Sentences with phrase «clock genes in mice»

«We anticipate a similar mode of action may operate in other organisms because similar RNAs have been found for clock genes in mice.

Not exact matches

These experiments revealed that the CLOCK protein targets the per gene in mice and both the per and tim genes in flies.

In 1997 Joseph Takaha - shi of the Howard Hughes Medical Institute at Northwestern University and his colleagues isolated a gene they called Clock that when mutated yielded mice with no discernible circadian rhythm.

An exciting prospect for the future involves the recovery of an entire system of clock - regulated genes in organisms such as fruit flies and mice.

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

They validated the cell models and showed that changing clock gene function in these cells is similar to what happens in mice lacking clock genes.

In today's issue of Cell, a team reports that it has found in mice and humans a close relative of a fruit fly clock gene — the first evidence that some of these genes may have been conserved over the course of evolutioIn today's issue of Cell, a team reports that it has found in mice and humans a close relative of a fruit fly clock gene — the first evidence that some of these genes may have been conserved over the course of evolutioin mice and humans a close relative of a fruit fly clock gene — the first evidence that some of these genes may have been conserved over the course of evolution.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

In recent years, clock researchers have uncovered some of the gears and springs that keep this circadian timepiece running, largely by identifying a handful of key genes in organisms from bread mold to micIn recent years, clock researchers have uncovered some of the gears and springs that keep this circadian timepiece running, largely by identifying a handful of key genes in organisms from bread mold to micin organisms from bread mold to mice.

The researchers in the RNA Biochemistry Group at Freie Universität Berlin were able to show that mice use this time - of - the - day - dependent change in body temperature to adapt gene expression to clock - dependent requirements.

Intrigued, Turek joined with endocrinologist Joseph Bass, also at Northwestern, to study the effects of regular and high - fat diets in normal mice and mice with a dysfunctional Clock gene.

The expression of core clock genes is altered in mice lacking the Chrono gene, and the mice have longer circadian cycles.

Associate Professor Amanda Sainsbury - Salis expressed surprise at the impact of the Y6 gene deletion on mice, commenting «I find it amazing that one gene, which is expressed in the small part of the brain that controls the body clock, has such a profound impact on how much fat is stored on the body, and how much lean tissue is maintained.»

The researchers also found that genes related to circadian rhythms (the body clock) were changed in mice exposed to e-cigarettes.

A study in mice has found that variations in a gene that regulates the circadian clock seem to increase the chances of breast cancer spreading.

In experiments with mice, disruptions in clock genes can lead to obesity, although scientists don't yet understand the mechanisIn experiments with mice, disruptions in clock genes can lead to obesity, although scientists don't yet understand the mechanisin clock genes can lead to obesity, although scientists don't yet understand the mechanism.

Mice lacking molecular - clock components (Per and Cry), or lacking Per genes in osteoblasts, display high bone mass, suggesting that bone remodeling may also be subject to circadian regulation.

In the initial report, mice harboring a mutation in the core circadian gene Clock (termed Clock mutant mice) were fed a high - fat (HF) diet and observed to develop obesity at a young age, as well as a variety of metabolic and endocrine abnormalities consistent with the metabolic syndrome (2In the initial report, mice harboring a mutation in the core circadian gene Clock (termed Clock mutant mice) were fed a high - fat (HF) diet and observed to develop obesity at a young age, as well as a variety of metabolic and endocrine abnormalities consistent with the metabolic syndrome (2in the core circadian gene Clock (termed Clock mutant mice) were fed a high - fat (HF) diet and observed to develop obesity at a young age, as well as a variety of metabolic and endocrine abnormalities consistent with the metabolic syndrome (2).