Reasons for resistance to transformation of mature lymphocytes are unclear, but may involve an unknown mechanism that ensures the diversity of the TCR repertoire and thus limits
clonal outgrowth [54].
In contrast, the safety record of hematopoietic stem cell gene therapy is less clear, with a significant frequency of gene - therapy induced oncogenesis or
clonal outgrowth reported in several hematopoietic stem cell trials [56], [57].
Not exact matches
In all 7 cases, the results suggest a linear model of
clonal evolution, in which progression from MDS to sAML was characterized by persistence of a single founder clone (defined by ~ 200 - 700 mutations) and the
outgrowth of at least one new subclone which contained dozens or hundreds of additional mutations.