence of clinically relevant perioperative complications when sterilizing heartworm - positive dogs, and many high - quality, high - volume spay - neuter clinics and shelters regularly engage in this practice.

An ongoing investment is made in scientific studies to provide the most clinically relevant protocols and to validate an ever - expanding list of applications

A UK clinical study using whole - body barometric plethysmography reported that 89.9 % of French Bulldogs tested were affected by BOAS to some extent, with 53.9 % exhibiting clinically relevant disease [9].

The items sum to a total score of 100; however, each item is a relatively independent domain of measurement highly relevant to providing a detailed clinical picture when employed to compare clinically distinct groups or, in this study, the relationship to ACE survey scores.

Many of the scales demonstrated weak psychometrics in at least one of the following ways: (a) lack of psychometric data [i.e., reliability and / or validity; e.g., HFQ, MASC, PBS, Social Adjustment Scale - Self - Report (SAS - SR) and all perceived self - esteem and self - concept scales], (b) items that fall on more than one subscale (e.g., CBCL - 1991 version), (c) low alpha coefficients (e.g., below.60) for some subscales, which calls into question the utility of using these subscales in research and clinical work (e.g., HFQ, MMPI - A, CBCL - 1991 version, BASC, PSPCSAYC), (d) high correlations between subscales (e.g., PANAS - C), (e) lack of clarity regarding clinically - relevant cut - off scores, yielding high false positive and false negative rates (e.g., CES - D, CDI) and an inability to distinguish between minor (i.e., subclinical) and major (i.e., clinical) «cases» of a disorder (e.g., depression; CDI, BDI), (f) lack of correspondence between items and DSM criteria (e.g., CBCL - 1991 version, CDI, BDI, CES - D, (g) a factor structure that lacks clarity across studies (e.g., PSPCSAYC, CASI; although the factor structure is often difficult to assess in studies of pediatric populations, given the small sample sizes), (h) low inter-rater reliability for interview and observational methods (e.g., CGAS), (i) low correlations between respondents such as child, parent, teacher [e.g., BASC, PSPCSAYC, CSI, FSSC - R, SCARED, Connors Ratings Scales - Revised (CRS - R)-RSB-, (j) the inclusion of somatic or physical symptom items on mental health subscales (e.g., CBCL), which is a problem when conducting studies of children with pediatric physical conditions because physical symptoms may be a feature of the condition rather than an indicator of a mental health problem, (k) high correlations with measures of social desirability, which is particularly problematic for the self - related rating scales and for child - report scales more generally, and (l) content validity problems (e.g., the RCMAS is a measure of anxiety, but contains items that tap mood, attention, peer interactions, and impulsivity).

However, many of these studies have considerable risk of bias, and if we only focused on trials with low risk of bias, there would no longer be enough studies to detect clinically relevant effects.

This scale was favoured given its focus on response tendencies, which makes it a more clinically relevant measure opposed to more pure cognitive or processing approaches to the study of emotions in BD.

Prior research has established the influence of maternal depression on the child's behavioral and emotional health3, 27,28 and its relevance for pediatric practice.29, 30 Several studies have analyzed the independent effects on children of mothers» and fathers» mental health, but few have examined the more clinically relevant question of how the mental health of parents jointly influences child outcomes.16, 31,32 The largest study of the joint effects of mothers» and fathers» mental health on children was a population - based study of twins and their parents.16 Similar to our results, the combination of maternal and paternal depression was associated with the largest increase in children's depressive symptoms.

The effects of peer - victimization on mental health problems were additionally related to normative SDQ data to obtain information about clinically relevant psychopathology in the investigated study sample.

Effects of peer - victimization on mental health problems were additionally compared with normative SDQ data in order to obtain information about clinically relevant psychopathology in our study sample.